TF Information

HHAL007396-PA *(Halyomorpha halys)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00046 (Homeobox)	IPR001356	HHAL007396-PA	T229854_2.00	Misc (2018-Jan-19)
NCBI Gene Info: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
CG11085 M03857_2.00	Drosophila melanogaster	BTAAWYGN	NCRWTTAV	SELEX Nitta et al.(2015) CG11085_1	0.684	0.909
CG11085 M03858_2.00	Drosophila melanogaster	NTAAWCGN	NCGWTTAN	SELEX Nitta et al.(2015) CG11085_2	0.684	0.909
CG11085 M06532_2.00	Drosophila melanogaster	TTAATDG	CHATTAA	B1H Mathelier et al.(2014) MA0171.1	0.684	0.909
CG11085 M06339_2.00	Drosophila melanogaster	NTTAATDGV	BCHATTAAN	B1H Zhu et al.(2011) CG11085_Cell_FBgn0030408	0.684	0.909
CG11085 M06340_2.00	Drosophila melanogaster	NHTAAWBRNN	NNYVWTTADN	B1H Zhu et al.(2011) CG11085_SOLEXA_FBgn0030408	0.684	0.909
Gbx2 M00462_2.00	Mus musculus	NNDAHNN	NNDTHNN	PBM Berger et al.(2008) Gbx2_3110	0.641	0.618
Gbx1 M00525_2.00	Mus musculus	NNTAATNR	YNATTANN	PBM Berger et al.(2008) Gbx1_2883	0.641	0.618
GBX1 M03193_2.00	Homo sapiens	NBTAATTRSB	VSYAATTAVN	SELEX Jolma et al.(2013) GBX1_1	0.641	0.618
GBX2 M03201_2.00	Homo sapiens	NNTAATTRNN	NNYAATTANN	SELEX Jolma et al.(2013) GBX2_1	0.641	0.618
GBX2 M03202_2.00	Homo sapiens	TAATTRVBCAATWA	TWATTGVBYAATTA	SELEX Jolma et al.(2013) GBX2_2	0.641	0.618
GBX2 M03203_2.00	Homo sapiens	NNTAATTRNN	NNYAATTANN	SELEX Jolma et al.(2013) GBX2_3	0.641	0.618
Gbx1 M03286_2.00	Mus musculus	NNTAATTRNN	NNYAATTANN	SELEX Jolma et al.(2013) Gbx1_1	0.641	0.618
Gbx2 M03268_2.00	Mus musculus	NNTAATTRNN	NNYAATTANN	SELEX Jolma et al.(2013) Gbx2_1	0.641	0.618
GBX2 M05265_2.00	Homo sapiens	NTAATTRN	NYAATTAN	SELEX Yin et al.(2017) GBX2_eDBD_HT-SELEX	0.641	0.618
GBX2 M05268_2.00	Homo sapiens	NTAATTRV	BYAATTAN	SELEX Yin et al.(2017) GBX2_FL_HT-SELEX	0.641	0.618
GBX2 M05266_2.00	Homo sapiens	HTAAYGAB	VTCRTTAD	SELEX Yin et al.(2017) GBX2_eDBD_Methyl-HT-SELEX_1	0.641	0.618
GBX2 M05267_2.00	Homo sapiens	NTAATTRN	NYAATTAN	SELEX Yin et al.(2017) GBX2_eDBD_Methyl-HT-SELEX_2	0.641	0.618
GBX2 M05269_2.00	Homo sapiens	NTAATTRN	NYAATTAN	SELEX Yin et al.(2017) GBX2_FL_Methyl-HT-SELEX_1	0.641	0.618
GBX2 M05270_2.00	Homo sapiens	NTAAYGAB	VTCRTTAN	SELEX Yin et al.(2017) GBX2_FL_Methyl-HT-SELEX_2	0.641	0.618
