TF Information

Pax6 *(Mus musculus)* Homeodomain,Paired box
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00046 (Homeobox) PF00292 (PAX)	IPR001356 IPR001523	ENSMUSG00000027168	T237407_2.00	Ensembl (2018-Dec-8)	Link out
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Pax6 M00540_2.00	Mus musculus	CBAATTAA	TTAATTVG	PBM Berger et al.(2008) Pax6_3838	(Direct)	(Direct)
Pax6 M09217_2.00	Mus musculus	TYMYRCWTSRNT	ANYSAWGYRKRA	Misc Kulakovskiy et al.(2013) PAX6_MOUSE.H11MO.0.C	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
NEMVEDRAFT_v1g136480 M02147_2.00	Nematostella vectensis	NNNNNNNNNN	NNNNNNNNNN	PBM Weirauch et al.(2014) pTH6103	0.623	0.544
egl-38 M02426_2.00	Caenorhabditis elegans	ACCGTGAYCAC	GTGRTCACGGT	PBM Weirauch et al.(2014) pTH8981	0.929	0.929
pax2b M02425_2.00	Danio rerio	HVNYSRNSCR	YGSNYSRNBD	PBM Weirauch et al.(2014) pTH8679	0.787	0.787
PAX6 M00342_2.00	Homo sapiens	NNNRCDMATTANNN	NNNTAATKHGYNNN	PBM Barrera et al.(2016) PAX6_REF	1.000	1.000
pax-2 M00706_2.00	Caenorhabditis elegans	RMSCRTRACS	SGTYAYGSKY	PBM Narasimhan et al.(2015) pTH10794	0.929	0.929
Pax5B M01301_2.00	Gallus gallus	NSNDTNNNN	NNNNAHNSN	PBM Lambert et al.(2019) pTH9781	0.787	0.787
PAX6 M03291_2.00	Homo sapiens	DTWYACGCWTGANTGMDYH	DRHKCANTCAWGCGTRWAH	SELEX Jolma et al.(2013) PAX6_1	1.000	1.000
pax2 M02428_2.00	Xenopus tropicalis	NNNRNBCRNN	NNYGVNYNNN	PBM Weirauch et al.(2014) pTH8556	0.787	0.787
PAX6 M05412_2.00	Homo sapiens	NYACGCHYSRNYRMNYN	NRNKYRNYSRDGCGTRN	SELEX Yin et al.(2017) PAX6_eDBD_HT-SELEX	1.000	1.000
PAX5 M03443_2.00	Homo sapiens	RNBYANYSAWSCGTRACN	NGTYACGSWTSRNTRVNY	SELEX Jolma et al.(2013) PAX5_1	0.787	0.787
PAX6 M05414_2.00	Homo sapiens	NYRCGCNYSRNYRVNYN	NRNBYRNYSRNGCGYRN	SELEX Yin et al.(2017) PAX6_FL_HT-SELEX	1.000	1.000
sv M01302_2.00	Drosophila melanogaster	NNNSCRBRDM	KHYVYGSNNN	PBM Lambert et al.(2019) pTH9773	0.857	0.857
PAX5 M08160_2.00	Homo sapiens	RDGCGTGACCNN	NNGGTCACGCHY	ChIP-seq Mathelier et al.(2014) MA0014.3	0.787	0.787
PAX6 M02689_2.00	Homo sapiens	TTYACGCWTSANTK	MANTSAWGCGTRAA	SELEX Mathelier et al.(2014) MA0069.1	1.000	1.000
PAX5 M07995_2.00	Homo sapiens	BCAVYSRDSCRKRRC	GYYMYGSHYSRBTGV	ChIP-seq Gerstein et al.(2012) GM12878_PAX5C20_HudsonAlpha	0.787	0.787
PAX5 M07996_2.00	Homo sapiens	BCASYSRDSCRTRAC	GTYAYGSHYSRSTGV	ChIP-seq Gerstein et al.(2012) GM12878_PAX5N19_HudsonAlpha	0.787	0.787
PAX6 M09216_2.00	Homo sapiens	TYMYRCWTSRNT	ANYSAWGYRKRA	Misc Kulakovskiy et al.(2013) PAX6_HUMAN.H11MO.0.C	1.000	1.000
sv M03949_2.00	Drosophila melanogaster	NBCRNYSAWGCGTGACS	SGTCACGCWTSRNYGVN	SELEX Nitta et al.(2015) sv_1	0.857	0.857
PAX5 M07997_2.00	Homo sapiens	CASYSRDSCRKRACN	NGTYMYGSHYSRSTG	ChIP-seq Gerstein et al.(2012) GM12891_PAX5C20_HudsonAlpha	0.787	0.787
sv M06438_2.00	Drosophila melanogaster	RNYSRDSCGTRACNN	NNGTYACGSHYSRNY	B1H Zhu et al.(2011) sv_SOLEXA_5_FBgn0005561	0.857	0.857
