snap_masked-nMf.1.1.scaf13062-processed-gene-0.2 (Meloidogyne floridensis)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox) IPR001356 snap_masked-nMf.1.1.scaf13062-processed-gene-0.2 T236238_2.00 WormBase:ParaSite (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
snap_masked-nMf.1.1.scaf13062-processed-gene-0.2-mRNA-1 Homeodomain 141 189

Links

Other Homeodomain family TFs
Other Meloidogyne floridensis TFs

16 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ANCDUO_19178 Ancylostoma duodenale ANCDUO_19178 N 0.710
LDEC024564 Leptinotarsa decemlineata LDEC024564 N 0.702
M407DRAFT_77617 Tulasnella calospora M407DRAFT_77617 N 0.680
ORUFI09G21220 Oryza rufipogon ORUFI09G21220 N 0.678
Brh_R000011 Buceros rhinoceros Brh_R000011 I 0.672
ENSECAG00000002506 Equus caballus ENSECAG00000002506 I 0.658
Gfo_R000008 Geospiza fortis Gfo_R000008 N 0.653
SCUD_0000383301 Schistosoma curassoni SCUD_0000383301 N 0.651
ISCW012461 Ixodes scapularis ISCW012461 N 0.651
Ca_23643 Cicer arietinum Ca_23643 N 0.635
Ocbimv22024374m.g Octopus bimaculoides Ocbimv22024374m.g N 0.631
Minc16530 Meloidogyne incognita Minc16530 N 0.619
ECPE_0000850801 Echinostoma caproni ECPE_0000850801 N 0.601
TCNE_0000939301 Toxocara canis TCNE_0000939301 N 0.600
Brh_R008378 Buceros rhinoceros Brh_R008378 I 0.600
RAX2 Microcebus murinus ENSMICG00000014768 I 0.600