HSF4 (Homo sapiens)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00447 (HSF_DNA-bind) IPR000232 ENSG00000102878 T240223_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HSF4
M03325_2.00
Homo sapiens
GAANNTTCBVGAA

TTCBVGAANNTTC
SELEX
Jolma et al.(2013)
HSF4_1
(Direct) (Direct)
HSF4
M05509_2.00
Homo sapiens
VGAABVTTCKVGAAN

NTTCBMGAABVTTCB
SELEX
Yin et al.(2017)
HSF4_eDBD_HT-SELEX
(Direct) (Direct)
HSF4
M05510_2.00
Homo sapiens
RGAABVWDCYRGAWN

NWTCYRGHWBVTTCY
SELEX
Yin et al.(2017)
HSF4_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
HSF4
M10862_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF4_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HSF1
M03329_2.00
Homo sapiens
GAANVTTCBVGAA

TTCBVGAABNTTC
SELEX
Jolma et al.(2013)
HSF1_1
0.384 0.763
HSF1
M03330_2.00
Homo sapiens
GAANRTTCBAGAA

TTCTVGAAYNTTC
SELEX
Jolma et al.(2013)
HSF1_2
0.384 0.763
HSF1
M05523_2.00
Homo sapiens
VGAABVTTCBVGAWN

NWTCBVGAABVTTCB
SELEX
Yin et al.(2017)
HSF1_eDBD_HT-SELEX
0.384 0.763
HSF1
M05525_2.00
Homo sapiens
VGAANRTTCKVGAAN

NTTCBMGAAYNTTCB
SELEX
Yin et al.(2017)
HSF1_FL_HT-SELEX
0.384 0.763
HSF1
M07977_2.00
Homo sapiens
GDCSYGGGTTCRADYCCC

GGGRHTYGAACCCRSGHC
ChIP-seq
Gerstein et al.(2012)
HepG2_HSF1_Stanford
0.384 0.763
HSF1
M09230_2.00
Homo sapiens
NRGAANNTTCYRGAA

TTCYRGAANNTTCYN
Misc
Kulakovskiy et al.(2013)
HSF1_HUMAN.H11MO.0.A
0.484 0.760
Hsf1
M09232_2.00
Mus musculus
NRGAANNTTCYRGAA

TTCYRGAANNTTCYN
Misc
Kulakovskiy et al.(2013)
HSF1_MOUSE.H11MO.0.A
0.384 0.763
HSF1
M09592_2.00
Homo sapiens
NNBBCYRGAANNTTCYRGVV

BBCYRGAANNTTCYRGVVNN
Misc
Heinz et al.(2010)
HepG2-HSF1_GSE31477
0.384 0.763
Hsf1
M09593_2.00
Mus musculus
NRGAANNTTCYRGAA

TTCYRGAANNTTCYN
Misc
Heinz et al.(2010)
Striatum-HSF1_GSE38000
0.384 0.763
HSF1
M10863_2.00
Homo sapiens
NGAAHNTTCY

RGAANDTTCN
Transfac
Matys et al.(2006)
V$HSF1_01
0.384 0.763
HSF1
M10864_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q5_01
0.384 0.763
HSF1
M10865_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q5
0.384 0.763
HSF1
M10866_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q6_01
0.384 0.763
HSF1
M10867_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q6
0.484 0.760
HSF1
M10868_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF_Q6
0.384 0.763
HSF1
M05524_2.00
Homo sapiens
RGAANRTTCYRGAWN

NWTCYRGAAYNTTCY
SELEX
Yin et al.(2017)
HSF1_eDBD_Methyl-HT-SELEX
0.384 0.763
HSF1
M05526_2.00
Homo sapiens
RGAANVTTCYRGAWN

NWTCYRGAABNTTCY
SELEX
Yin et al.(2017)
HSF1_FL_Methyl-HT-SELEX
0.384 0.763
Hsf2
M09231_2.00
Mus musculus
VGAABVTTCKVGAN