PAX5 M07998_2.00	Homo sapiens	BCASYSRDSCGKRRC	GYYMCGSHYSRSTGV	ChIP-seq Gerstein et al.(2012) GM12892_PAX5C20_HudsonAlpha	0.787	0.787
PAX6 M10806_2.00	Homo sapiens	NHNNTTYACGCWTSANTKVHH	DDBMANTSAWGCGTRAANNDN	Transfac Matys et al.(2006) V$PAX6_01	1.000	1.000
PAX5 M08227_2.00	Homo sapiens	BCANYSRDGCGTRAM	KTYACGCHYSRNTGV	ChIP-seq Contrino et al.(2012) Mv108	0.787	0.787
PAX6 M10807_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX6_Q2	1.000	1.000
PAX6 M05413_2.00	Homo sapiens	DYRCGCWTSRNYRMNYN	NRNKYRNYSAWGCGYRH	SELEX Yin et al.(2017) PAX6_eDBD_Methyl-HT-SELEX	1.000	1.000
PAX5 M08228_2.00	Homo sapiens	AGCGTGRCYG	CRGYCACGCT	ChIP-seq Contrino et al.(2012) Mv109	0.787	0.787
PAX6 M05415_2.00	Homo sapiens	NYACGCHYSRNYRMHYN	NRDKYRNYSRDGCGTRN	SELEX Yin et al.(2017) PAX6_FL_Methyl-HT-SELEX	1.000	1.000
PAX5 M09341_2.00	Homo sapiens	SNVDGNKCARCVRAGCRDGAC	GTCHYGCTYBGYTGMNCHBNS	Misc Kulakovskiy et al.(2013) PAX5_HUMAN.H11MO.0.A	0.787	0.787
PAX6 M00335_2.00	Homo sapiens	BRNNNNNN	NNNNNNYV	PBM Barrera et al.(2016) PAX6_A79E	0.995	0.995
Pax5 M09342_2.00	Mus musculus	VDRNBCAVYVRDSCRKRRM	KYYMYGSHYBRBTGVNYHB	Misc Kulakovskiy et al.(2013) PAX5_MOUSE.H11MO.0.A	0.787	0.787
PAX6 M00336_2.00	Homo sapiens	RTGCACAC	GTGTGCAY	PBM Barrera et al.(2016) PAX6_F258S	0.995	0.995
PAX5 M09622_2.00	Homo sapiens	BCASYSRDSCRTGRMN	NKYCAYGSHYSRSTGV	Misc Heinz et al.(2010) GM12878-PAX5_GSE32465_1	0.787	0.787
PAX5 M09623_2.00	Homo sapiens	BCABNVRSCGTGAC	GTCACGSYBNVTGV	Misc Heinz et al.(2010) GM12878-PAX5_GSE32465_2	0.787	0.787
PAX6 M00337_2.00	Homo sapiens	NMTAATTANNN	NNNTAATTAKN	PBM Barrera et al.(2016) PAX6_P118R	0.995	0.995
PAX5 M11208_2.00	Homo sapiens	BCNNNRNKCANBGNWGNRKRGMSRSHNB	VNDSYSKCYMYNCWNCVNTGMNYNNNGV	Transfac Matys et al.(2006) V$PAX5_01	0.787	0.787
PAX6 M00338_2.00	Homo sapiens	WSGVRVDR	YHBYBCSW	PBM Barrera et al.(2016) PAX6_P68S	0.995	0.995
PAX5 M11209_2.00	Homo sapiens	VRHVDGDNDBBTNRAGCGKRACVRYNVH	DBNRYBGTYMCGCTYNAVVHNHCHBDYB	Transfac Matys et al.(2006) V$PAX5_02	0.787	0.787
PAX6 M00339_2.00	Homo sapiens	NNNNSGKVGGHNN	NNDCCBMCSNNNN	PBM Barrera et al.(2016) PAX6_R128C	0.995	0.995
PAX5 M11210_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX5_06	0.787	0.787
PAX6 M00340_2.00	Homo sapiens	NNNNNRN	NYNNNNN	PBM Barrera et al.(2016) PAX6_R242T	0.995	0.995
PAX6 M00341_2.00	Homo sapiens	BTSCCCSGSC	GSCSGGGSAV	PBM Barrera et al.(2016) PAX6_R26G	0.995	0.995
PAX5 M11211_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX5_07	0.787	0.787
PAX6 M00343_2.00	Homo sapiens	NNNNCCCVKCNBN	NVNGMBGGGNNNN	PBM Barrera et al.(2016) PAX6_S119R	0.995	0.995
PAX5 M11212_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX5_Q6	0.787	0.787
PAX6 M00344_2.00	Homo sapiens	NNMSASGBYNNN	NNNRVCSTSKNN	PBM Barrera et al.(2016) PAX6_V126D	0.995	0.995
PAX8 M05685_2.00	Homo sapiens	NRNBYRNYSRWGCGTGACSN	NSGTCACGCWYSRNYRVNYN	SELEX Yin et al.(2017) PAX8_FL_HT-SELEX	0.762	0.762
