TF Information

ceh-34 *(Caenorhabditis elegans)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00046 (Homeobox)	IPR001356	WBGene00000455	T224619_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of apoptotic process involved in development; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in body wall musculature; head; male sex myoblast; and pharynx. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to several human genes including SIX2 (SIX homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
ceh-34 M00672_2.00	Caenorhabditis elegans	NNNRDAWNNN	NNNWTHYNNN	PBM Narasimhan et al.(2015) pTH9708	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
so M02117_2.00	Drosophila melanogaster	NDATMYNNN	NNNRKATHN	PBM Weirauch et al.(2014) pTH5690	0.664	0.625
so M03800_2.00	Drosophila melanogaster	NYGATAYB	VRTATCRN	SELEX Nitta et al.(2015) so_1	0.664	0.625
so M03801_2.00	Drosophila melanogaster	YKATAYNNNYGATAY	RTATCRNNNRTATMR	SELEX Nitta et al.(2015) so_2	0.664	0.625
so M03802_2.00	Drosophila melanogaster	YGATACGTATCR	YGATACGTATCR	SELEX Nitta et al.(2015) so_3	0.664	0.625
so M03803_2.00	Drosophila melanogaster	RTATCRYGATAC	GTATCRYGATAY	SELEX Nitta et al.(2015) so_4	0.664	0.625
so M06497_2.00	Drosophila melanogaster	TGATAC	GTATCA	B1H Mathelier et al.(2014) MA0246.1	0.664	0.625
so M06268_2.00	Drosophila melanogaster	NRTGATA	TATCAYN	B1H Zhu et al.(2011) So_Cell_FBgn0003460	0.664	0.625
so M06269_2.00	Drosophila melanogaster	NNNTGATA	TATCANNN	B1H Zhu et al.(2011) So_SOLEXA_FBgn0003460	0.664	0.625
Six2 M00425_2.00	Mus musculus	NNAYMYNN	NNRKRTNN	PBM Berger et al.(2008) Six2_2307	0.664	0.607
Six1 M00512_2.00	Mus musculus	NNDATMYNNN	NNNRKATHNN	PBM Berger et al.(2008) Six1_0935	0.664	0.607
SIX1 M05094_2.00	Homo sapiens	NNYGATACVB	VBGTATCRNN	SELEX Yin et al.(2017) SIX1_eDBD_HT-SELEX	0.664	0.607
SIX1 M05096_2.00	Homo sapiens	NNYGATAYVB	VBRTATCRNN	SELEX Yin et al.(2017) SIX1_FL_HT-SELEX	0.664	0.607
SIX2 M05285_2.00	Homo sapiens	NNYGATACSB	VSGTATCRNN	SELEX Yin et al.(2017) SIX2_eDBD_HT-SELEX	0.664	0.607
SIX2 M05287_2.00	Homo sapiens	NSGTRWCRYN	NRYGWYACSN	SELEX Yin et al.(2017) SIX2_FL_HT-SELEX	0.664	0.607
SIX1 M08130_2.00	Homo sapiens	GWAACCTGANM	KNTCAGGTTWC	ChIP-seq Mathelier et al.(2014) MA1118.1	0.664	0.607
SIX2 M08133_2.00	Homo sapiens	NNNTGWAACCTGAKMH	DKMTCAGGTTWCANNN	ChIP-seq Mathelier et al.(2014) MA1119.1	0.664	0.607
SIX1 M09142_2.00	Homo sapiens	DGWAAYHTGABMYN	NRKVTCADRTTWCH	Misc Kulakovskiy et al.(2013) SIX1_HUMAN.H11MO.0.A	0.664	0.607
SIX2 M09157_2.00	Homo sapiens	DGWAAYHHGABMH	DKVTCDDRTTWCH	Misc Kulakovskiy et al.(2013) SIX2_HUMAN.H11MO.0.A	0.664	0.607
Six2 M09185_2.00	Mus musculus	DGWAAYHYRABMYB	VRKVTYRDRTTWCH	Misc Kulakovskiy et al.(2013) SIX2_MOUSE.H11MO.0.A	0.664	0.607
Six1 M09579_2.00	Mus musculus	GWAAYHTGABMH	DKVTCADRTTWC	Misc Heinz et al.(2010) Myoblast-Six1_GSE20150	0.664	0.607
SIX1 M10684_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SIX1_Q3_01	0.664	0.607
SIX1 M10685_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SIX1_Q3	0.664	0.607
SIX1 M05095_2.00	Homo sapiens	NNYGATABNB	VNVTATCRNN	SELEX Yin et al.(2017) SIX1_eDBD_Methyl-HT-SELEX	0.664	0.607
SIX1 M05097_2.00	Homo sapiens	NNYGATAYSB	VSRTATCRNN	SELEX Yin et al.(2017) SIX1_FL_Methyl-HT-SELEX	0.664	0.607
SIX2 M05286_2.00	Homo sapiens	NBRTATCRNN	NNYGATAYVN	SELEX Yin et al.(2017) SIX2_eDBD_Methyl-HT-SELEX	0.664	0.607
SIX2 M05288_2.00	Homo sapiens	VBRTAWCRNN	NNYGWTAYVB	SELEX Yin et al.(2017) SIX2_FL_Methyl-HT-SELEX	0.664	0.607
Six4 M00461_2.00	Mus musculus	NNKABMHNN	NNDKVTMNN	PBM Berger et al.(2008) Six4_2860	0.634	0.571
SIX4 M04939_2.00	Homo sapiens	NVYGATACVB	VBGTATCRBN	SELEX Yin et al.(2017) SIX4_eDBD_HT-SELEX	0.634	0.571
Six4 M09198_2.00	Mus musculus	DGDAABHNSASNNN	NNNSTSNDVTTHCH	Misc Kulakovskiy et al.(2013) SIX4_MOUSE.H11MO.0.C	0.634	0.571
SIX4 M10646_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SIX4_Q3	0.634	0.571
SIX4 M04940_2.00	Homo sapiens	NBGTAWCRHN	NDYGWTACVN	SELEX Yin et al.(2017) SIX4_eDBD_Methyl-HT-SELEX	0.634	0.571
SIX5 M08208_2.00	Homo sapiens	GARWTGTAGT	ACTACAWYTC	ChIP-seq Contrino et al.(2012) Mv121	0.633	0.536
SIX5 M08209_2.00	Homo sapiens	GGAGTTGT	ACAACTCC	ChIP-seq Contrino et al.(2012) Mv123	0.633	0.536
SIX5 M10738_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SIX5_01	0.633	0.536
SIX5 M10739_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SIX5_02	0.633	0.536
Six4 M00563_2.00	Drosophila melanogaster	NNDANMHNN	NNDKNTHNN	PBM Busser et al.(2012a) Six4	0.633	0.518
Six4 M06530_2.00	Drosophila melanogaster	TGABAC	GTVTCA	B1H Mathelier et al.(2014) MA0204.1	0.633	0.518
Six4 M06334_2.00	Drosophila melanogaster	WDDTGABAC	GTVTCAHHW	B1H Zhu et al.(2011) Six4_Cell_FBgn0027364	0.633	0.518
Six4 M06335_2.00	Drosophila melanogaster	NTGAKACB	VGTMTCAN	B1H Zhu et al.(2011) Six4_SOLEXA_2_FBgn0027364	0.633	0.518
Six4 M06336_2.00	Drosophila melanogaster	NNNTGABA	TVTCANNN	B1H Zhu et al.(2011) Six4_SOLEXA_FBgn0027364	0.633	0.518
For this family, TFs with SR scores > 0.599* will likely have a similar motif*