Hsf (Drosophila melanogaster)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00447 (HSF_DNA-bind) IPR000232 FBgn0001222 T240538_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; positive regulation of DNA binding activity; and regulation of transcription, DNA-templated. Located in chromatin; nucleus; and polytene chromosome. Is expressed in several structures, including embryonic/larval crystal cell; embryonic/larval midgut; and germ layer derivative. Human ortholog(s) of this gene implicated in Huntington's disease; cataract; and cataract 5 multiple types. Orthologous to several human genes including HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hsf
M03908_2.00		 Drosophila melanogaster
BVGAANRTTCTVGAANN
NNTTCBAGAAYNTTCBV		 SELEX
Nitta et al.(2015)
Hsf_1		 (Direct) (Direct)
Hsf
M03909_2.00		 Drosophila melanogaster
NVGAAYNTTCBAGAANN
NNTTCTVGAANRTTCBN		 SELEX
Nitta et al.(2015)
Hsf_2		 (Direct) (Direct)
Hsf
M03910_2.00		 Drosophila melanogaster
NVGAAYNTTCTVGAANN
NNTTCBAGAANRTTCBN		 SELEX
Nitta et al.(2015)
Hsf_3		 (Direct) (Direct)
Hsf
M03911_2.00		 Drosophila melanogaster
NVGAANRTTCBAGAANN
NNTTCTVGAAYNTTCBN		 SELEX
Nitta et al.(2015)
Hsf_4		 (Direct) (Direct)
Hsf
M06388_2.00		 Drosophila melanogaster
KMGAADNTTCKMGA
TCKMGAANHTTCKM		 B1H
Zhu et al.(2011)
Hsf_FlyReg_FBgn0001222		 (Direct) (Direct)
Hsf
M10869_2.00		 Drosophila melanogaster
HTTCK
MGAAD		 Transfac
Matys et al.(2006)
I$HSF_01		 (Direct) (Direct)
Hsf
M10870_2.00		 Drosophila melanogaster
MGAADMGAADMGAAD
HTTCKHTTCKHTTCK		 Transfac
Matys et al.(2006)
I$HSF_02		 (Direct) (Direct)
Hsf
M10871_2.00		 Drosophila melanogaster
MGAADHTTCKHTTCK
MGAADMGAADHTTCK		 Transfac
Matys et al.(2006)
I$HSF_03		 (Direct) (Direct)
Hsf
M10872_2.00		 Drosophila melanogaster
MGAADHTTCKMGAAD
HTTCKMGAADHTTCK		 Transfac
Matys et al.(2006)
I$HSF_04		 (Direct) (Direct)
Hsf
M10873_2.00		 Drosophila melanogaster
HTTCKHTTCKMGAAD
HTTCKMGAADMGAAD		 Transfac
Matys et al.(2006)
I$HSF_05		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HSF1
M03329_2.00 		Homo sapiens
GAANVTTCBVGAA
TTCBVGAABNTTC		 SELEX
Jolma et al.(2013)
HSF1_1 		0.358 0.562
HSF1
M03330_2.00 		Homo sapiens
GAANRTTCBAGAA
TTCTVGAAYNTTC		 SELEX
Jolma et al.(2013)
HSF1_2 		0.358 0.562
HSF1
M05523_2.00 		Homo sapiens
VGAABVTTCBVGAWN
NWTCBVGAABVTTCB		 SELEX
Yin et al.(2017)
HSF1_eDBD_HT-SELEX 		0.358 0.562
HSF1
M05525_2.00 		Homo sapiens
VGAANRTTCKVGAAN
NTTCBMGAAYNTTCB		 SELEX
Yin et al.(2017)
HSF1_FL_HT-SELEX 		0.358 0.562
HSF1
M07977_2.00 		Homo sapiens
GDCSYGGGTTCRADYCCC
GGGRHTYGAACCCRSGHC		 ChIP-seq
Gerstein et al.(2012)
HepG2_HSF1_Stanford 		0.358 0.562
HSF1
M09230_2.00 		Homo sapiens
NRGAANNTTCYRGAA
TTCYRGAANNTTCYN		 Misc
Kulakovskiy et al.(2013)
HSF1_HUMAN.H11MO.0.A 		0.358 0.562
Hsf1
M09232_2.00 		Mus musculus
NRGAANNTTCYRGAA
TTCYRGAANNTTCYN		 Misc
Kulakovskiy et al.(2013)
HSF1_MOUSE.H11MO.0.A 		0.358 0.562
HSF1
M09592_2.00 		Homo sapiens
NNBBCYRGAANNTTCYRGVV
BBCYRGAANNTTCYRGVVNN		 Misc
Heinz et al.(2010)
HepG2-HSF1_GSE31477 		0.358 0.562
Hsf1
M09593_2.00 		Mus musculus
NRGAANNTTCYRGAA
TTCYRGAANNTTCYN		 Misc
Heinz et al.(2010)
Striatum-HSF1_GSE38000 		0.358 0.562
HSF1
M10863_2.00 		Homo sapiens
NGAAHNTTCY
RGAANDTTCN		 Transfac
Matys et al.(2006)
V$HSF1_01 		0.358 0.562
HSF1
M10864_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF1_Q5_01 		0.358 0.562
HSF1
M10865_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF1_Q5 		0.358 0.562
HSF1
M10866_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF1_Q6_01 		0.358 0.562
HSF1
M10867_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF1_Q6 		0.358 0.562
HSF1
M10868_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF_Q6 		0.358 0.562
HSF1
M05524_2.00 		Homo sapiens
RGAANRTTCYRGAWN
NWTCYRGAAYNTTCY		 SELEX
Yin et al.(2017)
HSF1_eDBD_Methyl-HT-SELEX 		0.358 0.562
HSF1
M05526_2.00 		Homo sapiens
RGAANVTTCYRGAWN
NWTCYRGAABNTTCY		 SELEX
Yin et al.(2017)
HSF1_FL_Methyl-HT-SELEX 		0.358 0.562
hsf2
M02248_2.00 		Danio rerio
NNNWGTTCTATNN
NNATAGAACWNNN		 PBM
Weirauch et al.(2014)
pTH9010 		0.349 0.552
HSF2
M03324_2.00 		Homo sapiens
GAANVTTCTAGAA
TTCTAGAABNTTC		 SELEX
Jolma et al.(2013)
HSF2_1 		0.343 0.542
HSF2
M02744_2.00 		Homo sapiens
GAABGTTCTRGA
TCYAGAACVTTC		 SELEX
Jolma et al.(2010)
HSF2_dimertrimer 		0.343 0.542
HSF2
M05505_2.00 		Homo sapiens
VGAABVTTCBVGAWN
NWTCBVGAABVTTCB		 SELEX
Yin et al.(2017)
HSF2_eDBD_HT-SELEX 		0.343 0.542
HSF2
M05507_2.00 		Homo sapiens
VGAANNTTCBVGAAN
NTTCBVGAANNTTCB		 SELEX
Yin et al.(2017)
HSF2_FL_HT-SELEX 		0.343 0.542
HSF2
M09229_2.00 		Homo sapiens
VGAABVTTCKVGAN
NTCBMGAABVTTCB		 Misc
Kulakovskiy et al.(2013)
HSF2_HUMAN.H11MO.0.A 		0.343 0.542
HSF2
M10859_2.00 		Homo sapiens
VGAANNWTCB
VGAWNNTTCB		 Transfac
Matys et al.(2006)
V$HSF2_01 		0.343 0.542
HSF2
M10860_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF2_02 		0.343 0.542
HSF2
M10861_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HSF2_Q6 		0.343 0.542
HSF2
M05506_2.00 		Homo sapiens
RGAABVTTCYRGAWN
NWTCYRGAABVTTCY		 SELEX
Yin et al.(2017)
HSF2_eDBD_Methyl-HT-SELEX 		0.343 0.542
HSF2
M05508_2.00 		Homo sapiens
RGAABVTTCYRGAWN
NWTCYRGAABVTTCY		 SELEX
Yin et al.(2017)
HSF2_FL_Methyl-HT-SELEX 		0.343 0.542
Hsf2
M09231_2.00 		Mus musculus
VGAABVTTCKVGAN
NTCBMGAABVTTCB		 Misc
Kulakovskiy et al.(2013)
HSF2_MOUSE.H11MO.0.A 		0.334 0.531
For this family, TFs with SR scores > 0.318 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0085961 HSF 49 149
FBpp0110264 HSF 49 149
FBpp0110265 HSF 49 149
FBpp0110266 HSF 49 149

Links

Other HSF family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

217 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action