unpg M03836_2.00	Drosophila melanogaster	SSTAATYRVN	NBYRATTASS	SELEX Nitta et al.(2015) unpg_1	0.625	0.600
unpg M06517_2.00	Drosophila melanogaster	BTAATTR	YAATTAV	B1H Mathelier et al.(2014) MA0251.1	0.625	0.600
unpg M06311_2.00	Drosophila melanogaster	NBTAATTR	YAATTAVN	B1H Zhu et al.(2011) Unpg_Cell_FBgn0015561	0.625	0.600
unpg M06312_2.00	Drosophila melanogaster	HTAATTR	YAATTAD	B1H Zhu et al.(2011) Unpg_SOLEXA_FBgn0015561	0.625	0.600
Nkx1-2 M00503_2.00	Mus musculus	NNTAAWNDN	NHNWTTANN	PBM Berger et al.(2008) Nkx1-2_3214	0.622	0.582
Nkx1-1 M00442_2.00	Mus musculus	NNTAATNDNN	NNHNATTANN	PBM Berger et al.(2008) Nkx1-1_3856	0.621	0.564
slou M00557_2.00	Drosophila melanogaster	NNTAATDRN	NYHATTANN	PBM Busser et al.(2012a) Slou	0.621	0.564
slou M03798_2.00	Drosophila melanogaster	VBTAATTRSB	VSYAATTAVB	SELEX Nitta et al.(2015) slou_1	0.621	0.564
slou M06494_2.00	Drosophila melanogaster	YTAATKR	YMATTAR	B1H Mathelier et al.(2014) MA0245.1	0.621	0.564
slou M06262_2.00	Drosophila melanogaster	BYTAATKR	YMATTARV	B1H Zhu et al.(2011) Slou_Cell_FBgn0002941	0.621	0.564
slou M06263_2.00	Drosophila melanogaster	HTAATKR	YMATTAD	B1H Zhu et al.(2011) Slou_SOLEXA_FBgn0002941	0.621	0.564
exex M03871_2.00	Drosophila melanogaster	NNNNYAATTNNYDN	NHRNNAATTRNNNN	SELEX Nitta et al.(2015) exex_1	0.621	0.582
exex M06544_2.00	Drosophila melanogaster	BTAATTA	TAATTAV	B1H Mathelier et al.(2014) MA0224.1	0.621	0.582
exex M06364_2.00	Drosophila melanogaster	TAATTAV	BTAATTA	B1H Zhu et al.(2011) Exex_Cell_FBgn0041156	0.621	0.582
exex M06365_2.00	Drosophila melanogaster	TAATBR	YVATTA	B1H Zhu et al.(2011) Exex_SOLEXA_FBgn0041156	0.621	0.582
Mnx1 M00388_2.00	Mus musculus	NTAATBDNNN	NNNHVATTAN	PBM Berger et al.(2008) Hlxb9_3422	0.621	0.564
MNX1 M03143_2.00	Homo sapiens	NHTAATTRNH	DNYAATTADN	SELEX Jolma et al.(2013) MNX1_1	0.621	0.564
MNX1 M05126_2.00	Homo sapiens	NTAATTRN	NYAATTAN	SELEX Yin et al.(2017) MNX1_eDBD_HT-SELEX	0.621	0.564
MNX1 M05127_2.00	Homo sapiens	HTAAYGHB	VDCRTTAD	SELEX Yin et al.(2017) MNX1_eDBD_Methyl-HT-SELEX_1	0.621	0.564
MNX1 M05128_2.00	Homo sapiens	NTAATTRN	NYAATTAN	SELEX Yin et al.(2017) MNX1_eDBD_Methyl-HT-SELEX_2	0.621	0.564
Barhl2 M00460_2.00	Mus musculus	NTAAWNRNN	NNYNWTTAN	PBM Berger et al.(2008) Barhl2_3868	0.619	0.655
BARHL2 M03157_2.00	Homo sapiens	NNTAAWYGNN	NNCRWTTANN	SELEX Jolma et al.(2013) BARHL2_1	0.619	0.655