ey M03896_2.00	Drosophila melanogaster	CKAATTAD	HTAATTMG	SELEX Nitta et al.(2015) ey_1	0.934	0.934
Pax8 M09624_2.00	Rattus norvegicus	BCAGBCADSCRKGVM	KBCMYGSHTGVCTGV	Misc Heinz et al.(2010) Thyroid-Pax8_GSE26938	0.762	0.762
PAX8 M11205_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX8_01	0.762	0.762
ey M03897_2.00	Drosophila melanogaster	HTAATCKMATTAD	HTAATKMGATTAD	SELEX Nitta et al.(2015) ey_2	0.934	0.934
PAX8 M11206_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX8_B	0.762	0.762
ey M03898_2.00	Drosophila melanogaster	WAAYYRRTTN	NAAYYRRTTW	SELEX Nitta et al.(2015) ey_3	0.934	0.934
PAX8 M05686_2.00	Homo sapiens	NRNBCRNTSAWSCGYGACNN	NNGTCRCGSWTSANYGVNYN	SELEX Yin et al.(2017) PAX8_FL_Methyl-HT-SELEX	0.762	0.762
toy M03899_2.00	Drosophila melanogaster	TTYACGCWTGASTGMACAN	NTGTKCASTCAWGCGTRAA	SELEX Nitta et al.(2015) toy_1	0.907	0.907
Poxn M03946_2.00	Drosophila melanogaster	DGCGTGACSGTCACGSY	RSCGTGACSGTCACGCH	SELEX Nitta et al.(2015) Poxn_1	0.786	0.786
toy M03900_2.00	Drosophila melanogaster	NTYACGCWTSAVTGMRCNN	NNGYKCABTSAWGCGTRAN	SELEX Nitta et al.(2015) toy_2	0.907	0.907
toy M03901_2.00	Drosophila melanogaster	VATTANBHAYGSWYSRN	NYSRWSCRTDVNTAATB	SELEX Nitta et al.(2015) toy_3	0.907	0.907
Poxn M03947_2.00	Drosophila melanogaster	RSCGKGACSGTTMCGSW	WSCGKAACSGTCMCGSY	SELEX Nitta et al.(2015) Poxn_2	0.786	0.786
Poxn M03948_2.00	Drosophila melanogaster	NCGTTCCGGAACGD	HCGTTCCGGAACGN	SELEX Nitta et al.(2015) Poxn_3	0.786	0.786
Poxn M06437_2.00	Drosophila melanogaster	RSCGTGACG	CGTCACGSY	B1H Zhu et al.(2011) Poxn_SOLEXA_5_FBgn0003130	0.786	0.786
Poxm M03944_2.00	Drosophila melanogaster	CAVTCAWGCGTGACR	YGTCACGCWTGABTG	SELEX Nitta et al.(2015) Poxm_1	0.713	0.713
PAX1 M03442_2.00	Homo sapiens	DBCANTSAWGCGTGACS	SGTCACGCWTSANTGVH	SELEX Jolma et al.(2013) PAX1_1	0.714	0.714
Poxm M03945_2.00	Drosophila melanogaster	NYSAWGCRTRACS	SGTYAYGCWTSRN	SELEX Nitta et al.(2015) Poxm_2	0.713	0.713
Poxm M06436_2.00	Drosophila melanogaster	NNNNNNMVNHNRNSCRTGA	TCAYGSNYNDNBKNNNNNN	B1H Zhu et al.(2011) Poxm_SOLEXA_5_FBgn0003129	0.713	0.713
PAX9 M03444_2.00	Homo sapiens	NKCANTSAWGCGTGACS	SGTCACGCWTSANTGMN	SELEX Jolma et al.(2013) PAX9_1	0.714	0.714
PAX1 M05687_2.00	Homo sapiens	BCRNTSRWGCGTGACSN	NSGTCACGCWYSANYGV	SELEX Yin et al.(2017) PAX1_eDBD_HT-SELEX	0.714	0.714
PAX9 M05689_2.00	Homo sapiens	BHRNYSRDSCGTRACSN	NSGTYACGSHYSRNYDV	SELEX Yin et al.(2017) PAX9_eDBD_HT-SELEX	0.705	0.705
PAX1 M11207_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX1_B	0.705	0.705
pax9 M11204_2.00	Danio rerio	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$PAX9_B	0.705	0.705
PAX1 M05688_2.00	Homo sapiens	BCRNTSAWGCGTGACSN	NSGTCACGCWTSANYGV	SELEX Yin et al.(2017) PAX1_eDBD_Methyl-HT-SELEX	0.705	0.705
PAX9 M05690_2.00	Homo sapiens	BCRNTSAWSCGYGACNN	NNGTCRCGSWTSANYGV	SELEX Yin et al.(2017) PAX9_eDBD_Methyl-HT-SELEX	0.705	0.705
For this family, TFs with SR scores > 0.700* will likely have a similar motif*

