|
HHAL006656-PA
(Halyomorpha halys)
Homeodomain
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF00046 (Homeobox) |
IPR001356 |
HHAL006656-PA |
T229850_2.00 |
Misc (2018-Jan-19) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
Six4
M00563_2.00 |
Drosophila melanogaster |
NNDANMHNN |
NNDKNTHNN |
PBM
Busser et al.(2012a)
Six4
|
0.755
|
0.833
|
Six4
M06530_2.00 |
Drosophila melanogaster |
TGABAC |
GTVTCA |
B1H
Mathelier et al.(2014)
MA0204.1
|
0.755
|
0.833
|
Six4
M06334_2.00 |
Drosophila melanogaster |
WDDTGABAC |
GTVTCAHHW |
B1H
Zhu et al.(2011)
Six4_Cell_FBgn0027364
|
0.755
|
0.833
|
Six4
M06335_2.00 |
Drosophila melanogaster |
NTGAKACB |
VGTMTCAN |
B1H
Zhu et al.(2011)
Six4_SOLEXA_2_FBgn0027364
|
0.755
|
0.833
|
Six4
M06336_2.00 |
Drosophila melanogaster |
NNNTGABA |
TVTCANNN |
B1H
Zhu et al.(2011)
Six4_SOLEXA_FBgn0027364
|
0.755
|
0.833
|
Six4
M00461_2.00 |
Mus musculus |
NNKABMHNN |
NNDKVTMNN |
PBM
Berger et al.(2008)
Six4_2860
|
0.743
|
0.796
|
SIX4
M04939_2.00 |
Homo sapiens |
NVYGATACVB |
VBGTATCRBN |
SELEX
Yin et al.(2017)
SIX4_eDBD_HT-SELEX
|
0.743
|
0.796
|
Six4
M09198_2.00 |
Mus musculus |
DGDAABHNSASNNN |
NNNSTSNDVTTHCH |
Misc
Kulakovskiy et al.(2013)
SIX4_MOUSE.H11MO.0.C
|
0.743
|
0.796
|
SIX4
M10646_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SIX4_Q3
|
0.743
|
0.796
|
SIX4
M04940_2.00 |
Homo sapiens |
NBGTAWCRHN |
NDYGWTACVN |
SELEX
Yin et al.(2017)
SIX4_eDBD_Methyl-HT-SELEX
|
0.743
|
0.796
|
SIX5
M08208_2.00 |
Homo sapiens |
GARWTGTAGT |
ACTACAWYTC |
ChIP-seq
Contrino et al.(2012)
Mv121
|
0.741
|
0.759
|
SIX5
M08209_2.00 |
Homo sapiens |
GGAGTTGT |
ACAACTCC |
ChIP-seq
Contrino et al.(2012)
Mv123
|
0.741
|
0.759
|
SIX5
M10738_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SIX5_01
|
0.741
|
0.759
|
SIX5
M10739_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SIX5_02
|
0.741
|
0.759
|
Six2
M00425_2.00 |
Mus musculus |
NNAYMYNN |
NNRKRTNN |
PBM
Berger et al.(2008)
Six2_2307
|
0.708
|
0.741
|
Six1
M00512_2.00 |
Mus musculus |
NNDATMYNNN |
NNNRKATHNN |
PBM
Berger et al.(2008)
Six1_0935
|
0.708
|
0.741
|
SIX1
M05094_2.00 |
Homo sapiens |
NNYGATACVB |
VBGTATCRNN |
SELEX
Yin et al.(2017)
SIX1_eDBD_HT-SELEX
|
0.708
|
0.741
|
SIX1
M05096_2.00 |
Homo sapiens |
NNYGATAYVB |
VBRTATCRNN |
SELEX
Yin et al.(2017)
SIX1_FL_HT-SELEX
|
0.708
|
0.741
|
SIX2
M05285_2.00 |
Homo sapiens |
NNYGATACSB |
VSGTATCRNN |
SELEX
Yin et al.(2017)
SIX2_eDBD_HT-SELEX
|
0.708
|
0.741
|
SIX2
M05287_2.00 |
Homo sapiens |
NSGTRWCRYN |
NRYGWYACSN |
SELEX
Yin et al.(2017)
SIX2_FL_HT-SELEX
|
0.708
|
0.741
|
SIX1
M08130_2.00 |
Homo sapiens |
GWAACCTGANM |
