pax6b (Danio rerio)
Homeodomain,Paired box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00292 (PAX) 		IPR001356
IPR001523 		ENSDARG00000045936 T237308_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within animal organ development; anterior/posterior pattern specification; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; endocrine system; immature eye; nervous system; and neural plate. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
pax2b
M02425_2.00 		Danio rerio
HVNYSRNSCR
YGSNYSRNBD		 PBM
Weirauch et al.(2014)
pTH8679 		0.778 0.778
PAX6
M00342_2.00 		Homo sapiens
NNNRCDMATTANNN
NNNTAATKHGYNNN		 PBM
Barrera et al.(2016)
PAX6_REF 		0.994 0.994
Pax5B
M01301_2.00 		Gallus gallus
NSNDTNNNN
NNNNAHNSN		 PBM
Lambert et al.(2019)
pTH9781 		0.778 0.778
Pax6
M00540_2.00 		Mus musculus
CBAATTAA
TTAATTVG		 PBM
Berger et al.(2008)
Pax6_3838 		0.994 0.994
pax2
M02428_2.00 		Xenopus tropicalis
NNNRNBCRNN
NNYGVNYNNN		 PBM
Weirauch et al.(2014)
pTH8556 		0.828 0.828
PAX6
M03291_2.00 		Homo sapiens
DTWYACGCWTGANTGMDYH
DRHKCANTCAWGCGTRWAH		 SELEX
Jolma et al.(2013)
PAX6_1 		0.994 0.994
PAX6
M05412_2.00 		Homo sapiens
NYACGCHYSRNYRMNYN
NRNKYRNYSRDGCGTRN		 SELEX
Yin et al.(2017)
PAX6_eDBD_HT-SELEX 		0.995 0.995
PAX5
M03443_2.00 		Homo sapiens
RNBYANYSAWSCGTRACN
NGTYACGSWTSRNTRVNY		 SELEX
Jolma et al.(2013)
PAX5_1 		0.828 0.828
PAX6
M05414_2.00 		Homo sapiens
NYRCGCNYSRNYRVNYN
NRNBYRNYSRNGCGYRN		 SELEX
Yin et al.(2017)
PAX6_FL_HT-SELEX 		0.995 0.995
PAX5
M08160_2.00 		Homo sapiens
RDGCGTGACCNN
NNGGTCACGCHY		 ChIP-seq
Mathelier et al.(2014)
MA0014.3 		0.828 0.828
PAX6
M02689_2.00 		Homo sapiens
TTYACGCWTSANTK
MANTSAWGCGTRAA		 SELEX
Mathelier et al.(2014)
MA0069.1 		0.994 0.994
PAX5
M07995_2.00 		Homo sapiens
BCAVYSRDSCRKRRC
GYYMYGSHYSRBTGV		 ChIP-seq
Gerstein et al.(2012)
GM12878_PAX5C20_HudsonAlpha 		0.828 0.828
PAX6
M09216_2.00 		Homo sapiens
TYMYRCWTSRNT
ANYSAWGYRKRA		 Misc
Kulakovskiy et al.(2013)
PAX6_HUMAN.H11MO.0.C 		0.994 0.994
PAX5
M07996_2.00 		Homo sapiens
BCASYSRDSCRTRAC
GTYAYGSHYSRSTGV		 ChIP-seq
Gerstein et al.(2012)
GM12878_PAX5N19_HudsonAlpha 		0.828 0.828
Pax6
M09217_2.00 		Mus musculus
TYMYRCWTSRNT
ANYSAWGYRKRA		 Misc
Kulakovskiy et al.(2013)
PAX6_MOUSE.H11MO.0.C 		0.994 0.994
PAX5
M07997_2.00 		Homo sapiens
CASYSRDSCRKRACN
NGTYMYGSHYSRSTG		 ChIP-seq
Gerstein et al.(2012)
GM12891_PAX5C20_HudsonAlpha 		0.828 0.828
PAX5
M07998_2.00 		Homo sapiens
BCASYSRDSCGKRRC
