ENSP00000395926-D1 (Bos grunniens)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		ENSP00000395926-D1 T238943_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU6F2
M00363_2.00 		Homo sapiens
NTAABNNN
NNNVTTAN		 PBM
Barrera et al.(2016)
POU6F2_REF 		1.000 1.000
POU6F2
M03303_2.00 		Homo sapiens
DVCTMATTAH
DTAATKAGBH		 SELEX
Jolma et al.(2013)
POU6F2_1 		1.000 1.000
POU6F2
M03304_2.00 		Homo sapiens
HTAATKAGCTMATTAD
HTAATKAGCTMATTAD		 SELEX
Jolma et al.(2013)
POU6F2_2 		1.000 1.000
POU6F2
M03305_2.00 		Homo sapiens
NNTAATKAGS
SCTMATTANN		 SELEX
Jolma et al.(2013)
POU6F2_3 		1.000 1.000
For this family, TFs with SR scores > 0.993 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000395926-D1 POU 465 515
ENSP00000395926-D1 POU 528 572
ENSP00000395926-D1 Homeodomain 594 650

Links

Other Homeodomain,POU family TFs
Other Bos grunniens TFs

41 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AB06842.1 Alternaria brassicicola AB06842.1 I 0.000
ACRE_033300 Acremonium chrysogenum ACRE_033300 I 0.000
asl-1 Neurospora crassa NCU01345 D 0.000
ATEG_01978 Aspergillus terreus CADATEAG00007399 I 0.000
AUEXF2481DRAFT_414412 Aureobasidium subglaciale AUEXF2481DRAFT_414412 I 0.000
BAUCODRAFT_49676 Baudoinia compniacensis BAUCODRAFT_49676 I 0.000
BBA_04813 Beauveria bassiana BBA_04813 I 0.000
BDDG_06376 Blastomyces dermatitidis BDDG_06376 I 0.000
BGHDH14_bgh04237 Blumeria graminis BGHDH14_bgh04237 I 0.000
CADANGAG00011562 Aspergillus niger CADANGAG00011562 N 0.000
CANTEDRAFT_114387 Candida tenuis CANTEDRAFT_114387 I 0.000
CCM_09124 Cordyceps militaris CCM_09124 I 0.000
CCM_09413 Cordyceps militaris CCM_09413 I 0.000
CFIO01_09097 Colletotrichum fioriniae CFIO01_09097 I 0.000
CFIO01_09498 Colletotrichum fioriniae CFIO01_09498 I 0.000
CGGC5_15082 Colletotrichum gloeosporioides CGGC5_15082 I 0.000
CGGC5_3848 Colletotrichum gloeosporioides CGGC5_3848 I 0.000
CH063_00485 Colletotrichum higginsianum CH063_00485 I 0.000
CH063_08162 Colletotrichum higginsianum CH063_08162 I 0.000
CHGG_00632 Chaetomium globosum CHGG_00632 I 0.000
CIMG_03698 Coccidioides immitis CIMG_03698 I 0.000
CMQ_683 Grosmannia clavigera CMQ_683 I 0.000
Cob_09143 Colletotrichum orbiculare Cob_09143 I 0.000
Cob_09423 Colletotrichum orbiculare Cob_09423 I 0.000
COCC4DRAFT_39469 Bipolaris maydis COCC4DRAFT_39469 I 0.000
COCCADRAFT_110849 Bipolaris zeicola COCCADRAFT_110849 I 0.000
COCMIDRAFT_100301 Bipolaris oryzae COCMIDRAFT_100301 I 0.000
COCSADRAFT_216676 Bipolaris sorokiniana COCSADRAFT_216676 I 0.000
COCVIDRAFT_84814 Bipolaris victoriae COCVIDRAFT_84814 I 0.000
CPUR_07883 Claviceps purpurea CPUR_07883 I 0.000
CSUB01_02787 Colletotrichum sublineola CSUB01_02787 I 0.000
CSUB01_03969 Colletotrichum sublineola CSUB01_03969 I 0.000
CTHT_0028870 Chaetomium thermophilum CTHT_0028870 I 0.000
CTHT_0051900 Chaetomium thermophilum CTHT_0051900 I 0.000
