TF Information

HHAL002166-PA *(Halyomorpha halys)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00046 (Homeobox)	IPR001356	HHAL002166-PA	T229828_2.00	Misc (2018-Jan-19)
NCBI Gene Info: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hlx M00485_2.00	Mus musculus	NNNAWND	HNWTNNN	PBM Berger et al.(2008) Hlx1_2350	0.845	0.895
H2.0 M06489_2.00	Drosophila melanogaster	WTWATDA	THATWAW	B1H Mathelier et al.(2014) MA0448.1	0.845	0.877
H2.0 M06250_2.00	Drosophila melanogaster	TWWWWDA	THAWWWA	B1H Zhu et al.(2011) H2.0_Cell_FBgn0001170	0.845	0.877
H2.0 M06251_2.00	Drosophila melanogaster	WTWATTRN	NYAATWAW	B1H Zhu et al.(2011) H2.0_SOLEXA_FBgn0001170	0.845	0.877
Dbx M02128_2.00	Drosophila melanogaster	WTTAATTA	TAATTAAW	PBM Weirauch et al.(2014) pTH6051	0.734	0.737
Dbx M06550_2.00	Drosophila melanogaster	TTWATKA	TMATWAA	B1H Mathelier et al.(2014) MA0174.1	0.734	0.737
Dbx1 M00451_2.00	Mus musculus	WTTAATTA	TAATTAAW	PBM Berger et al.(2008) Dbx1_3486	0.734	0.702
Dbx2 M00499_2.00	Mus musculus	NNDTNNN	NNNAHNN	PBM Berger et al.(2008) Dbx2_3487	0.714	0.684
For this family, TFs with SR scores > 0.599* will likely have a similar motif*