NTCBMGAABVTTCB
Misc
Kulakovskiy et al.(2013)
HSF2_MOUSE.H11MO.0.A
0.379 0.625
HSF2
M03324_2.00
Homo sapiens
GAANVTTCTAGAA

TTCTAGAABNTTC
SELEX
Jolma et al.(2013)
HSF2_1
0.372 0.615
HSF2
M02744_2.00
Homo sapiens
GAABGTTCTRGA

TCYAGAACVTTC
SELEX
Jolma et al.(2010)
HSF2_dimertrimer
0.372 0.615
HSF2
M05505_2.00
Homo sapiens
VGAABVTTCBVGAWN

NWTCBVGAABVTTCB
SELEX
Yin et al.(2017)
HSF2_eDBD_HT-SELEX
0.372 0.615
HSF2
M05507_2.00
Homo sapiens
VGAANNTTCBVGAAN

NTTCBVGAANNTTCB
SELEX
Yin et al.(2017)
HSF2_FL_HT-SELEX
0.372 0.615
HSF2
M09229_2.00
Homo sapiens
VGAABVTTCKVGAN

NTCBMGAABVTTCB
Misc
Kulakovskiy et al.(2013)
HSF2_HUMAN.H11MO.0.A
0.372 0.615
HSF2
M10859_2.00
Homo sapiens
VGAANNWTCB

VGAWNNTTCB
Transfac
Matys et al.(2006)
V$HSF2_01
0.372 0.615
HSF2
M10860_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF2_02
0.372 0.615
HSF2
M10861_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF2_Q6
0.372 0.615
HSF2
M05506_2.00
Homo sapiens
RGAABVTTCYRGAWN

NWTCYRGAABVTTCY
SELEX
Yin et al.(2017)
HSF2_eDBD_Methyl-HT-SELEX
0.372 0.615
HSF2
M05508_2.00
Homo sapiens
RGAABVTTCYRGAWN

NWTCYRGAABVTTCY
SELEX
Yin et al.(2017)
HSF2_FL_Methyl-HT-SELEX
0.372 0.615
hsf2
M02248_2.00
Danio rerio
NNNWGTTCTATNN

NNATAGAACWNNN
PBM
Weirauch et al.(2014)
pTH9010
0.361 0.604
HSF1
M00060_2.00
Saccharomyces cerevisiae
NNNTTCNNN

NNNGAANNN
PBM
Badis et al.(2008)
HSF1_4530
0.342 0.469
HSF1
M07489_2.00
Saccharomyces cerevisiae
HVTTCCAT

ATGGAABD
PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0319.1
0.342 0.469
HSF1
M08577_2.00
Saccharomyces cerevisiae
TTCTAGAA

TTCTAGAA
Misc
DeBoer et al.(2011)
YGL073W_1461
0.342 0.469
HSF1
M08578_2.00
Saccharomyces cerevisiae
GAANNNNNWRGAA

TTCYWNNNNNTTC
Misc
DeBoer et al.(2011)
YGL073W_411
0.342 0.469
HSF1
M08579_2.00
Saccharomyces cerevisiae
HVTTCCAT

ATGGAABD
Misc
DeBoer et al.(2011)
YGL073W_476
0.342 0.469
HSF1
M08580_2.00
Saccharomyces cerevisiae
RGAABNTTCTRGAA

TTCYAGAANVTTCY
Misc
DeBoer et al.(2011)
YGL073W_615
0.342 0.469
HSF1
M10874_2.00
Saccharomyces cerevisiae
RGAANRGAANRGAAN

NTTCYNTTCYNTTCY
Transfac
Matys et al.(2006)
F$HSF_02
0.342 0.469
HSF1
M10875_2.00
Saccharomyces cerevisiae
RGAANNTTCYNTTCY

RGAANRGAANNTTCY
Transfac
Matys et al.(2006)
F$HSF_03
0.342 0.469
HSF1
M10876_2.00
Saccharomyces cerevisiae
RGAANNTTCYRGAAN

