POU2F1 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSG00000143190 T238193_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU2F1
M00377_2.00		 Homo sapiens
NNTGMAWAWN
NWTWTKCANN		 PBM
Berger et al.(2006)
Oct-1		 (Direct) (Direct)
POU2F1
M03308_2.00		 Homo sapiens
NDTATGYWAATN
NATTWRCATAHN		 SELEX
Jolma et al.(2013)
POU2F1_1		 (Direct) (Direct)
POU2F1
M03309_2.00		 Homo sapiens
HHTRMATATKCAWN
NWTGMATATKYADD		 SELEX
Jolma et al.(2013)
POU2F1_2		 (Direct) (Direct)
POU2F1
M09219_2.00		 Homo sapiens
RNKBVHATGSAAWYVW
WBRWTTSCATDBVMNY		 Misc
Kulakovskiy et al.(2013)
PO2F1_HUMAN.H11MO.0.C		 (Direct) (Direct)
POU2F1
M10826_2.00		 Homo sapiens
NNVNDTATGCAAATNYNNN
NNNRNATTTGCATAHNBNN		 Transfac
Matys et al.(2006)
V$OCT1_01		 (Direct) (Direct)
POU2F1
M10827_2.00		 Homo sapiens
NNNNTGMATATTCNB
VNGAATATKCANNNN		 Transfac
Matys et al.(2006)
V$OCT1_02		 (Direct) (Direct)
POU2F1
M10828_2.00		 Homo sapiens
NNNRTAATNRNDN
NHNYNATTAYNNN		 Transfac
Matys et al.(2006)
V$OCT1_03		 (Direct) (Direct)
POU2F1
M10829_2.00		 Homo sapiens
DHDNDNNHATGYAWAWNHNWNNW
WNNWNDNWTWTRCATDNNHNHDH		 Transfac
Matys et al.(2006)
V$OCT1_04		 (Direct) (Direct)
POU2F1
M10830_2.00		 Homo sapiens
RRTATGCWAATBMK
MKVATTWGCATAYY		 Transfac
Matys et al.(2006)
V$OCT1_05		 (Direct) (Direct)
POU2F1
M10831_2.00		 Homo sapiens
NRYATSWMAWWNWS
SWNAWTKWSATRYN		 Transfac
Matys et al.(2006)
V$OCT1_06		 (Direct) (Direct)
POU2F1
M10832_2.00		 Homo sapiens
WNTATGBTAATT
AATTAVCATANW		 Transfac
Matys et al.(2006)
V$OCT1_07		 (Direct) (Direct)
POU2F1
M10833_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$OCT1_B		 (Direct) (Direct)
POU2F1
M10834_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$OCT1_Q5_01		 (Direct) (Direct)
POU2F1
M10835_2.00		 Homo sapiens
VDVHATGCAAAKNMB
VKNMTTTGCATDBHB		 Transfac
Matys et al.(2006)
V$OCT1_Q6		 (Direct) (Direct)
POU2F1
M10836_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU2F1_Q4_01		 (Direct) (Direct)
POU2F1
M10837_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU2F1_Q4		 (Direct) (Direct)
POU2F1
M10838_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$POU2F1_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.993 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00377_2.00 POU 283 354
M00377_2.00 Homeodomain 380 436

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000356836 POU 295 366
ENSP00000356836 Homeodomain 392 448
ENSP00000356840 POU 306 377
ENSP00000356840 Homeodomain 403 459
ENSP00000401217 POU 243 314
ENSP00000401217 Homeodomain 340 396
ENSP00000414660 POU 235 308
ENSP00000414660 Homeodomain 334 390
ENSP00000415993 POU 191 262
ENSP00000415993 Homeodomain 288 344
ENSP00000441285 POU 283 354
ENSP00000441285 Homeodomain 380 436

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

33 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000006362 Papio anubis ENSPANG00000006362 I 1.000
ENSPPYG00000000552 Pongo abelii ENSPPYG00000000552 I 1.000
ENSPSIG00000009591 Pelodiscus sinensis ENSPSIG00000009591 I 1.000
ENSONIG00000014184 Oreochromis niloticus ENSONIG00000014184 I 1.000
ENSOARG00000012010 Ovis aries ENSOARG00000012010 I 1.000
POU2F1 Monodelphis domestica ENSMODG00000002572 I 1.000
ENSNLEG00000014790 Nomascus leucogenys ENSNLEG00000014790 I 1.000
POU2F1 Pan troglodytes ENSPTRG00000001633 I 1.000
POU2F1 Sus scrofa ENSSSCG00000006310 I 1.000
pou2f1 Xenopus tropicalis XB-GENE-853992 I 1.000
pou2f1.S Xenopus laevis XB-GENE-853997 I 1.000
ENSP00000356836 Macaca fascicularis ENSP00000356836 I 1.000
ENSP00000356836-D1 Bos grunniens ENSP00000356836-D1 I 1.000
POU2F1 Tupaia belangeri ENSTBEG00000003121 I 1.000
POU2F1 Vicugna pacos ENSVPAG00000000081 I 1.000
POU2F1 Macaca mulatta ENSMMUG00000008155 I 1.000
POU2F1 Microcebus murinus ENSMICG00000011644 I 1.000
ENSCSAG00000010919 Chlorocebus sabaeus ENSCSAG00000010919 I 1.000
pou2f1b Danio rerio ENSDARG00000007996 I 1.000
POU2F1 Dasypus novemcinctus ENSDNOG00000004060 I 1.000
POU2F1 Callithrix jacchus ENSCJAG00000017095 I 1.000
POU2F1 Choloepus hoffmanni ENSCHOG00000004638 I 1.000
ENSAPLG00000005929 Anas platyrhynchos ENSAPLG00000005929 I 1.000
POU2F1 Bos taurus ENSBTAG00000024534 I 1.000
POU2F1 Equus caballus ENSECAG00000009395 I 1.000
POU2F1 Echinops telfairi ENSETEG00000017919 I 1.000
ENSLOCG00000009711 Lepisosteus oculatus ENSLOCG00000009711 I 1.000
POU2F1 Meleagris gallopavo ENSMGAG00000014434 I 1.000
POU2F1 Loxodonta africana ENSLAFG00000018204 I 1.000
POU2F1 Gorilla gorilla ENSGGOG00000016243 I 1.000
POU2F1 Gallus gallus ENSGALG00000015446 I 1.000
POU2F1 Anolis carolinensis ENSACAG00000009565 I 1.000