ENSBTAP00000042667-D1 (Bos grunniens)
Homeodomain,Paired box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox)
PF00292 (PAX)
IPR001356
IPR001523
ENSBTAP00000042667-D1 T237702_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Pax4
M00542_2.00
Mus musculus
NNNATTAN

NTAATNNN
PBM
Berger et al.(2008)
Pax4_3989
0.945 0.945
PAX4
M00350_2.00
Homo sapiens
NNNATTAN

NTAATNNN
PBM
Barrera et al.(2016)
PAX4_REF
0.934 0.934
PAX4
M00351_2.00
Homo sapiens
NNNATTAN

NTAATNNN
PBM
Barrera et al.(2016)
PAX4_REF_R3
0.934 0.934
PAX4
M03295_2.00
Homo sapiens
HKAATTAR

YTAATTMD
SELEX
Jolma et al.(2013)
PAX4_1
0.934 0.934
PAX4
M03296_2.00
Homo sapiens
YKAATTAV

BTAATTMR
SELEX
Jolma et al.(2013)
PAX4_2
0.934 0.934
PAX4
M03883_2.00
Homo sapiens
SGTCACGCWTSRNTG

CANYSAWGCGTGACS
SELEX
Nitta et al.(2015)
PAX4_1
0.934 0.934
PAX4
M03884_2.00
Homo sapiens
NNAATTANYKAATDMV

BKHATTMRNTAATTNN
SELEX
Nitta et al.(2015)
PAX4_2
0.934 0.934
PAX4
M05430_2.00
Homo sapiens
NAATTANNNNNNVNTAATTN

NAATTANBNNNNNNTAATTN
SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_1
0.934 0.934
PAX4
M05431_2.00
Homo sapiens
NRYTWYACGCWTSRNYRNNYV

BRNNYRNYSAWGCGTRWARYN
SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_2
0.934 0.934
PAX4
M05432_2.00
Homo sapiens
NTYACGCWYSRNYKMVYN

NRBKMRNYSRWGCGTRAN
SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_3
0.934 0.934
PAX4
M05433_2.00
Homo sapiens
WHACGSTMATTDR

YHAATKASCGTDW
SELEX
Yin et al.(2017)
PAX4_eDBD_HT-SELEX_4
0.934 0.934
PAX4
M10811_2.00
Homo sapiens
NVNBSNNYVCGCHTSAMBNCN

NGNVKTSADGCGBRNNSVNBN
Transfac
Matys et al.(2006)
V$PAX4_01
0.934 0.934
PAX4
M10812_2.00
Homo sapiens
NAHWAATTDVV

BBHAATTWDTN
Transfac
Matys et al.(2006)
V$PAX4_02
0.934 0.934
PAX4
M10813_2.00
Homo sapiens
NDNNHYCACCCB

VGGGTGRDNNHN
Transfac
Matys et al.(2006)
V$PAX4_03
0.934 0.934
PAX4
M10814_2.00
Homo sapiens
RRAAAWWRNNHHNVHHNVHVNNHHSAYHSB

VSDRTSDDNNBDBNDDBNDDNNYWWTTTYY
Transfac
Matys et al.(2006)
V$PAX4_04
0.934 0.934
PAX4
M10815_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX4_Q2
0.934 0.934
PAX4
M05434_2.00
Homo sapiens
NHATTANBTAATDN

NHATTAVNTAATDN
SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_1
0.934 0.934
PAX4
M05435_2.00
Homo sapiens
VATTWYACGCWTSRNYDVNYN

NRNBHRNYSAWGCGTRWAATB
SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_2
0.934 0.934
PAX4
M05436_2.00
Homo sapiens
HTYACGCWTSANYGMNYN

NRNKCRNTSAWGCGTRAD
SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_3
0.934 0.934
PAX4
M05437_2.00
Homo sapiens
DHRYGCTAATTAN

NTAATTAGCRYDH
SELEX
Yin et al.(2017)
PAX4_eDBD_Methyl-HT-SELEX_4
0.934 0.934
PAX4
M00347_2.00
Homo sapiens
NNNATND

HNATNNN
PBM
Barrera et al.(2016)
PAX4_R183C
0.929 0.929
PAX4
M00348_2.00
Homo sapiens
NNDATTAN

