POU3F4 (Homo sapiens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSG00000196767 T238198_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU3F4
M00364_2.00		 Homo sapiens
NWWTNNN
NNNAWWN		 PBM
Barrera et al.(2016)
POU3F4_A312V		 (Direct) (Direct)
POU3F4
M00365_2.00		 Homo sapiens
NNNDWDN
NHWHNNN		 PBM
Barrera et al.(2016)
POU3F4_R323G		 (Direct) (Direct)
POU3F4
M00366_2.00		 Homo sapiens
NWATKHN
NDMATWN		 PBM
Barrera et al.(2016)
POU3F4_REF		 (Direct) (Direct)
POU3F4
M03317_2.00		 Homo sapiens
TATGCWAAT
ATTWGCATA		 SELEX
Jolma et al.(2013)
POU3F4_1		 (Direct) (Direct)
POU3F4
M03318_2.00		 Homo sapiens
TGMATAAWTHW
WDAWTTATKCA		 SELEX
Jolma et al.(2013)
POU3F4_2		 (Direct) (Direct)
POU3F4
M05492_2.00		 Homo sapiens
NYWYGCATAATB
VATTATGCRWRN		 SELEX
Yin et al.(2017)
POU3F4_eDBD_HT-SELEX_1		 (Direct) (Direct)
POU3F4
M05493_2.00		 Homo sapiens
NTAATGABATGCRN
NYGCATVTCATTAN		 SELEX
Yin et al.(2017)
POU3F4_eDBD_HT-SELEX_2		 (Direct) (Direct)
POU3F4
M05494_2.00		 Homo sapiens
NYGCATWMATTAN
NTAATKWATGCRN		 SELEX
Yin et al.(2017)
POU3F4_eDBD_HT-SELEX_3		 (Direct) (Direct)
POU3F4
M05495_2.00		 Homo sapiens
DHATGYRCRTMD
HKAYGYRCATDH		 SELEX
Yin et al.(2017)
POU3F4_eDBD_HT-SELEX_4		 (Direct) (Direct)
POU3F4
M05496_2.00		 Homo sapiens
DTATGCWAATKRV
BYMATTWGCATAH		 SELEX
Yin et al.(2017)
POU3F4_eDBD_HT-SELEX_5		 (Direct) (Direct)
POU3F4
M05497_2.00		 Homo sapiens
HTAATGAKATGCGH
DCGCATMTCATTAD		 SELEX
Yin et al.(2017)
POU3F4_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU3F4
M05498_2.00		 Homo sapiens
DCGCATAAATTAN
NTAATTTATGCGH		 SELEX
Yin et al.(2017)
POU3F4_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
POU3F4
M05499_2.00		 Homo sapiens
DTATGCGCATAH
DTATGCGCATAH		 SELEX
Yin et al.(2017)
POU3F4_eDBD_Methyl-HT-SELEX_3		 (Direct) (Direct)
POU3F4
M05500_2.00		 Homo sapiens
WTATGCWAATKAG
CTMATTWGCATAW		 SELEX
Yin et al.(2017)
POU3F4_eDBD_Methyl-HT-SELEX_4		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Pou3f4
M00550_2.00 		Mus musculus
NWWATKHNNN
NNNDMATWWN		 PBM
Berger et al.(2008)
Pou3f4_3773 		1.000 1.000
For this family, TFs with SR scores > 0.993 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00364_2.00 POU 19 90
M00364_2.00 Homeodomain 109 165
M00365_2.00 POU 19 90
M00365_2.00 Homeodomain 109 165
M00366_2.00 POU 19 90
M00366_2.00 Homeodomain 109 165

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000362296 POU 189 260
ENSP00000362296 Homeodomain 279 335

Links

Other Homeodomain,POU family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

39 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action