HHAL002166-PA (Halyomorpha halys)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox) IPR001356 HHAL002166-PA T229828_2.00 Misc (2018-Jan-19)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Hlx
M00485_2.00
Mus musculus
NNNAWND

HNWTNNN
PBM
Berger et al.(2008)
Hlx1_2350
0.845 0.895
H2.0
M06489_2.00
Drosophila melanogaster
WTWATDA

THATWAW
B1H
Mathelier et al.(2014)
MA0448.1
0.845 0.877
H2.0
M06250_2.00
Drosophila melanogaster
TWWWWDA

THAWWWA
B1H
Zhu et al.(2011)
H2.0_Cell_FBgn0001170
0.845 0.877
H2.0
M06251_2.00
Drosophila melanogaster
WTWATTRN

NYAATWAW
B1H
Zhu et al.(2011)
H2.0_SOLEXA_FBgn0001170
0.845 0.877
Dbx
M02128_2.00
Drosophila melanogaster
WTTAATTA

TAATTAAW
PBM
Weirauch et al.(2014)
pTH6051
0.734 0.737
Dbx
M06550_2.00
Drosophila melanogaster
TTWATKA

TMATWAA
B1H
Mathelier et al.(2014)
MA0174.1
0.734 0.737
Dbx1
M00451_2.00
Mus musculus
WTTAATTA

TAATTAAW
PBM
Berger et al.(2008)
Dbx1_3486
0.734 0.702
Dbx2
M00499_2.00
Mus musculus
NNDTNNN

NNNAHNN
PBM
Berger et al.(2008)
Dbx2_3487
0.714 0.684
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
HHAL002166-PA Homeodomain 72 128