DOTSEDRAFT_70140 Dothistroma septosporum DOTSEDRAFT_70140 I 0.000
EPUS_07920 Endocarpon pusillum EPUS_07920 I 0.000
estExt_fgenesh1_pg.C_130141 Mycosphaerella fijiensis estExt_fgenesh1_pg.C_130141 I 0.000
estExt_fgenesh1_pg.C_150146 Cochliobolus heterostrophus C5 estExt_fgenesh1_pg.C_150146 I 0.000
estExt_fgenesh1_pm.C_chr_10233 Mycosphaerella graminicola estExt_fgenesh1_pm.C_chr_10233 I 0.000
estExt_fgenesh2_pg.C_10593 Neurospora discreta estExt_fgenesh2_pg.C_10593 I 0.000
estExt_fgeneshMC_pg.C_50959 Mucor circinelloides estExt_fgeneshMC_pg.C_50959 I 0.000
estExt_fgeneshPB_pg.C_340044 Phycomyces blakesleeanus estExt_fgeneshPB_pg.C_340044 I 0.000
estExt_Genewise1.C_71204 Cryphonectria parasitica estExt_Genewise1.C_71204 I 0.000
EV44_g5736 Erysiphe necator EV44_g5736 I 0.000
FFUJ_07310 Fusarium fujikuroi FFUJ_07310 I 0.000
fgenesh1_pg.C_chr_6.1000184 Pichia stipitis fgenesh1_pg.C_chr_6.1000184 I 0.000
fgeneshMC_pg.13_#_37 Mucor circinelloides fgeneshMC_pg.13_#_37 I 0.000
fgeneshMC_pg.6_#_568 Mucor circinelloides fgeneshMC_pg.6_#_568 I 0.000
FGRRES_10142 Fusarium graminearum FGRRES_10142 I 0.000
FOXG_05265 Fusarium oxysporum FOXG_05265 I 0.000
FPSE_02636 Fusarium pseudograminearum FPSE_02636 I 0.000
FPSE_07098 Fusarium pseudograminearum FPSE_07098 N 0.000
FVEG_02866 Fusarium verticillioides FVEG_02866 I 0.000
GGTG_00729 Gaeumannomyces graminis GGTG_00729 I 0.000
GLRG_04311 Colletotrichum graminicola GLRG_04311 I 0.000
GLRG_05013 Colletotrichum graminicola GLRG_05013 I 0.000
GNLVRS01_PISO0A10934g Millerozyma farinosa GNLVRS01_PISO0A10934g I 0.000
GNLVRS01_PISO0B11001g Millerozyma farinosa GNLVRS01_PISO0B11001g I 0.000
GSTUM_00002889001 Tuber melanosporum GSTUM_00002889001 I 0.000
HCBG_06790 Histoplasma capsulatum HCBG_06790 I 0.000
HMPREF1624_04302 Sporothrix schenckii HMPREF1624_04302 I 0.000
LEMA_P001490.1 Leptosphaeria maculans LEMA_P001490.1 I 0.000
M437DRAFT_75856 Aureobasidium melanogenum M437DRAFT_75856 I 0.000
M438DRAFT_184342 Aureobasidium pullulans M438DRAFT_184342 I 0.000
MAC_03244 Metarhizium acridum MAC_03244 I 0.000
MAC_08741 Metarhizium acridum MAC_08741 I 0.000
MAJ_05238 Metarhizium majus MAJ_05238 I 0.000
MAM_05099 Metarhizium album MAM_05099 I 0.000
MAM_08111 Metarhizium album MAM_08111 N 0.000
MAM_08422 Metarhizium album MAM_08422 I 0.000
MANI_006838 Metarhizium anisopliae MANI_006838 I 0.000
MANI_025588 Metarhizium anisopliae MANI_025588 I 0.000
MAPG_05500 Magnaporthe poae MAPG_05500 I 0.000
MBM_07911 Marssonina brunnea MBM_07911 I 0.000
MBR_04061 Metarhizium brunneum MBR_04061 I 0.000
MBR_04276 Metarhizium brunneum MBR_04276 I 0.000
MBR_09777 Metarhizium brunneum MBR_09777 I 0.000
MGG_02006 Magnaporthe oryzae MGG_02006 N 0.000
MGG_08212 Magnaporthe oryzae MGG_08212 I 0.000
MGU_04987 Metarhizium guizhouense MGU_04987 I 0.000
MGU_06592 Metarhizium guizhouense MGU_06592 I 0.000
