HSFY1 (Homo sapiens)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00447 (HSF_DNA-bind) IPR000232 ENSG00000172468 T240226_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HSFY1
M05515_2.00		 Homo sapiens
NDTVGAAYGWTTCGAAYGB
VCRTTCGAAWCRTTCBAHN		 SELEX
Yin et al.(2017)
HSFY1_eDBD_HT-SELEX_1		 (Direct) (Direct)
HSFY1
M05516_2.00		 Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY1_eDBD_HT-SELEX_2		 (Direct) (Direct)
HSFY1
M05517_2.00		 Homo sapiens
NDTRGAATGTTTRGAATGB
VCATTCYAAACATTCYAHN		 SELEX
Yin et al.(2017)
HSFY1_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
HSFY1
M05518_2.00		 Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY1_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HSFY2
M03326_2.00 		Homo sapiens
WTCGAWNVRWTCGAW
WTCGAWYBNWTCGAW		 SELEX
Jolma et al.(2013)
HSFY2_1 		0.647 1.000
HSFY2
M03327_2.00 		Homo sapiens
CRTTCGAWW
WWTCGAAYG		 SELEX
Jolma et al.(2013)
HSFY2_2 		0.517 0.788
HSFY2
M03328_2.00 		Homo sapiens
DTCGAAHSNWTCGAW
WTCGAWNSDTTCGAH		 SELEX
Jolma et al.(2013)
HSFY2_3 		0.517 0.788
HSFY2
M05511_2.00 		Homo sapiens
NDTVGAAYGWTTCGAAYGB
VCRTTCGAAWCRTTCBAHN		 SELEX
Yin et al.(2017)
HSFY2_eDBD_HT-SELEX_1 		0.517 0.788
HSFY2
M05512_2.00 		Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY2_eDBD_HT-SELEX_2 		0.491 0.717
HSFY2
M05513_2.00 		Homo sapiens
NDWRGAAYGTTTRGAAYGB
VCRTTCYAAACRTTCYWHN		 SELEX
Yin et al.(2017)
HSFY2_eDBD_Methyl-HT-SELEX_1 		0.517 0.788
HSFY2
M05514_2.00 		Homo sapiens
DTTCGAAHSDTTCGAAH
DTTCGAAHSDTTCGAAH		 SELEX
Yin et al.(2017)
HSFY2_eDBD_Methyl-HT-SELEX_2 		0.517 0.788
HSF5
M05519_2.00 		Homo sapiens
NRCRTTCTAGAACGYN
NRCGTTCTAGAAYGYN		 SELEX
Yin et al.(2017)
HSF5_eDBD_HT-SELEX_1 		0.323 0.432
HSF5
M05520_2.00 		Homo sapiens
YVGAAYRYNNNNNNNNNBHACRTTCBR
YVGAAYGTDVNNNNNNNNNRYRTTCBR		 SELEX
Yin et al.(2017)
HSF5_eDBD_HT-SELEX_2 		0.323 0.432
HSF5
M05521_2.00 		Homo sapiens
AACRTTCTAGAAYGTT
AACRTTCTAGAAYGTT		 SELEX
Yin et al.(2017)
HSF5_eDBD_Methyl-HT-SELEX_1 		0.323 0.432
HSF5
M05522_2.00 		Homo sapiens
YRGAAYDYNVNNNNNNNBAACRTTCYR
YRGAAYGTTVNNNNNNNBNRHRTTCYR		 SELEX
Yin et al.(2017)
HSF5_eDBD_Methyl-HT-SELEX_2 		0.323 0.432
For this family, TFs with SR scores > 0.318 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000303599 HSF 80 195
ENSP00000311166 HSF 80 183
ENSP00000342302 HSF 80 193
ENSP00000372307 HSF 80 193

Links

Other HSF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

139 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action