BARHL2 M03158_2.00	Homo sapiens	NNTAAWBGNN	NNCVWTTANN	SELEX Jolma et al.(2013) BARHL2_2	0.619	0.655
BARHL2 M03159_2.00	Homo sapiens	TAAWYGNNNNTAAWYR	YRWTTANNNNCRWTTA	SELEX Jolma et al.(2013) BARHL2_3	0.619	0.655
BARHL2 M03160_2.00	Homo sapiens	NNTAAWYGNH	DNCRWTTANN	SELEX Jolma et al.(2013) BARHL2_4	0.619	0.655
BARHL2 M03161_2.00	Homo sapiens	NNTAAWYGNN	NNCRWTTANN	SELEX Jolma et al.(2013) BARHL2_5	0.619	0.655
BARHL2 M03162_2.00	Homo sapiens	TAAWYGNYNHTAAWYG	CRWTTADNRNCRWTTA	SELEX Jolma et al.(2013) BARHL2_6	0.619	0.655
BARHL2 M05164_2.00	Homo sapiens	HTAAAYGNY	RNCRTTTAD	SELEX Yin et al.(2017) BARHL2_eDBD_HT-SELEX_1	0.619	0.655
BARHL2 M05165_2.00	Homo sapiens	NTAAWTGNB	VNCAWTTAN	SELEX Yin et al.(2017) BARHL2_eDBD_HT-SELEX_2	0.619	0.655
BARHL2 M05167_2.00	Homo sapiens	NTAAWYGN	NCRWTTAN	SELEX Yin et al.(2017) BARHL2_FL_HT-SELEX_1	0.619	0.655
BARHL2 M05168_2.00	Homo sapiens	NTAAWYGN	NCRWTTAN	SELEX Yin et al.(2017) BARHL2_FL_HT-SELEX_2	0.619	0.655
BARHL2 M05166_2.00	Homo sapiens	NTAAWTGNB	VNCAWTTAN	SELEX Yin et al.(2017) BARHL2_eDBD_Methyl-HT-SELEX	0.619	0.655
BARHL2 M05169_2.00	Homo sapiens	NTAAWTGN	NCAWTTAN	SELEX Yin et al.(2017) BARHL2_FL_Methyl-HT-SELEX	0.619	0.655
ENSTNIG00000006040 M02106_2.00	Tetraodon nigroviridis	NNNBTAAWHRBNN	NNVYDWTTAVNNN	PBM Weirauch et al.(2014) pTH6503	0.617	0.618
HOXA2 M02083_2.00	Homo sapiens	NNNDHHNNN	NNNDDHNNN	PBM Weirauch et al.(2014) pTH5887	0.616	0.491
Hoxa2 M00403_2.00	Mus musculus	NTAATKRNN	NNYMATTAN	PBM Berger et al.(2008) Hoxa2_3079	0.616	0.491
HOXA2 M03097_2.00	Homo sapiens	NBTAATKRNN	NNYMATTAVN	SELEX Jolma et al.(2013) HOXA2_1	0.616	0.491
HOXB2 M03213_2.00	Homo sapiens	NNTAATKRNN	NNYMATTANN	SELEX Jolma et al.(2013) HOXB2_1	0.616	0.491
Hoxa2 M03251_2.00	Mus musculus	NNTAATKRNN	NNYMATTANN	SELEX Jolma et al.(2013) Hoxa2_1	0.616	0.491
pb M03872_2.00	Drosophila melanogaster	NTRAYKRY	RYMRTYAN	SELEX Nitta et al.(2015) pb_1	0.616	0.491
HOXA2 M04962_2.00	Homo sapiens	NTAATKRV	BYMATTAN	SELEX Yin et al.(2017) HOXA2_eDBD_HT-SELEX	0.616	0.491
HOXA2 M04965_2.00	Homo sapiens	NTAATKAB	VTMATTAN	SELEX Yin et al.(2017) HOXA2_FL_HT-SELEX	0.616	0.491
HOXB2 M05292_2.00	Homo sapiens	BTAATKRV	BYMATTAV	SELEX Yin et al.(2017) HOXB2_eDBD_HT-SELEX	0.616	0.491