GYYMCGSHYSRSTGV		 ChIP-seq
Gerstein et al.(2012)
GM12892_PAX5C20_HudsonAlpha 		0.778 0.778
PAX6
M10806_2.00 		Homo sapiens
NHNNTTYACGCWTSANTKVHH
DDBMANTSAWGCGTRAANNDN		 Transfac
Matys et al.(2006)
V$PAX6_01 		0.994 0.994
PAX5
M08227_2.00 		Homo sapiens
BCANYSRDGCGTRAM
KTYACGCHYSRNTGV		 ChIP-seq
Contrino et al.(2012)
Mv108 		0.778 0.778
PAX6
M10807_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX6_Q2 		0.994 0.994
PAX5
M08228_2.00 		Homo sapiens
AGCGTGRCYG
CRGYCACGCT		 ChIP-seq
Contrino et al.(2012)
Mv109 		0.828 0.828
PAX6
M00336_2.00 		Homo sapiens
RTGCACAC
GTGTGCAY		 PBM
Barrera et al.(2016)
PAX6_F258S 		0.994 0.994
PAX6
M05413_2.00 		Homo sapiens
DYRCGCWTSRNYRMNYN
NRNKYRNYSAWGCGYRH		 SELEX
Yin et al.(2017)
PAX6_eDBD_Methyl-HT-SELEX 		0.995 0.995
PAX6
M05415_2.00 		Homo sapiens
NYACGCHYSRNYRMHYN
NRDKYRNYSRDGCGTRN		 SELEX
Yin et al.(2017)
PAX6_FL_Methyl-HT-SELEX 		0.995 0.995
PAX5
M09341_2.00 		Homo sapiens
SNVDGNKCARCVRAGCRDGAC
GTCHYGCTYBGYTGMNCHBNS		 Misc
Kulakovskiy et al.(2013)
PAX5_HUMAN.H11MO.0.A 		0.828 0.828
PAX6
M00335_2.00 		Homo sapiens
BRNNNNNN
NNNNNNYV		 PBM
Barrera et al.(2016)
PAX6_A79E 		0.989 0.989
Pax5
M09342_2.00 		Mus musculus
VDRNBCAVYVRDSCRKRRM
KYYMYGSHYBRBTGVNYHB		 Misc
Kulakovskiy et al.(2013)
PAX5_MOUSE.H11MO.0.A 		0.828 0.828
PAX5
M09622_2.00 		Homo sapiens
BCASYSRDSCRTGRMN
NKYCAYGSHYSRSTGV		 Misc
Heinz et al.(2010)
GM12878-PAX5_GSE32465_1 		0.828 0.828
PAX6
M00337_2.00 		Homo sapiens
NMTAATTANNN
NNNTAATTAKN		 PBM
Barrera et al.(2016)
PAX6_P118R 		0.988 0.988
PAX5
M09623_2.00 		Homo sapiens
BCABNVRSCGTGAC
GTCACGSYBNVTGV		 Misc
Heinz et al.(2010)
GM12878-PAX5_GSE32465_2 		0.828 0.828
PAX6
M00338_2.00 		Homo sapiens
WSGVRVDR
YHBYBCSW		 PBM
Barrera et al.(2016)
PAX6_P68S 		0.988 0.988
PAX5
M11208_2.00 		Homo sapiens
BCNNNRNKCANBGNWGNRKRGMSRSHNB
VNDSYSKCYMYNCWNCVNTGMNYNNNGV		 Transfac
Matys et al.(2006)
V$PAX5_01 		0.828 0.828
PAX5
M11209_2.00 		Homo sapiens
VRHVDGDNDBBTNRAGCGKRACVRYNVH
DBNRYBGTYMCGCTYNAVVHNHCHBDYB		 Transfac
Matys et al.(2006)
V$PAX5_02 		0.778 0.778
PAX6
M00339_2.00 		Homo sapiens
NNNNSGKVGGHNN
NNDCCBMCSNNNN		 PBM
Barrera et al.(2016)
PAX6_R128C 		0.988 0.988
PAX5
M11210_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX5_06 		0.778 0.778
PAX6
M00340_2.00 		Homo sapiens
NNNNNRN
NYNNNNN		 PBM
Barrera et al.(2016)
PAX6_R242T 		0.988 0.988
PAX5
M11211_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX5_07 		0.828 0.828
PAX6
M00341_2.00 		Homo sapiens