NTTCYRGAANNTTCY
Transfac
Matys et al.(2006)
F$HSF_04
0.342 0.469
HSF1
M10877_2.00
Saccharomyces cerevisiae
NTTCYNTTCYRGAAN

NTTCYRGAANRGAAN
Transfac
Matys et al.(2006)
F$HSF_05
0.342 0.469
HSF1
M10878_2.00
Saccharomyces cerevisiae Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
F$HSF_Q6
0.342 0.469
hsf-1
M02249_2.00
Neurospora crassa
NNNTTCBDNN

NNHVGAANNN
PBM
Weirauch et al.(2014)
pTH8857
0.327 0.448
ANIA_08035
M02247_2.00
Aspergillus nidulans
NNNNTTCYRN

NYRGAANNNN
PBM
Weirauch et al.(2014)
pTH8231
0.325 0.448
hsf-1
M00682_2.00
Caenorhabditis elegans
TTCYAGAA

TTCTRGAA
PBM
Narasimhan et al.(2015)
pTH10796
0.322 0.521
For this family, TFs with SR scores > 0.318 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000264009 HSF 20 121
ENSP00000403219 HSF 20 121
ENSP00000427832 HSF 20 121
ENSP00000428161 HSF 20 121
ENSP00000428978 HSF 20 121
ENSP00000430299 HSF 1 79
ENSP00000430631 HSF 20 121
ENSP00000430947 HSF 20 121
ENSP00000463706 HSF 20 121