Links

Other Homeodomain family TFs
Other Halyomorpha halys TFs

264 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Hsal_11910--XP_001121170.1_APIME Harpegnathos saltator Hsal_11910--XP_001121170.1_APIME I 0.866
Cflo_10458--XP_001121170.1_APIME Camponotus floridanus Cflo_10458--XP_001121170.1_APIME I 0.866
ACEP14997 Atta cephalotes ACEP14997 I 0.866
SINV11867 Solenopsis invicta SINV11867 I 0.866
GB42897 Apis mellifera GB42897 I 0.866
TC008368 Tribolium castaneum TC008368 I 0.863
L798_13412 Zootermopsis nevadensis L798_13412 I 0.863
PHUM604510 Pediculus humanus PHUM604510 I 0.863
AFUN003184 Anopheles funestus AFUN003184 I 0.862
KGM_21891 Danaus plexippus KGM_21891 I 0.858
SMAR002236 Strigamia maritima SMAR002236 I 0.858
RPRC010617 Rhodnius prolixus RPRC010617 I 0.858
BGIBMGA008482 Bombyx mori BGIBMGA008482 I 0.858
CLEC011407 Cimex lectularius CLEC011407 I 0.858
ADIR004110 Anopheles dirus ADIR004110 I 0.850
SPU_014802 Strongylocentrotus purpuratus SPU_014802 I 0.849
ASIS013776 Anopheles sinensis ASIS013776 I 0.846
HLX Otolemur garnettii ENSOGAG00000012065 I 0.845
HLX Procavia capensis ENSPCAG00000012295 I 0.845
ENSPANG00000010481 Papio anubis ENSPANG00000010481 I 0.845
ENSONIG00000005980 Oreochromis niloticus ENSONIG00000005980 I 0.845
hlx1 Oryzias latipes ENSORLG00000012055 I 0.845
ENSPFOG00000018919 Poecilia formosa ENSPFOG00000018919 I 0.845
Hlx Rattus norvegicus ENSRNOG00000002309 I 0.845
ENSSHAG00000012054 Sarcophilus harrisii ENSSHAG00000012054 I 0.845
HLX Pteropus vampyrus ENSPVAG00000004552 I 0.845
HLX Pan troglodytes ENSPTRG00000002004 I 0.845
ENSPSIG00000013519 Pelodiscus sinensis ENSPSIG00000013519 I 0.845
HLX Oryctolagus cuniculus ENSOCUG00000006015 I 0.845
Hlx Mus musculus ENSMUSG00000039377 D 0.845
HLX Loxodonta africana ENSLAFG00000001289 I 0.845
ENSLOCG00000016392 Lepisosteus oculatus ENSLOCG00000016392 I 0.845
HLX Monodelphis domestica ENSMODG00000004664 I 0.845
ENSMICG00000005919 Microcebus murinus ENSMICG00000005919 I 0.845
ENSLACG00000008955 Latimeria chalumnae ENSLACG00000008955 I 0.845
ENSSSCG00000010830 Sus scrofa ENSSSCG00000010830 I 0.845
ENSNLEG00000013773 Nomascus leucogenys ENSNLEG00000013773 I 0.845
HLX Myotis lucifugus ENSMLUG00000015571 I 0.845
ENSMPUG00000003954 Mustela putorius furo ENSMPUG00000003954 I 0.845
ENSGMOG00000001751 Gadus morhua ENSGMOG00000001751 I 0.845
ENSOARG00000013206 Ovis aries ENSOARG00000013206 I 0.845
GH10711 Drosophila grimshawi FBgn0118192 I 0.845
GE18959 Drosophila yakuba FBgn0236329 I 0.845
ENSBTAP00000019352-D1 Bos grunniens ENSBTAP00000019352-D1 I 0.845
GK15402 Drosophila willistoni FBgn0217407 I 0.845
GJ12503 Drosophila virilis FBgn0199743 I 0.845
GD22610 Drosophila simulans FBgn0194011 I 0.845
Ogr19305 Ophisaurus gracilis Ogr19305 I 0.845
Pvit_13000 Pogona vitticeps Pvit_13000 I 0.845
MDOA007091 Musca domestica MDOA007091 I 0.845
hlx Xenopus tropicalis XB-GENE-483226 I 0.845
LCUP007749 Lucilia cuprina LCUP007749 I 0.845
