POU1F1 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou)
IPR001356
IPR000327
ENSG00000064835 T238189_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
POU1F1
M03300_2.00
Homo sapiens
NNNWTGMATAWWYHANN

NNTDRWWTATKCAWNNN
SELEX
Jolma et al.(2013)
POU1F1_1
(Direct) (Direct)
POU1F1
M03301_2.00
Homo sapiens
DWTATGCWAATKAD

HTMATTWGCATAWH
SELEX
Jolma et al.(2013)
POU1F1_2
(Direct) (Direct)
POU1F1
M05453_2.00
Homo sapiens
NTAATKAKATGCRN

NYGCATMTMATTAN
SELEX
Yin et al.(2017)
POU1F1_eDBD_HT-SELEX_1
(Direct) (Direct)
POU1F1
M05454_2.00
Homo sapiens
NYGMATAAATTAN

NTAATTTATKCRN
SELEX
Yin et al.(2017)
POU1F1_eDBD_HT-SELEX_2
(Direct) (Direct)
POU1F1
M05455_2.00
Homo sapiens
DTATGCWAATKAVN

NBTMATTWGCATAH
SELEX
Yin et al.(2017)
POU1F1_eDBD_HT-SELEX_3
(Direct) (Direct)
POU1F1
M05456_2.00
Homo sapiens
NTAATGAKATGCRH

DYGCATMTCATTAN
SELEX
Yin et al.(2017)
POU1F1_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
POU1F1
M05457_2.00
Homo sapiens
DCGMATAAATTAN

NTAATTTATKCGH
SELEX
Yin et al.(2017)
POU1F1_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
POU1F1
M05458_2.00
Homo sapiens
WTATGCWAATKAGN

NCTMATTWGCATAW
SELEX
Yin et al.(2017)
POU1F1_eDBD_Methyl-HT-SELEX_3
(Direct) (Direct)
POU1F1
M10822_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PIT1_Q6_01
(Direct) (Direct)
POU1F1
M10823_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PIT1_Q6
(Direct) (Direct)
POU1F1
M10824_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$POU1F1_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.993 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000263781 POU 127 198
ENSP00000263781 Homeodomain 215 271
ENSP00000342931 POU 153 224
ENSP00000342931 Homeodomain 241 297
ENSP00000452610 POU 127 156
ENSP00000454072 POU 65 123
ENSP00000454072 Homeodomain 140 196

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
POU2F1 Anolis carolinensis ENSACAG00000009565 I 0.000
ENSAPLG00000005929 Anas platyrhynchos ENSAPLG00000005929 I 0.000
POU2F1 Bos taurus ENSBTAG00000024534 I 0.000
POU2F1 Choloepus hoffmanni ENSCHOG00000004638 I 0.000
POU2F1 Callithrix jacchus ENSCJAG00000017095 I 0.000
ENSCSAG00000010919 Chlorocebus sabaeus ENSCSAG00000010919 I 0.000
pou2f1b Danio rerio ENSDARG00000007996 I 0.000
POU2F1 Dasypus novemcinctus ENSDNOG00000004060 I 0.000
POU2F1 Equus caballus ENSECAG00000009395 I 0.000
POU2F1 Echinops telfairi ENSETEG00000017919 I 0.000
POU2F1 Homo sapiens ENSG00000143190 D 0.000
POU2F1 Gallus gallus ENSGALG00000015446 I 0.000
POU2F1 Gorilla gorilla ENSGGOG00000016243 I 0.000
POU2F1 Loxodonta africana ENSLAFG00000018204 I 0.000
ENSLOCG00000009711 Lepisosteus oculatus ENSLOCG00000009711 I 0.000
POU2F1 Meleagris gallopavo ENSMGAG00000014434 I 0.000
POU2F1 Microcebus murinus ENSMICG00000011644 I 0.000
POU2F1 Macaca mulatta ENSMMUG00000008155 I 0.000
POU2F1 Monodelphis domestica ENSMODG00000002572 I 0.000
ENSNLEG00000014790 Nomascus leucogenys ENSNLEG00000014790 I 0.000
ENSOARG00000012010 Ovis aries ENSOARG00000012010 I 0.000
ENSONIG00000014184 Oreochromis niloticus ENSONIG00000014184 I 0.000
ENSP00000356836 Macaca fascicularis ENSP00000356836 I 0.000
ENSP00000356836-D1 Bos grunniens ENSP00000356836-D1 I 0.000
ENSPANG00000006362 Papio anubis ENSPANG00000006362 I 0.000
ENSPPYG00000000552 Pongo abelii ENSPPYG00000000552 I 0.000
ENSPSIG00000009591 Pelodiscus sinensis ENSPSIG00000009591 I 0.000
POU2F1 Pan troglodytes ENSPTRG00000001633 I 0.000
POU2F1 Sus scrofa ENSSSCG00000006310 I 0.000
POU2F1 Tupaia belangeri ENSTBEG00000003121 I 0.000
POU2F1 Vicugna pacos ENSVPAG00000000081 I 0.000
pou2f1 Xenopus tropicalis XB-GENE-853992 I 0.000
pou2f1.S Xenopus laevis XB-GENE-853997 I 0.000