pb M06545_2.00	Drosophila melanogaster	YTAATKA	TMATTAR	B1H Mathelier et al.(2014) MA0238.1	0.616	0.491
pb M06366_2.00	Drosophila melanogaster	BYTAATKA	TMATTARV	B1H Zhu et al.(2011) Pb_Cell_FBgn0051481	0.616	0.491
pb M06367_2.00	Drosophila melanogaster	YTAATKA	TMATTAR	B1H Zhu et al.(2011) Pb_SOLEXA_FBgn0051481	0.616	0.491
Hoxa2 M09566_2.00	Mus musculus	DTGATKGATKDB	VHMATCMATCAH	Misc Heinz et al.(2010) mES-Hoxa2_Donaldson_et_al.	0.616	0.491
HOXA2 M04963_2.00	Homo sapiens	NTAATTAN	NTAATTAN	SELEX Yin et al.(2017) HOXA2_eDBD_Methyl-HT-SELEX_1	0.616	0.491
HOXA2 M04964_2.00	Homo sapiens	HTAAYGAB	VTCRTTAD	SELEX Yin et al.(2017) HOXA2_eDBD_Methyl-HT-SELEX_2	0.616	0.491
HOXA2 M04966_2.00	Homo sapiens	NTAATKAB	VTMATTAN	SELEX Yin et al.(2017) HOXA2_FL_Methyl-HT-SELEX_1	0.616	0.491
HOXA2 M04967_2.00	Homo sapiens	HTAAYGAB	VTCRTTAD	SELEX Yin et al.(2017) HOXA2_FL_Methyl-HT-SELEX_2	0.616	0.491
HOXB2 M05293_2.00	Homo sapiens	NTAATKRN	NYMATTAN	SELEX Yin et al.(2017) HOXB2_eDBD_Methyl-HT-SELEX_1	0.616	0.491
HOXB2 M05294_2.00	Homo sapiens	HTAAYGAB	VTCRTTAD	SELEX Yin et al.(2017) HOXB2_eDBD_Methyl-HT-SELEX_2	0.616	0.491
Barx1 M00413_2.00	Mus musculus	NNTAAYBDNN	NNHVRTTANN	PBM Berger et al.(2008) Barx1_2877	0.615	0.600
Barx2 M00457_2.00	Mus musculus	NTAABNDNN	NNHNVTTAN	PBM Berger et al.(2008) Barx2_3447	0.615	0.600
barx1 M02107_2.00	Tetraodon nigroviridis	NTAAYNNNN	NNNNRTTAN	PBM Weirauch et al.(2014) pTH6449	0.615	0.600
BARX1 M03144_2.00	Homo sapiens	TAATBGNWWWTTAATBR	YVATTAAWWWNCVATTA	SELEX Jolma et al.(2013) BARX1_1	0.615	0.600
BARX1 M03145_2.00	Homo sapiens	NTAATBRN	NYVATTAN	SELEX Jolma et al.(2013) BARX1_2	0.615	0.600
BARX2 M04915_2.00	Homo sapiens	NTAAYKRTTWWN	NWWAAYMRTTAN	SELEX Yin et al.(2017) BARX2_FL_HT-SELEX	0.615	0.600
Barx1 M09181_2.00	Mus musculus	NNWAAKKGYTWH	DWARCMMTTWNN	Misc Kulakovskiy et al.(2013) BARX1_MOUSE.H11MO.0.C	0.615	0.600
BARX2 M04916_2.00	Homo sapiens	NTAAYKRTTWWN	NWWAAYMRTTAN	SELEX Yin et al.(2017) BARX2_FL_Methyl-HT-SELEX	0.615	0.600
eve M00556_2.00	Drosophila melanogaster	NNTAATTARN	NYTAATTANN	PBM Busser et al.(2012a) Eve	0.613	0.473
eve M02115_2.00	Drosophila melanogaster	NTAATNDNN	NNHNATTAN	PBM Weirauch et al.(2014) pTH6436	0.613	0.473
eve M03794_2.00	Drosophila melanogaster	VYTAATKASN	NSTMATTARB	SELEX Nitta et al.(2015) eve_1	0.613	0.473