Sakowv30040055m.g Saccoglossus kowalevskii Sakowv30040055m.g I 0.845
GM17974 Drosophila sechellia FBgn0172881 I 0.845
GL19089 Drosophila persimilis FBgn0156689 I 0.845
ENSXMAG00000017389 Xiphophorus maculatus ENSXMAG00000017389 I 0.845
hlx1 Takifugu rubripes ENSTRUG00000006753 I 0.845
hlx1 Tetraodon nigroviridis ENSTNIG00000016400 I 0.845
HLX Tupaia belangeri ENSTBEG00000014384 I 0.845
H2.0 Drosophila melanogaster FBgn0001170 D 0.845
GA11095 Drosophila pseudoobscura FBgn0071150 I 0.845
GI11292 Drosophila mojavensis FBgn0134053 I 0.845
HLX Gorilla gorilla ENSGGOG00000002735 I 0.845
GG10151 Drosophila erecta FBgn0102462 I 0.845
GF14286 Drosophila ananassae FBgn0091313 I 0.845
ENSSTOG00000006326 Ictidomys tridecemlineatus ENSSTOG00000006326 I 0.845
ENSPPYG00000000202 Pongo abelii ENSPPYG00000000202 I 0.845
HLX Equus caballus ENSECAG00000003025 I 0.845
Hlx Dipodomys ordii ENSDORG00000001941 I 0.845
ENSAMEG00000010272 Ailuropoda melanoleuca ENSAMEG00000010272 I 0.845
HLX Canis familiaris ENSCAFG00000011340 I 0.845
HLX Bos taurus ENSBTAG00000014560 I 0.845
HLX Homo sapiens ENSG00000136630 I 0.845
HLX Erinaceus europaeus ENSEEUG00000004973 I 0.845
HLX Callithrix jacchus ENSCJAG00000006110 I 0.845
ENSAMXG00000013419 Astyanax mexicanus ENSAMXG00000013419 I 0.845
HLX Cavia porcellus ENSCPOG00000024028 I 0.845
hlx1 Danio rerio ENSDARG00000009134 I 0.845
ENSCSAG00000015879 Chlorocebus sabaeus ENSCSAG00000015879 I 0.845
HLX Dasypus novemcinctus ENSDNOG00000007014 I 0.845
CGI_10013972 Crassostrea gigas CGI_10013972 I 0.845
hlx1 Gasterosteus aculeatus ENSGACG00000010057 I 0.845
ENSPMAG00000009840 Petromyzon marinus ENSPMAG00000009840 I 0.818
CapteG173964 Capitella teleta CapteG173964 I 0.814
ENSOANG00000001435 Ornithorhynchus anatinus ENSOANG00000001435 I 0.807
LotgiG80492 Lottia gigantea LotgiG80492 I 0.792
gw.83.80.1 Branchiostoma floridae gw.83.80.1 I 0.792
gw.473.22.1 Branchiostoma floridae gw.473.22.1 I 0.792
HLX Ochotona princeps ENSOPRG00000011504 I 0.789
HLX Felis catus ENSFCAG00000002974 I 0.780
DAPPUDRAFT_53297 Daphnia pulex DAPPUDRAFT_53297 I 0.777
hlx Ciona intestinalis ENSCING00000019191 I 0.773
HelroG148518 Helobdella robusta HelroG148518 I 0.773
AAEL012150 Aedes aegypti AAEL012150 I 0.770
NEMVEDRAFT_v1g100892 Nematostella vectensis NEMVEDRAFT_v1g100892 I 0.752
NEMVEDRAFT_v1g80365 Nematostella vectensis NEMVEDRAFT_v1g80365 I 0.752
LDEC019190 Leptinotarsa decemlineata LDEC019190 I 0.750
KGM_12383 Danaus plexippus KGM_12383 I 0.739
ACOM031223 Anopheles coluzzii ACOM031223 I 0.739
AMEM006151 Anopheles merus AMEM006151 I 0.739
AGAP005727 Anopheles gambiae AGAP005727 I 0.739
AATE018929 Anopheles atroparvus AATE018929 I 0.739
AAEL005974 Aedes aegypti AAEL005974 I 0.739
ENSCING00000012835 Ciona intestinalis ENSCING00000012835 I 0.739
NV18099 Nasonia vitripennis NV18099 I 0.737
DBX1 Callithrix jacchus ENSCJAG00000006734 I 0.734
GA11582 Drosophila pseudoobscura FBgn0071633 I 0.734
