TF Information

HSF1 *(Homo sapiens)* HSF
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00447 (HSF_DNA-bind)	IPR000232	ENSG00000185122	T240228_2.00	Ensembl (2018-Dec-8)	Link out
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
HSF1 M03329_2.00	Homo sapiens	GAANVTTCBVGAA	TTCBVGAABNTTC	SELEX Jolma et al.(2013) HSF1_1	(Direct)	(Direct)
HSF1 M03330_2.00	Homo sapiens	GAANRTTCBAGAA	TTCTVGAAYNTTC	SELEX Jolma et al.(2013) HSF1_2	(Direct)	(Direct)
HSF1 M05523_2.00	Homo sapiens	VGAABVTTCBVGAWN	NWTCBVGAABVTTCB	SELEX Yin et al.(2017) HSF1_eDBD_HT-SELEX	(Direct)	(Direct)
HSF1 M05524_2.00	Homo sapiens	RGAANRTTCYRGAWN	NWTCYRGAAYNTTCY	SELEX Yin et al.(2017) HSF1_eDBD_Methyl-HT-SELEX	(Direct)	(Direct)
HSF1 M05525_2.00	Homo sapiens	VGAANRTTCKVGAAN	NTTCBMGAAYNTTCB	SELEX Yin et al.(2017) HSF1_FL_HT-SELEX	(Direct)	(Direct)
HSF1 M05526_2.00	Homo sapiens	RGAANVTTCYRGAWN	NWTCYRGAABNTTCY	SELEX Yin et al.(2017) HSF1_FL_Methyl-HT-SELEX	(Direct)	(Direct)
HSF1 M07977_2.00	Homo sapiens	GDCSYGGGTTCRADYCCC	GGGRHTYGAACCCRSGHC	ChIP-seq Gerstein et al.(2012) HepG2_HSF1_Stanford	(Direct)	(Direct)
HSF1 M09230_2.00	Homo sapiens	NRGAANNTTCYRGAA	TTCYRGAANNTTCYN	Misc Kulakovskiy et al.(2013) HSF1_HUMAN.H11MO.0.A	(Direct)	(Direct)
HSF1 M09592_2.00	Homo sapiens	NNBBCYRGAANNTTCYRGVV	BBCYRGAANNTTCYRGVVNN	Misc Heinz et al.(2010) HepG2-HSF1_GSE31477	(Direct)	(Direct)
HSF1 M10863_2.00	Homo sapiens	NGAAHNTTCY	RGAANDTTCN	Transfac Matys et al.(2006) V$HSF1_01	(Direct)	(Direct)
HSF1 M10864_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF1_Q5_01	(Direct)	(Direct)
HSF1 M10865_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF1_Q5	(Direct)	(Direct)
HSF1 M10866_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF1_Q6_01	(Direct)	(Direct)
HSF1 M10867_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF1_Q6	(Direct)	(Direct)
HSF1 M10868_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF_Q6	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hsf1 M09232_2.00	Mus musculus	NRGAANNTTCYRGAA	TTCYRGAANNTTCYN	Misc Kulakovskiy et al.(2013) HSF1_MOUSE.H11MO.0.A	0.670	1.000
Hsf1 M09593_2.00	Mus musculus	NRGAANNTTCYRGAA	TTCYRGAANNTTCYN	Misc Heinz et al.(2010) Striatum-HSF1_GSE38000	0.401	1.000
HSF4 M03325_2.00	Homo sapiens	GAANNTTCBVGAA	TTCBVGAANNTTC	SELEX Jolma et al.(2013) HSF4_1	0.334	0.784
HSF4 M05509_2.00	Homo sapiens	VGAABVTTCKVGAAN	NTTCBMGAABVTTCB	SELEX Yin et al.(2017) HSF4_eDBD_HT-SELEX	0.484	0.760
HSF4 M10862_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF4_Q3	0.484	0.760
HSF4 M05510_2.00	Homo sapiens	RGAABVWDCYRGAWN	NWTCYRGHWBVTTCY	SELEX Yin et al.(2017) HSF4_eDBD_Methyl-HT-SELEX	0.484	0.760
hsf2 M02248_2.00	Danio rerio	NNNWGTTCTATNN	NNATAGAACWNNN	PBM Weirauch et al.(2014) pTH9010	0.415	0.688
Hsf2 M09231_2.00	Mus musculus	VGAABVTTCKVGAN	NTCBMGAABVTTCB	Misc Kulakovskiy et al.(2013) HSF2_MOUSE.H11MO.0.A	0.408	0.677
HSF2 M03324_2.00	Homo sapiens	GAANVTTCTAGAA	TTCTAGAABNTTC	SELEX Jolma et al.(2013) HSF2_1	0.401	0.667
HSF2 M02744_2.00	Homo sapiens	GAABGTTCTRGA	TCYAGAACVTTC	SELEX Jolma et al.(2010) HSF2_dimertrimer	0.401	0.667
HSF2 M05505_2.00	Homo sapiens	VGAABVTTCBVGAWN	NWTCBVGAABVTTCB	SELEX Yin et al.(2017) HSF2_eDBD_HT-SELEX	0.401	0.667
HSF2 M05507_2.00	Homo sapiens	VGAANNTTCBVGAAN	NTTCBVGAANNTTCB	SELEX Yin et al.(2017) HSF2_FL_HT-SELEX	0.401	0.667
HSF2 M09229_2.00	Homo sapiens	VGAABVTTCKVGAN	NTCBMGAABVTTCB	Misc Kulakovskiy et al.(2013) HSF2_HUMAN.H11MO.0.A	0.401	0.667