NTAATHNN
PBM
Barrera et al.(2016)
PAX4_R192H
0.929 0.929
PAX4
M00349_2.00
Homo sapiens
NNNATTANN

NNTAATNNN
PBM
Barrera et al.(2016)
PAX4_R192S
0.929 0.929
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000042667-D1 Paired box 5 129
ENSBTAP00000042667-D1 Homeodomain 171 227

Links

Other Homeodomain,Paired box family TFs
Other Bos grunniens TFs

42 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
PAX4 Bos taurus ENSBTAG00000000410 I 0.989
ENSOARG00000001951 Ovis aries ENSOARG00000001951 I 0.978
PAX4 Microcebus murinus ENSMICG00000000095 I 0.978
PAX4 Procavia capensis ENSPCAG00000016257 I 0.973
PAX4 Sus scrofa ENSSSCG00000016591 I 0.973
PAX4 Canis familiaris ENSCAFG00000001719 I 0.973
PAX4 Callithrix jacchus ENSCJAG00000017652 I 0.973
Myotis_brandtii_Pax4_10010526 Myotis brandtii Myotis_brandtii_Pax4_10010526 I 0.967
ENSAMEG00000004648 Ailuropoda melanoleuca ENSAMEG00000004648 I 0.967
ENSPPYG00000017971 Pongo abelii ENSPPYG00000017971 I 0.967
ENSCSAG00000010195 Chlorocebus sabaeus ENSCSAG00000010195 I 0.966
PAX4 Loxodonta africana ENSLAFG00000005297 I 0.965
ENSMPUG00000006575 Mustela putorius furo ENSMPUG00000006575 I 0.962
PAX4 Oryctolagus cuniculus ENSOCUG00000001612 I 0.962
PAX4 Macaca mulatta ENSMMUG00000015429 I 0.962
ENSP00000368014 Macaca fascicularis ENSP00000368014 I 0.962
PAX4 Tursiops truncatus ENSTTRG00000006056 I 0.962
ENSNLEG00000012257 Nomascus leucogenys ENSNLEG00000012257 I 0.962
PAX4 Equus caballus ENSECAG00000008343 I 0.962
PAX4 Gorilla gorilla ENSGGOG00000002555 I 0.962
PAX4 Otolemur garnettii ENSOGAG00000013348 I 0.956
PAX4 Pteropus vampyrus ENSPVAG00000013944 I 0.956
PAX4 Felis catus ENSFCAG00000005485 I 0.956
PAX4 Pan troglodytes ENSPTRG00000019653 I 0.956
PAX4 Homo sapiens ENSG00000106331 D 0.956
Pax4 Rattus norvegicus ENSRNOG00000008020 I 0.951
ENSSTOG00000002127 Ictidomys tridecemlineatus ENSSTOG00000002127 I 0.945
PAX4 Cavia porcellus ENSCPOG00000006244 I 0.945
Pax4 Mus musculus ENSMUSG00000029706 D 0.945
Pax4 Dipodomys ordii ENSDORG00000000332 I 0.940
PAX4 Erinaceus europaeus ENSEEUG00000009616 I 0.939
PAX4 Choloepus hoffmanni ENSCHOG00000009265 I 0.920
PAX4 Sorex araneus ENSSARG00000004842 I 0.901
PAX4 Ochotona princeps ENSOPRG00000013381 I 0.901
ENSSHAG00000015143 Sarcophilus harrisii ENSSHAG00000015143 I 0.852
ENSDNOG00000030639 Dasypus novemcinctus ENSDNOG00000030639 I 0.852
PAX4 Myotis lucifugus ENSMLUG00000030302 I 0.830
PAX4 Ornithorhynchus anatinus ENSOANG00000000819 I 0.817
Afo_R008534 Aptenodytes forsteri Afo_R008534 I 0.753
Alligator_sinensis_CCG000926.1 Alligator sinensis Alligator_sinensis_CCG000926.1 I 0.717
ENSXMAG00000014260 Xiphophorus maculatus ENSXMAG00000014260 I 0.703
pax6b Oryzias latipes ENSORLG00000009913 I 0.703