fgenesh2_pg.scaffold_222000058 Branchiostoma floridae fgenesh2_pg.scaffold_222000058 I 0.734
Tal_R010631 Tyto alba Tal_R010631 I 0.734
GG14836 Drosophila erecta FBgn0107091 I 0.734
DBX1 Cavia porcellus ENSCPOG00000019811 I 0.734
Pvit_06412 Pogona vitticeps Pvit_06412 I 0.734
GF20095 Drosophila ananassae FBgn0097102 I 0.734
dbx1b Takifugu rubripes ENSTRUG00000015886 I 0.734
DBX1 Taeniopygia guttata ENSTGUG00000015791 I 0.734
CGI_10002480 Crassostrea gigas CGI_10002480 I 0.734
CapteG220261 Capitella teleta CapteG220261 I 0.734
ENSSTOG00000015557 Ictidomys tridecemlineatus ENSSTOG00000015557 I 0.734
ENSCSAG00000005115 Chlorocebus sabaeus ENSCSAG00000005115 I 0.734
Sakowv30044972m.g Saccoglossus kowalevskii Sakowv30044972m.g I 0.734
Ocbimv22005553m.g Octopus bimaculoides Ocbimv22005553m.g I 0.734
ENSXMAG00000006476 Xiphophorus maculatus ENSXMAG00000006476 I 0.734
GH16166 Drosophila grimshawi FBgn0123637 I 0.734
ENSXMAG00000010186 Xiphophorus maculatus ENSXMAG00000010186 I 0.734
GI13319 Drosophila mojavensis FBgn0136076 I 0.734
ENSAMXG00000016737 Astyanax mexicanus ENSAMXG00000016737 I 0.734
dbx1.S Xenopus laevis XB-GENE-865351 I 0.734
dbx1b Danio rerio ENSDARG00000001859 I 0.734
Dbx Drosophila melanogaster FBgn0261723 D 0.734
Afo_R010414 Aptenodytes forsteri Afo_R010414 I 0.734
LotgiG64310 Lottia gigantea LotgiG64310 I 0.734
Aan_R006646 Calypte anna Aan_R006646 I 0.734
DBX1 Anolis carolinensis ENSACAG00000015625 I 0.734
PHUM365830 Pediculus humanus PHUM365830 I 0.734
TC015146 Tribolium castaneum TC015146 I 0.734
YQE_05944 Dendroctonus ponderosae YQE_05944 I 0.734
GE21201 Drosophila yakuba FBgn0238476 I 0.734
ENSAPLG00000013752 Anas platyrhynchos ENSAPLG00000013752 I 0.734
GL25317 Drosophila persimilis FBgn0162901 I 0.734
Cmyd_10016425 Chelonia mydas Cmyd_10016425 I 0.734
ENSAMXG00000012905 Astyanax mexicanus ENSAMXG00000012905 I 0.734
ENSBTAP00000003543-D1 Bos grunniens ENSBTAP00000003543-D1 I 0.734
GM14459 Drosophila sechellia FBgn0169382 I 0.734
Brh_R002799 Buceros rhinoceros Brh_R002799 I 0.734
DBX1 Bos taurus ENSBTAG00000002733 I 0.734
GK12528 Drosophila willistoni FBgn0214538 I 0.734
GJ12089 Drosophila virilis FBgn0199341 I 0.734
Alligator_sinensis_CCG013033.1 Alligator sinensis Alligator_sinensis_CCG013033.1 I 0.734
dbx1 Xenopus tropicalis XB-GENE-480177 I 0.734
dbx1b Tetraodon nigroviridis ENSTNIG00000009613 I 0.734
BGLB013811 Biomphalaria glabrata BGLB013811 I 0.734
dbx1b Oryzias latipes ENSORLG00000000807 I 0.734
LLOJ006552 Lutzomyia longipalpis LLOJ006552 I 0.734
DBX1 Oryzias latipes ENSORLG00000014512 I 0.734
ENSGACG00000000220 Gasterosteus aculeatus ENSGACG00000000220 I 0.734
ENSLOCG00000004886 Lepisosteus oculatus ENSLOCG00000004886 I 0.734
ENSPMAG00000004878 Petromyzon marinus ENSPMAG00000004878 I 0.734
ENSPFOG00000004028 Poecilia formosa ENSPFOG00000004028 I 0.734
ENSONIG00000007144 Oreochromis niloticus ENSONIG00000007144 I 0.734
DBX1 Equus caballus ENSECAG00000019994 I 0.734