eve M06486_2.00	Drosophila melanogaster	YTAATKA	TMATTAR	B1H Mathelier et al.(2014) MA0221.1	0.613	0.473
eve M06240_2.00	Drosophila melanogaster	DYTAATKA	TMATTARH	B1H Zhu et al.(2011) Eve_Cell_FBgn0000606	0.613	0.473
eve M06241_2.00	Drosophila melanogaster	HKBTAAYNDTKY	RMAHNRTTAVMD	B1H Zhu et al.(2011) eve_FlyReg_FBgn0000606	0.613	0.473
eve M06242_2.00	Drosophila melanogaster	NYTAATKA	TMATTARN	B1H Zhu et al.(2011) Eve_SOLEXA_FBgn0000606	0.613	0.473
eve M09678_2.00	Drosophila melanogaster	NKHTAATKD	HMATTADMN	Misc Kulakovskiy et al.(2009) eve	0.613	0.473
eve M10786_2.00	Drosophila melanogaster	Transfac license required	Transfac license required	Transfac Matys et al.(2006) I$EVE_Q6	0.613	0.473
Barhl1 M00433_2.00	Mus musculus	NTAAWNRNN	NNYNWTTAN	PBM Berger et al.(2008) Barhl1_2590	0.609	0.655
Barhl1 M03258_2.00	Mus musculus	NNTAAWYGNH	DNCRWTTANN	SELEX Jolma et al.(2013) Barhl1_1	0.609	0.655
Barhl1 M03259_2.00	Mus musculus	NNTAADNRNN	NNYNHTTANN	SELEX Jolma et al.(2013) Barhl1_2	0.609	0.655
Barhl1 M03260_2.00	Mus musculus	TAAWYGNYNNTAAWYG	CRWTTANNRNCRWTTA	SELEX Jolma et al.(2013) Barhl1_3	0.609	0.655
BARHL1 M05091_2.00	Homo sapiens	NTAAWYGN	NCRWTTAN	SELEX Yin et al.(2017) BARHL1_eDBD_HT-SELEX_1	0.609	0.655
BARHL1 M05092_2.00	Homo sapiens	NTAADBGN	NCVHTTAN	SELEX Yin et al.(2017) BARHL1_eDBD_HT-SELEX_2	0.609	0.655
BARHL1 M05093_2.00	Homo sapiens	NTAADKGN	NCMHTTAN	SELEX Yin et al.(2017) BARHL1_eDBD_Methyl-HT-SELEX	0.609	0.655
B-H2 M03810_2.00	Drosophila melanogaster	VNTAAAYGNH	DNCRTTTANB	SELEX Nitta et al.(2015) B-H2_1	0.606	0.600
B-H2 M03811_2.00	Drosophila melanogaster	SNTAADBGN	NCVHTTANS	SELEX Nitta et al.(2015) B-H2_2	0.606	0.600
B-H2 M06503_2.00	Drosophila melanogaster	WTAATTG	CAATTAW	B1H Mathelier et al.(2014) MA0169.1	0.606	0.600
B-H1 M03829_2.00	Drosophila melanogaster	VNTAAWYGNN	NNCRWTTANB	SELEX Nitta et al.(2015) B-H1_1	0.606	0.582
B-H1 M03830_2.00	Drosophila melanogaster	SNTAADBGN	NCVHTTANS	SELEX Nitta et al.(2015) B-H1_2	0.606	0.582
B-H1 M06512_2.00	Drosophila melanogaster	HTAAWYG	CRWTTAD	B1H Mathelier et al.(2014) MA0168.1	0.606	0.582
NEMVEDRAFT_v1g8907 M02154_2.00	Nematostella vectensis	NTAATDRNNN	NNNYHATTAN	PBM Weirauch et al.(2014) pTH6483	0.601	0.527
For this family, TFs with SR scores > 0.599* will likely have a similar motif*