Links

Other HSF family TFs
Other Homo sapiens TFs

629 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
28428.m000040 Ricinus communis 28428.m000040 I 0.000
Aquca_017_00693 Aquilegia coerulea Aquca_017_00693 I 0.000
Aquca_034_00400 Aquilegia coerulea Aquca_034_00400 I 0.000
BGIOSGA005344 Oryza indica BGIOSGA005344 I 0.000
BGIOSGA011445 Oryza indica BGIOSGA011445 I 0.000
BGIOSGA026473 Oryza indica BGIOSGA026473 I 0.000
Bo4g016000 Brassica oleracea Bo4g016000 I 0.000
Bo4g108600 Brassica oleracea Bo4g108600 I 0.000
Bo4g191530 Brassica oleracea Bo4g191530 I 0.000
Bo4g191540 Brassica oleracea Bo4g191540 N 0.000
Bo8g092560 Brassica oleracea Bo8g092560 I 0.000
Bostr.20903s0070 Boechera stricta Bostr.20903s0070 I 0.000
Bostr.24513s0089 Boechera stricta Bostr.24513s0089 N 0.000
Bostr.25993s0538 Boechera stricta Bostr.25993s0538 I 0.000
Bra004693 Brassica rapa Bra004693 I 0.000
Bra007385 Brassica rapa Bra007385 N 0.000
Bra014581 Brassica rapa Bra014581 I 0.000
Bra016876 Brassica rapa Bra016876 N 0.000
Bra018260 Brassica rapa Bra018260 N 0.000
Bra021737 Brassica rapa Bra021737 N 0.000
BRADI3G12550 Brachypodium distachyon BRADI3G12550 I 0.000
Cagra.0686s0036 Capsella grandiflora Cagra.0686s0036 I 0.000
Cagra.6952s0010 Capsella grandiflora Cagra.6952s0010 N 0.000
Carubv10019250m.g Capsella rubella Carubv10019250m.g I 0.000
Carubv10025067m.g Capsella rubella Carubv10025067m.g N 0.000
cassava40664.m1 Manihot esculenta cassava40664.m1 I 0.000
cassava41632.m1 Manihot esculenta cassava41632.m1 I 0.000
Ca_07763 Cicer arietinum Ca_07763 I 0.000
Ca_12214 Cicer arietinum Ca_12214 I 0.000
Ciclev10023341m.g Citrus clementina Ciclev10023341m.g I 0.000
Cla006087 Citrullus lanatus Cla006087 I 0.000
Cla015094 Citrullus lanatus Cla015094 I 0.000
Cucsa.053450 Cucumis sativus Cucsa.053450 I 0.000
Cucsa.388160 Cucumis sativus Cucsa.388160 I 0.000
Eucgr.B01529 Eucalyptus grandis Eucgr.B01529 I 0.000
evm.TU.supercontig_50.42 Carica papaya evm.TU.supercontig_50.42 I 0.000
F775_02052 Aegilops tauschii F775_02052 I 0.000
gene08253-v1.0-hybrid Fragaria vesca gene08253-v1.0-hybrid I 0.000
GLYMA03G31860 Glycine max GLYMA03G31860 I 0.000
GLYMA10G04050 Glycine max GLYMA10G04050 I 0.000
GLYMA13G18210 Glycine max GLYMA13G18210 I 0.000
GLYMA19G34600 Glycine max GLYMA19G34600 I 0.000
Gorai.001G251700 Gossypium raimondii Gorai.001G251700 I 0.000
Gorai.004G073300 Gossypium raimondii Gorai.004G073300 I 0.000
Gorai.004G220000 Gossypium raimondii Gorai.004G220000 I 0.000
Gorai.007G144500 Gossypium raimondii Gorai.007G144500 I 0.000
GRMZM2G075499 Zea mays GRMZM2G075499 I 0.000
GRMZM2G092542 Zea mays GRMZM2G092542 I 0.000
GSMUA_Achr10G06700_001 Musa acuminata GSMUA_Achr10G06700_001 I 0.000
GSMUA_Achr1G01360_001 Musa acuminata GSMUA_Achr1G01360_001 I 0.000
GSMUA_Achr1G06580_001 Musa acuminata GSMUA_Achr1G06580_001 I 0.000
GSMUA_Achr4G25190_001 Musa acuminata GSMUA_Achr4G25190_001 I 0.000
GSMUA_Achr8G14330_001 Musa acuminata GSMUA_Achr8G14330_001 I 0.000
GSMUA_AchrUn_randomG07730_001 Musa acuminata GSMUA_AchrUn_randomG07730_001 I 0.000
GSMUA_AchrUn_randomG23710_001 Musa acuminata GSMUA_AchrUn_randomG23710_001 I 0.000
LBD14 Arabidopsis thaliana AT2G31310 N 0.000
LBD14 Arabidopsis lyrata fgenesh1_pg.C_scaffold_4001244 N 0.000
LBD29 Arabidopsis thaliana AT3G58190 I 0.000
LBD29 Arabidopsis lyrata fgenesh2_kg.5__2263__AT3G58190.1 I 0.000
LjT35F15.90.nd Lotus japonicus LjT35F15.90.nd I 0.000