HSF2 M10859_2.00	Homo sapiens	VGAANNWTCB	VGAWNNTTCB	Transfac Matys et al.(2006) V$HSF2_01	0.401	0.667
HSF2 M10860_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF2_02	0.401	0.667
HSF2 M10861_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HSF2_Q6	0.401	0.667
HSF2 M05506_2.00	Homo sapiens	RGAABVTTCYRGAWN	NWTCYRGAABVTTCY	SELEX Yin et al.(2017) HSF2_eDBD_Methyl-HT-SELEX	0.401	0.667
HSF2 M05508_2.00	Homo sapiens	RGAABVTTCYRGAWN	NWTCYRGAABVTTCY	SELEX Yin et al.(2017) HSF2_FL_Methyl-HT-SELEX	0.401	0.667
Hsf M03908_2.00	Drosophila melanogaster	BVGAANRTTCTVGAANN	NNTTCBAGAAYNTTCBV	SELEX Nitta et al.(2015) Hsf_1	0.358	0.562
Hsf M03909_2.00	Drosophila melanogaster	NVGAAYNTTCBAGAANN	NNTTCTVGAANRTTCBN	SELEX Nitta et al.(2015) Hsf_2	0.358	0.562
Hsf M03910_2.00	Drosophila melanogaster	NVGAAYNTTCTVGAANN	NNTTCBAGAANRTTCBN	SELEX Nitta et al.(2015) Hsf_3	0.358	0.562
Hsf M03911_2.00	Drosophila melanogaster	NVGAANRTTCBAGAANN	NNTTCTVGAAYNTTCBN	SELEX Nitta et al.(2015) Hsf_4	0.358	0.562
Hsf M06388_2.00	Drosophila melanogaster	KMGAADNTTCKMGA	TCKMGAANHTTCKM	B1H Zhu et al.(2011) Hsf_FlyReg_FBgn0001222	0.358	0.562
Hsf M10869_2.00	Drosophila melanogaster	HTTCK	MGAAD	Transfac Matys et al.(2006) I$HSF_01	0.358	0.562
Hsf M10870_2.00	Drosophila melanogaster	MGAADMGAADMGAAD	HTTCKHTTCKHTTCK	Transfac Matys et al.(2006) I$HSF_02	0.358	0.562
Hsf M10871_2.00	Drosophila melanogaster	MGAADHTTCKHTTCK	MGAADMGAADHTTCK	Transfac Matys et al.(2006) I$HSF_03	0.358	0.562
Hsf M10872_2.00	Drosophila melanogaster	MGAADHTTCKMGAAD	HTTCKMGAADHTTCK	Transfac Matys et al.(2006) I$HSF_04	0.358	0.562
Hsf M10873_2.00	Drosophila melanogaster	HTTCKHTTCKMGAAD	HTTCKMGAADMGAAD	Transfac Matys et al.(2006) I$HSF_05	0.358	0.562
HSFB2B M06945_2.00	Arabidopsis thaliana	RGAANNTTCTAGAA	TTCTAGAANNTTCY	Dap-seq OMalley et al.(2016) HSF7_col_a	0.346	0.521
HSFB2B M06946_2.00	Arabidopsis thaliana	RGAANNTTCTAGAA	TTCTAGAANNTTCY	Dap-seq OMalley et al.(2016) HSF7_colamp_a	0.346	0.521
HSFB2A M00869_2.00	Arabidopsis thaliana	NNNNNTTCB	VGAANNNNN	PBM Franco-Zorrilla et al.(2014) HSFB2A	0.328	0.500
HSFB2A M06952_2.00	Arabidopsis thaliana	GAANNTTCYAGA	TCTRGAANNTTC	Dap-seq OMalley et al.(2016) HSF6_col_a	0.328	0.500
hsf-1 M00682_2.00	Caenorhabditis elegans	TTCYAGAA	TTCTRGAA	PBM Narasimhan et al.(2015) pTH10796	0.325	0.531
hsf-1 M02249_2.00	Neurospora crassa	NNNTTCBDNN	NNHVGAANNN	PBM Weirauch et al.(2014) pTH8857	0.322	0.438
ANIA_08035 M02247_2.00	Aspergillus nidulans	NNNNTTCYRN	NYRGAANNNN	PBM Weirauch et al.(2014) pTH8231	0.322	0.448
For this family, TFs with SR scores > 0.318* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSP00000383590	HSF	18	119	FLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKV
ENSP00000431512	HSF	18	119	FLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKV
ENSP00000436616	HSF	1	54	MASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKV
ENSP00000481007	HSF	18	57	FLTKLWTLVSDPDTDALICWSPLPGSRLVYMVRPCKTGQL
ENSP00000484174	HSF	1	43	XFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKV

Links
Other HSF family TFs
Other *Homo sapiens* TFs

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674 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action

HSF1 (Homo sapiens) HSF

TF Information

Directly determined binding motifs

Motifs from related TFs

DNA Binding Domains

Links

674 Related TFs

Invalid Input OrderBy

HSF1 **(Homo sapiens)
HSF**