TF Information

ENSP00000226382 *(Macaca fascicularis)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00046 (Homeobox)	IPR001356	ENSP00000226382	T225965_2.00	GigaDB (2015-Oct-22)
NCBI Gene Info: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
VSX1 M03087_2.00	Homo sapiens	YTAATTAN	NTAATTAR	SELEX Jolma et al.(2013) VSX1_1	0.804	0.587
VSX1 M03088_2.00	Homo sapiens	NNYAATTRRBN	NVYYAATTRNN	SELEX Jolma et al.(2013) VSX1_2	0.804	0.587
VSX1 M04941_2.00	Homo sapiens	YYAATTRN	NYAATTRR	SELEX Yin et al.(2017) VSX1_eDBD_HT-SELEX	0.804	0.587
VSX1 M04944_2.00	Homo sapiens	NTAATTRS	SYAATTAN	SELEX Yin et al.(2017) VSX1_FL_HT-SELEX	0.804	0.587
VSX1 M05869_2.00	Homo sapiens	DGCTAATTAN	NTAATTAGCH	SMiLE-seq Isakova et al.(2017) VSX1	0.804	0.587
VSX1 M04942_2.00	Homo sapiens	NTAAYGMN	NKCRTTAN	SELEX Yin et al.(2017) VSX1_eDBD_Methyl-HT-SELEX_1	0.804	0.587
VSX1 M04943_2.00	Homo sapiens	YYAATTRN	NYAATTRR	SELEX Yin et al.(2017) VSX1_eDBD_Methyl-HT-SELEX_2	0.804	0.587
VSX1 M04945_2.00	Homo sapiens	NTAATTRG	CYAATTAN	SELEX Yin et al.(2017) VSX1_FL_Methyl-HT-SELEX_1	0.804	0.587
VSX1 M04946_2.00	Homo sapiens	NTAAYGAN	NTCRTTAN	SELEX Yin et al.(2017) VSX1_FL_Methyl-HT-SELEX_2	0.804	0.587
VAX1 M03168_2.00	Homo sapiens	YTAATKAN	NTMATTAR	SELEX Jolma et al.(2013) VAX1_1	0.718	0.370
VAX1 M05182_2.00	Homo sapiens	BTAATTRN	NYAATTAV	SELEX Yin et al.(2017) VAX1_eDBD_HT-SELEX	0.718	0.370
VAX1 M05183_2.00	Homo sapiens	BTMATKRN	NYMATKAV	SELEX Yin et al.(2017) VAX1_eDBD_Methyl-HT-SELEX	0.718	0.370
For this family, TFs with SR scores > 0.599* will likely have a similar motif*