ENSFALG00000001676 Ficedula albicollis ENSFALG00000001676 I 0.734
ENSOARG00000008379 Ovis aries ENSOARG00000008379 I 0.734
Dbx1 Mus musculus ENSMUSG00000030507 D 0.734
ENSMGAG00000002299 Meleagris gallopavo ENSMGAG00000002299 I 0.734
DBX1 Oryctolagus cuniculus ENSOCUG00000007615 I 0.734
DBX1 Otolemur garnettii ENSOGAG00000014591 I 0.734
DBX1 Felis catus ENSFCAG00000028654 I 0.734
ENSMPUG00000013914 Mustela putorius furo ENSMPUG00000013914 I 0.734
DBX1 Loxodonta africana ENSLAFG00000007378 I 0.734
ENSPFOG00000014727 Poecilia formosa ENSPFOG00000014727 I 0.734
MDOA015219 Musca domestica MDOA015219 I 0.734
dbx1a Danio rerio ENSDARG00000086393 I 0.734
ENSLACG00000011299 Latimeria chalumnae ENSLACG00000011299 I 0.734
ENSSHAG00000011774 Sarcophilus harrisii ENSSHAG00000011774 I 0.734
Dbx1 Rattus norvegicus ENSRNOG00000014706 I 0.734
ENSGMOG00000003244 Gadus morhua ENSGMOG00000003244 I 0.734
DBX1 Homo sapiens ENSG00000109851 I 0.734
DBX1 Gasterosteus aculeatus ENSGACG00000014112 I 0.734
ENSPSIG00000012138 Pelodiscus sinensis ENSPSIG00000012138 I 0.734
DBX1 Monodelphis domestica ENSMODG00000009081 I 0.734
DBX1 Gallus gallus ENSGALG00000003965 I 0.734
DBX1 Dasypus novemcinctus ENSDNOG00000015450 I 0.734
DBX1 Sus scrofa ENSSSCG00000013350 I 0.734
DAPPUDRAFT_37379 Daphnia pulex DAPPUDRAFT_37379 I 0.733
ISCW020093 Ixodes scapularis ISCW020093 I 0.733
DBX1 Tetraodon nigroviridis ENSTNIG00000004855 I 0.733
tetur05g09190 Tetranychus urticae tetur05g09190 I 0.733
GB49362 Apis mellifera GB49362 I 0.733
ENSONIG00000012709 Oreochromis niloticus ENSONIG00000012709 I 0.732
ACYPI27939 Acyrthosiphon pisum ACYPI27939 I 0.732
TriadG18102 Trichoplax adhaerens TriadG18102 I 0.732
nRc.2.0.1.g17174 Romanomermis culicivorax nRc.2.0.1.g17174 I 0.729
ACYPI48371 Acyrthosiphon pisum ACYPI48371 I 0.728
DBX2 Dasypus novemcinctus ENSDNOG00000046429 I 0.726
DBX2 Tursiops truncatus ENSTTRG00000003582 I 0.726
ENSOCUG00000022068 Oryctolagus cuniculus ENSOCUG00000022068 I 0.726
ENSLACG00000003968 Latimeria chalumnae ENSLACG00000003968 I 0.723
Aan_R012348 Calypte anna Aan_R012348 I 0.714
Afo_R000355 Aptenodytes forsteri Afo_R000355 I 0.714
ENSMLUG00000007038 Myotis lucifugus ENSMLUG00000007038 I 0.714
ENSMICG00000007764 Microcebus murinus ENSMICG00000007764 I 0.714
Gfo_R004056 Geospiza fortis Gfo_R004056 I 0.714
Myotis_brandtii_DBX2_10029487 Myotis brandtii Myotis_brandtii_DBX2_10029487 I 0.714
Tal_R005491 Tyto alba Tal_R005491 I 0.714
DBX2 Loxodonta africana ENSLAFG00000005006 I 0.714
DBX2 Gorilla gorilla ENSGGOG00000004664 I 0.714
ENSMMUG00000022290 Macaca mulatta ENSMMUG00000022290 I 0.714
ENSP00000331470 Macaca fascicularis ENSP00000331470 I 0.714
ENSMGAG00000009614 Meleagris gallopavo ENSMGAG00000009614 I 0.714
Brh_R003637 Buceros rhinoceros Brh_R003637 I 0.714
ENSACAG00000002581 Anolis carolinensis ENSACAG00000002581 I 0.714
ENSP00000331470-D1 Bos grunniens ENSP00000331470-D1 I 0.714
DBX2 Homo sapiens ENSG00000185610 I 0.714
ENSOARG00000019598 Ovis aries ENSOARG00000019598 I 0.714