BTSCCCSGSC
GSCSGGGSAV		 PBM
Barrera et al.(2016)
PAX6_R26G 		0.988 0.988
PAX6
M00343_2.00 		Homo sapiens
NNNNCCCVKCNBN
NVNGMBGGGNNNN		 PBM
Barrera et al.(2016)
PAX6_S119R 		0.989 0.989
PAX5
M11212_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX5_Q6 		0.828 0.828
PAX6
M00344_2.00 		Homo sapiens
NNMSASGBYNNN
NNNRVCSTSKNN		 PBM
Barrera et al.(2016)
PAX6_V126D 		0.989 0.989
sv
M01302_2.00 		Drosophila melanogaster
NNNSCRBRDM
KHYVYGSNNN		 PBM
Lambert et al.(2019)
pTH9773 		0.797 0.797
PAX8
M05685_2.00 		Homo sapiens
NRNBYRNYSRWGCGTGACSN
NSGTCACGCWYSRNYRVNYN		 SELEX
Yin et al.(2017)
PAX8_FL_HT-SELEX 		0.752 0.752
ey
M03896_2.00 		Drosophila melanogaster
CKAATTAD
HTAATTMG		 SELEX
Nitta et al.(2015)
ey_1 		0.924 0.924
sv
M03949_2.00 		Drosophila melanogaster
NBCRNYSAWGCGTGACS
SGTCACGCWTSRNYGVN		 SELEX
Nitta et al.(2015)
sv_1 		0.797 0.797
Pax8
M09624_2.00 		Rattus norvegicus
BCAGBCADSCRKGVM
KBCMYGSHTGVCTGV		 Misc
Heinz et al.(2010)
Thyroid-Pax8_GSE26938 		0.752 0.752
ey
M03897_2.00 		Drosophila melanogaster
HTAATCKMATTAD
HTAATKMGATTAD		 SELEX
Nitta et al.(2015)
ey_2 		0.924 0.924
sv
M06438_2.00 		Drosophila melanogaster
RNYSRDSCGTRACNN
NNGTYACGSHYSRNY		 B1H
Zhu et al.(2011)
sv_SOLEXA_5_FBgn0005561 		0.797 0.797
PAX8
M11205_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX8_01 		0.752 0.752
ey
M03898_2.00 		Drosophila melanogaster
WAAYYRRTTN
NAAYYRRTTW		 SELEX
Nitta et al.(2015)
ey_3 		0.924 0.924
PAX8
M11206_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX8_B 		0.752 0.752
PAX8
M05686_2.00 		Homo sapiens
NRNBCRNTSAWSCGYGACNN
NNGTCRCGSWTSANYGVNYN		 SELEX
Yin et al.(2017)
PAX8_FL_Methyl-HT-SELEX 		0.752 0.752
toy
M03899_2.00 		Drosophila melanogaster
TTYACGCWTGASTGMACAN
NTGTKCASTCAWGCGTRAA		 SELEX
Nitta et al.(2015)
toy_1 		0.901 0.901
toy
M03900_2.00 		Drosophila melanogaster
NTYACGCWTSAVTGMRCNN
NNGYKCABTSAWGCGTRAN		 SELEX
Nitta et al.(2015)
toy_2 		0.901 0.901
toy
M03901_2.00 		Drosophila melanogaster
VATTANBHAYGSWYSRN
NYSRWSCRTDVNTAATB		 SELEX
Nitta et al.(2015)
toy_3 		0.901 0.901
pax-2
M00706_2.00 		Caenorhabditis elegans
RMSCRTRACS
SGTYAYGSKY		 PBM
Narasimhan et al.(2015)
pTH10794 		0.766 0.766
Poxm
M03944_2.00 		Drosophila melanogaster
CAVTCAWGCGTGACR
YGTCACGCWTGABTG		 SELEX
Nitta et al.(2015)
Poxm_1 		0.709 0.709
egl-38
M02426_2.00 		Caenorhabditis elegans
ACCGTGAYCAC
GTGRTCACGGT		 PBM
Weirauch et al.(2014)
pTH8981 		0.750 0.750
Poxm
M03945_2.00 		Drosophila melanogaster
