caup (Drosophila melanogaster)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 FBgn0015919 T217473_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ morphogenesis; muscle cell fate commitment; and negative regulation of growth. Predicted to be active in nucleus. Is expressed in several structures, including germ layer; imaginal disc; presumptive embryonic/larval system; segment; and transverse muscle cell. Orthologous to several human genes including IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
caup
M06315_2.00		 Drosophila melanogaster
HWDWAACA
TGTTWHWD		 B1H
Zhu et al.(2011)
Caup_Cell_FBgn0015919		 (Direct) (Direct)
caup
M06316_2.00		 Drosophila melanogaster
NDDACA
TGTHHN		 B1H
Zhu et al.(2011)
Caup_SOLEXA_FBgn0015919		 (Direct) (Direct)
caup
M06519_2.00		 Drosophila melanogaster
WAACA
TGTTW		 B1H
Mathelier et al.(2014)
MA0217.1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ara
M06518_2.00 		Drosophila melanogaster
WWACA
TGTWW		 B1H
Mathelier et al.(2014)
MA0210.1 		0.858 0.947
ara
M06313_2.00 		Drosophila melanogaster
TGTWWWNN
NNWWWACA		 B1H
Zhu et al.(2011)
Ara_Cell_FBgn0015904 		0.858 0.947
ara
M06314_2.00 		Drosophila melanogaster
DWWACA
TGTWWH		 B1H
Zhu et al.(2011)
Ara_SOLEXA_FBgn0015904 		0.858 0.947
Irx6
M00456_2.00 		Mus musculus
NNDAHWN
NWDTHNN		 PBM
Berger et al.(2008)
Irx6_2623 		0.824 0.895
Irx2
M00386_2.00 		Mus musculus
NNDACAHNN
NNDTGTHNN		 PBM
Berger et al.(2008)
Irx2_0900 		0.806 0.877
Irx5
M00455_2.00 		Mus musculus
NNNDACAHN
NDTGTHNNN		 PBM
Berger et al.(2008)
Irx5_2385 		0.806 0.877
IRX2
M03212_2.00 		Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN		 SELEX
Jolma et al.(2013)
IRX2_1 		0.806 0.877
IRX5
M03222_2.00 		Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN		 SELEX
Jolma et al.(2013)
IRX5_1 		0.806 0.877
IRX5
M05315_2.00 		Homo sapiens
NBDTGTHNDACAYVN
NBRTGTHNDACAHVN		 SELEX
Yin et al.(2017)
IRX5_eDBD_HT-SELEX 		0.806 0.877
IRX5
M05316_2.00 		Homo sapiens
WYRYGHHNHAYRYRY
RYRYRTDNDDCRYRW		 SELEX
Yin et al.(2017)
IRX5_eDBD_Methyl-HT-SELEX 		0.806 0.877
Irx4
M00416_2.00 		Mus musculus
NNNDAMAH
DTKTHNNN		 PBM
Berger et al.(2008)
Irx4_2242 		0.780 0.877
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0075641 Homeodomain 227 286

Links

Other Homeodomain family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

387 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action