LPERR02G31040 Leersia perrieri LPERR02G31040 I 0.000
LPERR03G03470 Leersia perrieri LPERR03G03470 I 0.000
LPERR08G20530 Leersia perrieri LPERR08G20530 I 0.000
Lus10000613.g Linum usitatissimum Lus10000613.g I 0.000
Lus10033873.g Linum usitatissimum Lus10033873.g I 0.000
mgf020773m Mimulus guttatus mgf020773m I 0.000
MLOC_52276 Hordeum vulgare MLOC_52276 I 0.000
MLOC_61947 Hordeum vulgare MLOC_61947 I 0.000
MTR_1g070205 Medicago truncatula MTR_1g070205 I 0.000
MTR_7g096610 Medicago truncatula MTR_7g096610 I 0.000
OB02G44330 Oryza brachyantha OB02G44330 I 0.000
OB03G13890 Oryza brachyantha OB03G13890 I 0.000
OB08G30680 Oryza brachyantha OB08G30680 I 0.000
OBART03G03830 Oryza barthii OBART03G03830 I 0.000
OBART08G23860 Oryza barthii OBART08G23860 I 0.000
OGLUM02G38740 Oryza glumaepatula OGLUM02G38740 I 0.000
OGLUM08G25340 Oryza glumaepatula OGLUM08G25340 I 0.000
OLONG_010223 Oryza longistaminata OLONG_010223 I 0.000
OMERI02G35350 Oryza meridionalis OMERI02G35350 I 0.000
OMERI07G01660 Oryza meridionalis OMERI07G01660 I 0.000
OMERI08G18670 Oryza meridionalis OMERI08G18670 I 0.000
ONIVA02G40360 Oryza nivara ONIVA02G40360 I 0.000
ONIVA03G03580 Oryza nivara ONIVA03G03580 I 0.000
ONIVA09G01330 Oryza nivara ONIVA09G01330 I 0.000
OPUNC02G34750 Oryza punctata OPUNC02G34750 I 0.000
OPUNC03G03520 Oryza punctata OPUNC03G03520 I 0.000
OPUNC08G21770 Oryza punctata OPUNC08G21770 I 0.000
orange1.1g027399m.g Citrus sinensis orange1.1g027399m.g I 0.000
ORGLA02G0327800 Oryza glaberrima ORGLA02G0327800 I 0.000
ORGLA03G0035900 Oryza glaberrima ORGLA03G0035900 I 0.000
ORGLA08G0192400 Oryza glaberrima ORGLA08G0192400 I 0.000
ORUFI02G39110 Oryza rufipogon ORUFI02G39110 I 0.000
ORUFI03G03550 Oryza rufipogon ORUFI03G03550 I 0.000
ORUFI08G26340 Oryza rufipogon ORUFI08G26340 I 0.000
OS02G0820500 Oryza sativa OS02G0820500 I 0.000
OS03G0149100 Oryza sativa OS03G0149100 I 0.000
OS08G0563400 Oryza sativa OS08G0563400 I 0.000
Pavir.Aa00097 Panicum virgatum Pavir.Aa00097 I 0.000
Pavir.Fa00011 Panicum virgatum Pavir.Fa00011 I 0.000
Pavir.Ia04220 Panicum virgatum Pavir.Ia04220 I 0.000
Pavir.Ib00283 Panicum virgatum Pavir.Ib00283 I 0.000
Pavir.J39638 Panicum virgatum Pavir.J39638 I 0.000
PGSC0003DMG400009716 Solanum tuberosum PGSC0003DMG400009716 I 0.000
PK23380.1 Cannabis sativa PK23380.1 I 0.000
Pm020627 Prunus mume Pm020627 I 0.000
Pm020628 Prunus mume Pm020628 I 0.000
POPTR_0002s04200 Populus trichocarpa POPTR_0002s04200 I 0.000
PRUPE_ppa019939mg Prunus persica PRUPE_ppa019939mg I 0.000
PRUPE_ppa025889mg Prunus persica PRUPE_ppa025889mg I 0.000
SapurV1A.0006s0970 Salix purpurea SapurV1A.0006s0970 I 0.000
Sb01g046990 Sorghum bicolor Sb01g046990 I 0.000
Sb04g037550 Sorghum bicolor Sb04g037550 I 0.000
Sb07g023810 Sorghum bicolor Sb07g023810 I 0.000
Si015156m.g Setaria italica Si015156m.g I 0.000
Si040019m.g Setaria italica Si040019m.g I 0.000
Solyc09g066270.2 Solanum lycopersicum Solyc09g066270.2 I 0.000
TCM_004103 Theobroma cacao TCM_004103 I 0.000
Thhalv10006226m.g Eutrema salsugineum Thhalv10006226m.g I 0.000
Thhalv10017158m.g Eutrema salsugineum Thhalv10017158m.g I 0.000
Thhalv10017299m.g Eutrema salsugineum Thhalv10017299m.g N 0.000
Thhalv10017903m.g Eutrema salsugineum Thhalv10017903m.g N 0.000
Traes_4BS_5D9291539 Triticum aestivum Traes_4BS_5D9291539 I 0.000
Traes_6BS_179B5B6E1 Triticum aestivum Traes_6BS_179B5B6E1 I 0.000
VIT_07s0005g03020 Vitis vinifera VIT_07s0005g03020 I 0.000