KNTCAGGTTWC |
ChIP-seq
Mathelier et al.(2014)
MA1118.1
|
0.708
|
0.741
|
SIX2
M08133_2.00 |
Homo sapiens |
NNNTGWAACCTGAKMH |
DKMTCAGGTTWCANNN |
ChIP-seq
Mathelier et al.(2014)
MA1119.1
|
0.708
|
0.741
|
SIX1
M09142_2.00 |
Homo sapiens |
DGWAAYHTGABMYN |
NRKVTCADRTTWCH |
Misc
Kulakovskiy et al.(2013)
SIX1_HUMAN.H11MO.0.A
|
0.708
|
0.741
|
SIX2
M09157_2.00 |
Homo sapiens |
DGWAAYHHGABMH |
DKVTCDDRTTWCH |
Misc
Kulakovskiy et al.(2013)
SIX2_HUMAN.H11MO.0.A
|
0.708
|
0.741
|
Six2
M09185_2.00 |
Mus musculus |
DGWAAYHYRABMYB |
VRKVTYRDRTTWCH |
Misc
Kulakovskiy et al.(2013)
SIX2_MOUSE.H11MO.0.A
|
0.708
|
0.741
|
Six1
M09579_2.00 |
Mus musculus |
GWAAYHTGABMH |
DKVTCADRTTWC |
Misc
Heinz et al.(2010)
Myoblast-Six1_GSE20150
|
0.708
|
0.741
|
SIX1
M10684_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SIX1_Q3_01
|
0.708
|
0.741
|
SIX1
M10685_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SIX1_Q3
|
0.708
|
0.741
|
SIX1
M05095_2.00 |
Homo sapiens |
NNYGATABNB |
VNVTATCRNN |
SELEX
Yin et al.(2017)
SIX1_eDBD_Methyl-HT-SELEX
|
0.708
|
0.741
|
SIX1
M05097_2.00 |
Homo sapiens |
NNYGATAYSB |
VSRTATCRNN |
SELEX
Yin et al.(2017)
SIX1_FL_Methyl-HT-SELEX
|
0.708
|
0.741
|
SIX2
M05286_2.00 |
Homo sapiens |
NBRTATCRNN |
NNYGATAYVN |
SELEX
Yin et al.(2017)
SIX2_eDBD_Methyl-HT-SELEX
|
0.708
|
0.741
|
SIX2
M05288_2.00 |
Homo sapiens |
VBRTAWCRNN |
NNYGWTAYVB |
SELEX
Yin et al.(2017)
SIX2_FL_Methyl-HT-SELEX
|
0.708
|
0.741
|
so
M02117_2.00 |
Drosophila melanogaster |
NDATMYNNN |
NNNRKATHN |
PBM
Weirauch et al.(2014)
pTH5690
|
0.708
|
0.722
|
so
M03800_2.00 |
Drosophila melanogaster |
NYGATAYB |
VRTATCRN |
SELEX
Nitta et al.(2015)
so_1
|
0.708
|
0.722
|
so
M03801_2.00 |
Drosophila melanogaster |
YKATAYNNNYGATAY |
RTATCRNNNRTATMR |
SELEX
Nitta et al.(2015)
so_2
|
0.708
|
0.722
|
so
M03802_2.00 |
Drosophila melanogaster |
YGATACGTATCR |
YGATACGTATCR |
SELEX
Nitta et al.(2015)
so_3
|
0.708
|
0.722
|
so
M03803_2.00 |
Drosophila melanogaster |
RTATCRYGATAC |
GTATCRYGATAY |
SELEX
Nitta et al.(2015)
so_4
|
0.708
|
0.722
|
so
M06497_2.00 |
Drosophila melanogaster |
TGATAC |
GTATCA |
B1H
Mathelier et al.(2014)
MA0246.1
|
0.708
|
0.722
|
so
M06268_2.00 |
Drosophila melanogaster |
NRTGATA |
TATCAYN |
B1H
Zhu et al.(2011)
So_Cell_FBgn0003460
|
0.708
|
0.722
|
so
M06269_2.00 |
Drosophila melanogaster |
NNNTGATA |
TATCANNN |
B1H
Zhu et al.(2011)
So_SOLEXA_FBgn0003460
|
0.708
|
0.722
|
ceh-34
M00672_2.00 |
Caenorhabditis elegans |
NNNRDAWNNN |
NNNWTHYNNN |
PBM
Narasimhan et al.(2015)
pTH9708
|
0.638
|
0.574
|
For this family, TFs with SR scores > 0.599 will likely have a similar motif |