MGU_08649 Metarhizium guizhouense MGU_08649 I 0.000
MPH_06322 Macrophomina phaseolina MPH_06322 I 0.000
MPH_13454 Macrophomina phaseolina MPH_13454 I 0.000
MYCFIDRAFT_97819 Pseudocercospora fijiensis MYCFIDRAFT_97819 I 0.000
Mycgr3G98304 Zymoseptoria tritici Mycgr3G98304 I 0.000
MYCTH_2301171 Myceliophthora thermophila MYCTH_2301171 I 0.000
NEUTE1DRAFT_57442 Neurospora tetrasperma NEUTE1DRAFT_57442 I 0.000
PAAG_01945 Paracoccidioides sp lutzii PAAG_01945 I 0.000
PABG_02218 Paracoccidioides brasiliensis PABG_02218 I 0.000
PFICI_13363 Pestalotiopsis fici PFICI_13363 I 0.000
PICST_32703 Scheffersomyces stipitis PICST_32703 I 0.000
PODANS_2_1280 Podospora anserina PODANS_2_1280 I 0.000
PTT_11563 Pyrenophora teres PTT_11563 I 0.000
PV09_06343 Verruconis gallopava PV09_06343 I 0.000
RO3G_01772 Rhizopus oryzae RO3G_01772 I 0.000
RO3G_06379 Rhizopus oryzae RO3G_06379 I 0.000
RO3G_06463 Rhizopus oryzae RO3G_06463 N 0.000
RO3G_07073 Rhizopus oryzae RO3G_07073 I 0.000
RO3G_07557 Rhizopus oryzae RO3G_07557 I 0.000
RO3G_12109 Rhizopus oryzae RO3G_12109 I 0.000
S40285_01279 Stachybotrys chlorohalonata S40285_01279 I 0.000
S40285_05885 Stachybotrys chlorohalonata S40285_05885 I 0.000
S40285_09291 Stachybotrys chlorohalonata S40285_09291 I 0.000
S40285_09500 Stachybotrys chlorohalonata S40285_09500 I 0.000
S40285_09586 Stachybotrys chlorohalonata S40285_09586 I 0.000
S40288_09027 Stachybotrys chartarum S40288_09027 I 0.000
S40288_09816 Stachybotrys chartarum S40288_09816 I 0.000
SAPIO_CDS10626 Scedosporium apiospermum SAPIO_CDS10626 I 0.000
SAPIO_CDS8346 Scedosporium apiospermum SAPIO_CDS8346 I 0.000
SEPMUDRAFT_147966 Sphaerulina musiva SEPMUDRAFT_147966 I 0.000
SETTUDRAFT_28157 Setosphaeria turcica SETTUDRAFT_28157 I 0.000
SMAC_04034 Sordaria macrospora SMAC_04034 I 0.000
SNOG_05677 Stagonospora nodorum SNOG_05677 I 0.000
SNOG_05677 Phaeosphaeria nodorum SNOG_05677 I 0.000
SPBR_05727 Sporothrix brasiliensis SPBR_05727 I 0.000
THITE_2106467 Thielavia terrestris THITE_2106467 I 0.000
TRIATDRAFT_302381 Trichoderma atroviride TRIATDRAFT_302381 I 0.000
TRIATDRAFT_39837 Trichoderma atroviride TRIATDRAFT_39837 I 0.000
TRIREDRAFT_103372 Trichoderma reesei TRIREDRAFT_103372 I 0.000
TRIVIDRAFT_229017 Trichoderma virens TRIVIDRAFT_229017 I 0.000
TRIVIDRAFT_81080 Trichoderma virens TRIVIDRAFT_81080 I 0.000
UCREL1_7956 Eutypa lata UCREL1_7956 I 0.000
UCRPA7_4570 Togninia minima UCRPA7_4570 I 0.000
UREG_07457 Uncinocarpus reesii UREG_07457 I 0.000
UV8b_5734 Ustilaginoidea virens UV8b_5734 I 0.000
UV8b_87 Ustilaginoidea virens UV8b_87 I 0.000
VDAG_08676 Verticillium dahliae VDAG_08676 I 0.000
W97_02473 Coniosporium apollinis W97_02473 I 0.000
X797_004353 Metarhizium robertsii X797_004353 I 0.000
X797_004573 Metarhizium robertsii X797_004573 I 0.000
X797_010774 Metarhizium robertsii X797_010774 I 0.000
YALI0_C16863g Yarrowia lipolytica YALI0_C16863g I 0.000