NYSAWGCRTRACS
SGTYAYGCWTSRN		 SELEX
Nitta et al.(2015)
Poxm_2 		0.709 0.709
Poxn
M03946_2.00 		Drosophila melanogaster
DGCGTGACSGTCACGSY
RSCGTGACSGTCACGCH		 SELEX
Nitta et al.(2015)
Poxn_1 		0.750 0.750
Poxm
M06436_2.00 		Drosophila melanogaster
NNNNNNMVNHNRNSCRTGA
TCAYGSNYNDNBKNNNNNN		 B1H
Zhu et al.(2011)
Poxm_SOLEXA_5_FBgn0003129 		0.709 0.709
Poxn
M03947_2.00 		Drosophila melanogaster
RSCGKGACSGTTMCGSW
WSCGKAACSGTCMCGSY		 SELEX
Nitta et al.(2015)
Poxn_2 		0.750 0.750
PAX1
M03442_2.00 		Homo sapiens
DBCANTSAWGCGTGACS
SGTCACGCWTSANTGVH		 SELEX
Jolma et al.(2013)
PAX1_1 		0.701 0.701
PAX9
M03444_2.00 		Homo sapiens
NKCANTSAWGCGTGACS
SGTCACGCWTSANTGMN		 SELEX
Jolma et al.(2013)
PAX9_1 		0.701 0.701
Poxn
M03948_2.00 		Drosophila melanogaster
NCGTTCCGGAACGD
HCGTTCCGGAACGN		 SELEX
Nitta et al.(2015)
Poxn_3 		0.750 0.750
PAX1
M05687_2.00 		Homo sapiens
BCRNTSRWGCGTGACSN
NSGTCACGCWYSANYGV		 SELEX
Yin et al.(2017)
PAX1_eDBD_HT-SELEX 		0.701 0.701
Poxn
M06437_2.00 		Drosophila melanogaster
RSCGTGACG
CGTCACGSY		 B1H
Zhu et al.(2011)
Poxn_SOLEXA_5_FBgn0003130 		0.750 0.750
PAX9
M05689_2.00 		Homo sapiens
BHRNYSRDSCGTRACSN
NSGTYACGSHYSRNYDV		 SELEX
Yin et al.(2017)
PAX9_eDBD_HT-SELEX 		0.701 0.701
PAX1
M11207_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX1_B 		0.701 0.701
pax9
M11204_2.00 		Danio rerio Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PAX9_B 		0.701 0.701
PAX7
M00346_2.00 		Homo sapiens
NGTYAYGSHN
NDSCRTRACN		 PBM
Barrera et al.(2016)
PAX7_REF 		0.719 0.719
PAX1
M05688_2.00 		Homo sapiens
BCRNTSAWGCGTGACSN
NSGTCACGCWTSANYGV		 SELEX
Yin et al.(2017)
PAX1_eDBD_Methyl-HT-SELEX 		0.701 0.701
PAX9
M05690_2.00 		Homo sapiens
BCRNTSAWSCGYGACNN
NNGTCRCGSWTSANYGV		 SELEX
Yin et al.(2017)
PAX9_eDBD_Methyl-HT-SELEX 		0.701 0.701
PAX7
M00345_2.00 		Homo sapiens
NSGTCACGSN
NSCGTGACSN		 PBM
Barrera et al.(2016)
PAX7_P112L 		0.719 0.719
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000019067 Paired box 23 147
ENSDARP00000019067 Homeodomain 230 275
ENSDARP00000113616 Paired box 23 99
ENSDARP00000115187 Paired box 5 81
ENSDARP00000115545 Paired box 23 147
ENSDARP00000115545 Homeodomain 230 286
ENSDARP00000116680 Paired box 5 68
ENSDARP00000136269 Paired box 23 160
ENSDARP00000136269 Homeodomain 243 299
ENSDARP00000141728 Paired box 5 134

Links

Other Homeodomain,Paired box family TFs
Other Danio rerio TFs

Invalid Input OrderBy

763 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action