POU4F3 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSG00000091010 T238190_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU4F3
M00360_2.00		 Homo sapiens
NNNVNDN
NHNBNNN		 PBM
Barrera et al.(2016)
POU4F3_L289F		 (Direct) (Direct)
POU4F3
M00361_2.00		 Homo sapiens
NHATKHAN
NTDMATDN		 PBM
Barrera et al.(2016)
POU4F3_REF		 (Direct) (Direct)
POU4F3
M03302_2.00		 Homo sapiens
NNHATHAATWATKCAN
NTGMATWATTDATDNN		 SELEX
Jolma et al.(2013)
POU4F3_1		 (Direct) (Direct)
POU4F3
M05459_2.00		 Homo sapiens
DTDMATWATKHAY
RTDMATWATKHAH		 SELEX
Yin et al.(2017)
POU4F3_eDBD_HT-SELEX_1		 (Direct) (Direct)
POU4F3
M05460_2.00		 Homo sapiens
DTGCATWATKNAB
VTNMATWATGCAH		 SELEX
Yin et al.(2017)
POU4F3_eDBD_HT-SELEX_2		 (Direct) (Direct)
POU4F3
M05461_2.00		 Homo sapiens
WTRMATWATTDAY
RTHAATWATKYAW		 SELEX
Yin et al.(2017)
POU4F3_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU4F3
M05462_2.00		 Homo sapiens
THATGCATDA
THATGCATDA		 SELEX
Yin et al.(2017)
POU4F3_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
POU4F3
M05463_2.00		 Homo sapiens
RTRMATWATKYAB
VTRMATWATKYAY		 SELEX
Yin et al.(2017)
POU4F3_FL_HT-SELEX_1		 (Direct) (Direct)
POU4F3
M05464_2.00		 Homo sapiens
ATRMATWATKNAY
RTNMATWATKYAT		 SELEX
Yin et al.(2017)
POU4F3_FL_HT-SELEX_2		 (Direct) (Direct)
POU4F3
M05465_2.00		 Homo sapiens
MTVHATWATKBAN
NTVMATWATDBAK		 SELEX
Yin et al.(2017)
POU4F3_FL_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU4F3
M05466_2.00		 Homo sapiens
DTRMATWATTNAY
RTNAATWATKYAH		 SELEX
Yin et al.(2017)
POU4F3_FL_Methyl-HT-SELEX_2		 (Direct) (Direct)
POU4F3
M10825_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU4F3_Q5		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pou4f3
M00547_2.00 		Mus musculus
NHATDHDN
NHDHATDN		 PBM
Berger et al.(2008)
Pou4f3_2791 		1.000 1.000
For this family, TFs with SR scores > 0.993 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00360_2.00 POU 19 93
M00360_2.00 Homeodomain 112 168
M00361_2.00 POU 19 93
M00361_2.00 Homeodomain 112 168

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000230732 POU 182 256
ENSP00000230732 Homeodomain 275 331

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

42 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action