ENSCPOG00000011069 Cavia porcellus ENSCPOG00000011069 I 0.714
DBX2 Pan troglodytes ENSPTRG00000004849 I 0.714
DBX2 Callithrix jacchus ENSCJAG00000013213 I 0.714
ENSPPYG00000004431 Pongo abelii ENSPPYG00000004431 I 0.714
ENSPANG00000005953 Papio anubis ENSPANG00000005953 I 0.714
DBX2 Procavia capensis ENSPCAG00000006299 I 0.714
DBX2 Gallus gallus ENSGALG00000009604 I 0.714
ENSVPAG00000000460 Vicugna pacos ENSVPAG00000000460 I 0.714
DBX2 Taeniopygia guttata ENSTGUG00000006020 I 0.714
DBX2 Tupaia belangeri ENSTBEG00000012639 I 0.714
ENSSARG00000007797 Sorex araneus ENSSARG00000007797 I 0.714
Dbx2 Rattus norvegicus ENSRNOG00000006885 I 0.714
ENSTSYG00000001451 Tarsius syrichta ENSTSYG00000001451 I 0.714
ENSCAFG00000009372 Canis familiaris ENSCAFG00000009372 I 0.714
DBX2 Equus caballus ENSECAG00000012695 I 0.714
ENSFALG00000010170 Ficedula albicollis ENSFALG00000010170 I 0.714
ENSNLEG00000017924 Nomascus leucogenys ENSNLEG00000017924 I 0.714
Dbx2 Mus musculus ENSMUSG00000045608 D 0.714
ENSMPUG00000000372 Mustela putorius furo ENSMPUG00000000372 I 0.714
ENSAMEG00000015811 Ailuropoda melanoleuca ENSAMEG00000015811 I 0.714
ENSSTOG00000000232 Ictidomys tridecemlineatus ENSSTOG00000000232 I 0.714
ENSAPLG00000011161 Anas platyrhynchos ENSAPLG00000011161 I 0.714
DBX2 Otolemur garnettii ENSOGAG00000008999 I 0.714
DBX2 Bos taurus ENSBTAG00000006635 I 0.714
ENSLOCG00000016431 Lepisosteus oculatus ENSLOCG00000016431 I 0.713
dbx2.L Xenopus laevis XB-GENE-6486281 I 0.712
ENSSHAG00000012659 Sarcophilus harrisii ENSSHAG00000012659 I 0.712
ENSPSIG00000009557 Pelodiscus sinensis ENSPSIG00000009557 I 0.712
DBX2 Monodelphis domestica ENSMODG00000018530 I 0.712
ENSMEUG00000016510 Macropus eugenii ENSMEUG00000016510 I 0.712
Pvit_11516 Pogona vitticeps Pvit_11516 I 0.712
dbx2 Xenopus tropicalis XB-GENE-481734 I 0.712
ENSXMAG00000004689 Xiphophorus maculatus ENSXMAG00000004689 I 0.711
ENSTRUG00000016696 Takifugu rubripes ENSTRUG00000016696 I 0.711
ENSTNIG00000015979 Tetraodon nigroviridis ENSTNIG00000015979 I 0.711
ENSORLG00000002970 Oryzias latipes ENSORLG00000002970 I 0.711
ENSAMXG00000014548 Astyanax mexicanus ENSAMXG00000014548 I 0.711
ENSONIG00000008764 Oreochromis niloticus ENSONIG00000008764 I 0.711
ENSGMOG00000009056 Gadus morhua ENSGMOG00000009056 I 0.711
ENSGACG00000004000 Gasterosteus aculeatus ENSGACG00000004000 I 0.711
ENSPFOG00000008292 Poecilia formosa ENSPFOG00000008292 I 0.711
CABZ01093502.1 Danio rerio ENSDARG00000105053 I 0.710
ENSEEUG00000006518 Erinaceus europaeus ENSEEUG00000006518 I 0.698
tetur22g00030 Tetranychus urticae tetur22g00030 I 0.666
ENSAMXG00000009415 Astyanax mexicanus ENSAMXG00000009415 I 0.649
D917_00900 Trichinella nativa D917_00900 I 0.618
EFV57815 Trichinella spiralis EFV57815 I 0.618
ENSPFOG00000009708 Poecilia formosa ENSPFOG00000009708 I 0.609
nanog Danio rerio ENSDARG00000075113 I 0.609
ENSACAG00000015317 Anolis carolinensis ENSACAG00000015317 I 0.608