Experimental Constructs

Motif ID	Domain	From	To	Sequence
M00540_2.00	Paired box	4	128	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
M00540_2.00	Homeodomain	211	267	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSMUSP00000087870	Paired box	4	142	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000087870	Homeodomain	225	281	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000087878	Paired box	4	128	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000087878	Homeodomain	211	267	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000106711	Paired box	4	128	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000106711	Homeodomain	211	267	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000106712	Paired box	4	128	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000106712	Homeodomain	211	267	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000106714	Paired box	4	142	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000106714	Homeodomain	225	281	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000106715	Paired box	4	142	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000106715	Homeodomain	225	281	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000106716	Paired box	4	128	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000106716	Homeodomain	211	267	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000106717	Homeodomain	40	96	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000119375	Paired box	4	139	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINR
ENSMUSP00000129344	Paired box	4	142	SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR
ENSMUSP00000129344	Homeodomain	225	281	QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR
ENSMUSP00000139168	Paired box	4	17	SHSGVNQLGGVFVN

Links
Other Homeodomain,Paired box family TFs
Other *Mus musculus* TFs

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878 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action

Pax6 (Mus musculus) Homeodomain,Paired box

TF Information

Directly determined binding motifs

Motifs from related TFs

Experimental Constructs

DNA Binding Domains

Links

878 Related TFs

Invalid Input OrderBy

Pax6 **(Mus musculus)
Homeodomain,Paired box**