CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Optix
(
Drosophila melanogaster
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
FBgn0025360
T217491_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity. Involved in compound eye photoreceptor cell differentiation; dendrite morphogenesis; and progression of morphogenetic furrow involved in compound eye morphogenesis. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anterior ectoderm anlage; ectoderm; extended germ band embryo; head; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in holoprosencephaly; holoprosencephaly 2; and optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX3 (SIX homeobox 3) and SIX6 (SIX homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Optix
M02124_2.00
Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN
PBM
Weirauch et al.(2014)
pTH5437
(Direct)
(Direct)
Optix
M03850_2.00
Drosophila melanogaster
TAATYTAATTA
TAATTARATTA
SELEX
Nitta et al.(2015)
Optix_1
(Direct)
(Direct)
Optix
M06327_2.00
Drosophila melanogaster
HHVTGATA
TATCABDD
B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360
(Direct)
(Direct)
Optix
M06328_2.00
Drosophila melanogaster
NNNTGATA
TATCANNN
B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360
(Direct)
(Direct)
Optix
M06526_2.00
Drosophila melanogaster
TGATA
TATCA
B1H
Mathelier et al.(2014)
MA0199.1
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Six3
M00483_2.00
Mus musculus
NNNAYMN
NKRTNNN
PBM
Berger et al.(2008)
Six3_1732
0.867
0.947
SIX3
M05159_2.00
Homo sapiens
NNYGATABBN
NVVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX
0.867
0.947
SIX3
M10698_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIX3_Q6
0.867
0.947
SIX3
M05160_2.00
Homo sapiens
NNYGATABVB
VBVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX
0.867
0.947
SIX6
M00326_2.00
Homo sapiens
NNDATMB
VKATHNN
PBM
Barrera et al.(2016)
SIX6_REF
0.865
0.930
Six6
M00169_2.00
Mus musculus
NNAYMNN
NNKRTNN
PBM
Badis et al.(2009)
Six6_2267
0.865
0.930
Six6
M00412_2.00
Mus musculus
NNNTGATAYCN
NGRTATCANNN
PBM
Berger et al.(2008)
Six6_2267
0.865
0.930
six3
M02102_2.00
Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN
PBM
Weirauch et al.(2014)
pTH5928
0.865
0.930
SIX6
M05357_2.00
Homo sapiens
NNYGATASVB
VBSTATCRNN
SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX
0.865
0.930
SIX6
M00325_2.00
Homo sapiens
NNNDATMB
VKATHNNN
PBM
Barrera et al.(2016)
SIX6_H141N
0.865
0.930
SIX6
M05358_2.00
Homo sapiens
VBVYAYCRNN
NNYGRTRBVB
SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX
0.865
0.930
SIX6
M00327_2.00
Homo sapiens
NHDAYMBNN
NNVKRTHDN
PBM
Barrera et al.(2016)
SIX6_T165A
0.859
0.912
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M02124_2.00
Homeodomain
1
57
EQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRA
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0087941
Homeodomain
157
213
EQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRA
FBpp0302920
Homeodomain
157
213
EQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRA
Links
Other
Homeodomain
family TFs
Other
Drosophila melanogaster
TFs
297 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy