SFL1 (Saccharomyces cerevisiae)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00447 (HSF_DNA-bind) IPR000232 YOR140W T242487_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of autophagy; regulation of protein localization by the Cvt pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Orthologous to human HSF4 (heat shock transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SFL1
M01556_2.00		 Saccharomyces cerevisiae
NNTYCTTCTWNN
NNWAGAAGRANN		 PBM
Zhu et al.(2009)
Sfl1		 (Direct) (Direct)
SFL1
M08585_2.00		 Saccharomyces cerevisiae
GAAGCTTC
GAAGCTTC		 Misc
DeBoer et al.(2011)
YOR140W_605		 (Direct) (Direct)
SFL1
M08586_2.00		 Saccharomyces cerevisiae
WHWHNDWYCTTCBRTNHDNDN
NHNHDNAYVGAAGRWHNDWDW		 Misc
DeBoer et al.(2011)
YOR140W_839		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.318 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01556_2.00 HSF 65 206

DNA Binding Domains

Protein ID Domain From To Sequence
YOR140W HSF 65 206

Links

Other HSF family TFs
Other Saccharomyces cerevisiae TFs

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41 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action