ENSP00000410851-D3 (Bos grunniens)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00447 (HSF_DNA-bind) IPR000232 ENSP00000410851-D3 T242616_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HSFY2
M03326_2.00
Homo sapiens
WTCGAWNVRWTCGAW

WTCGAWYBNWTCGAW
SELEX
Jolma et al.(2013)
HSFY2_1
0.347 0.500
HSFY2
M03327_2.00
Homo sapiens
CRTTCGAWW

WWTCGAAYG
SELEX
Jolma et al.(2013)
HSFY2_2
0.347 0.500
HSFY2
M03328_2.00
Homo sapiens
DTCGAAHSNWTCGAW

WTCGAWNSDTTCGAH
SELEX
Jolma et al.(2013)
HSFY2_3
0.347 0.500
HSFY1
M05515_2.00
Homo sapiens
NDTVGAAYGWTTCGAAYGB

VCRTTCGAAWCRTTCBAHN
SELEX
Yin et al.(2017)
HSFY1_eDBD_HT-SELEX_1
0.347 0.500
HSFY1
M05516_2.00
Homo sapiens
DTTCGAAHSDTTCGAAH

DTTCGAAHSDTTCGAAH
SELEX
Yin et al.(2017)
HSFY1_eDBD_HT-SELEX_2
0.347 0.500
HSFY2
M05511_2.00
Homo sapiens
NDTVGAAYGWTTCGAAYGB

VCRTTCGAAWCRTTCBAHN
SELEX
Yin et al.(2017)
HSFY2_eDBD_HT-SELEX_1
0.347 0.500
HSFY2
M05512_2.00
Homo sapiens
DTTCGAAHSDTTCGAAH

DTTCGAAHSDTTCGAAH
SELEX
Yin et al.(2017)
HSFY2_eDBD_HT-SELEX_2
0.347 0.500
HSFY1
M05517_2.00
Homo sapiens
NDTRGAATGTTTRGAATGB

VCATTCYAAACATTCYAHN
SELEX
Yin et al.(2017)
HSFY1_eDBD_Methyl-HT-SELEX_1
0.347 0.500
HSFY1
M05518_2.00
Homo sapiens
DTTCGAAHSDTTCGAAH

DTTCGAAHSDTTCGAAH
SELEX
Yin et al.(2017)
HSFY1_eDBD_Methyl-HT-SELEX_2
0.347 0.500
HSFY2
M05513_2.00
Homo sapiens
NDWRGAAYGTTTRGAAYGB

VCRTTCYAAACRTTCYWHN
SELEX
Yin et al.(2017)
HSFY2_eDBD_Methyl-HT-SELEX_1
0.347 0.500
HSFY2
M05514_2.00
Homo sapiens
DTTCGAAHSDTTCGAAH

DTTCGAAHSDTTCGAAH
SELEX
Yin et al.(2017)
HSFY2_eDBD_Methyl-HT-SELEX_2
0.347 0.500
For this family, TFs with SR scores > 0.318 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000410851-D3 HSF 29 141

Links

Other HSF family TFs
Other Bos grunniens TFs

57 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSP00000306549-D3 Bos grunniens ENSP00000306549-D3 N 0.494
ENSFCAG00000025614 Felis catus ENSFCAG00000025614 I 0.450
ENSDNOG00000043873 Dasypus novemcinctus ENSDNOG00000043873 I 0.440
ENSCAFG00000023024 Canis familiaris ENSCAFG00000023024 I 0.429
ENSDNOG00000015218 Dasypus novemcinctus ENSDNOG00000015218 I 0.429
ENSCAFG00000025411 Canis familiaris ENSCAFG00000025411 I 0.423
ENSCAFG00000031919 Canis familiaris ENSCAFG00000031919 I 0.423
ENSTBEG00000002283 Tupaia belangeri ENSTBEG00000002283 I 0.418
ENSSSCG00000012734 Sus scrofa ENSSSCG00000012734 I 0.398
ENSCJAG00000004097 Callithrix jacchus ENSCJAG00000004097 I 0.389
Cmyd_10018130 Chelonia mydas Cmyd_10018130 I 0.378
ENSMEUG00000003908 Macropus eugenii ENSMEUG00000003908 I 0.377
ENSTTRG00000000641 Tursiops truncatus ENSTTRG00000000641 N 0.377
ENSMMUG00000002887 Macaca mulatta ENSMMUG00000002887 I 0.377
ENSP00000359444 Macaca fascicularis ENSP00000359444 I 0.377
ENSPANG00000004032 Papio anubis ENSPANG00000004032 I 0.377
ENSTTRG00000003386 Tursiops truncatus ENSTTRG00000003386 N 0.377
ENSGGOG00000022734 Gorilla gorilla ENSGGOG00000022734 I 0.376
ENSMODG00000027398 Monodelphis domestica ENSMODG00000027398 I 0.375
HSFX2 Homo sapiens ENSG00000268738 I 0.373
HSFX1 Homo sapiens ENSG00000171116 I 0.373
ENSAMEG00000009347 Ailuropoda melanoleuca ENSAMEG00000009347 I 0.372
ENSLAFG00000016976 Loxodonta africana ENSLAFG00000016976 I 0.369
Hsfy2 Rattus norvegicus ENSRNOG00000038569 I 0.368
Hsfy2 Mus musculus ENSMUSG00000045336 I 0.368
ENSCSAG00000007182 Chlorocebus sabaeus ENSCSAG00000007182 I 0.367
ENSECAG00000000093 Equus caballus ENSECAG00000000093 I 0.365
ENSAPLG00000009652 Anas platyrhynchos ENSAPLG00000009652 I 0.365
ENSNLEG00000013483 Nomascus leucogenys ENSNLEG00000013483 I 0.365
ENSLAFG00000010861 Loxodonta africana ENSLAFG00000010861 I 0.364
Afo_R012751 Aptenodytes forsteri Afo_R012751 I 0.357
HSFY2 Homo sapiens ENSG00000169953 D 0.354
HSFY1 Homo sapiens ENSG00000172468 D 0.354
ENSLACG00000012431 Latimeria chalumnae ENSLACG00000012431 I 0.352
ENSPPYG00000020808 Pongo abelii ENSPPYG00000020808 I 0.352
ENSMGAG00000014469 Meleagris gallopavo ENSMGAG00000014469 I 0.350
ENSECAG00000009040 Equus caballus ENSECAG00000009040 N 0.342
ENSMLUG00000015387 Myotis lucifugus ENSMLUG00000015387 I 0.341
ENSOANG00000001091 Ornithorhynchus anatinus ENSOANG00000001091 I 0.341
ENSMLUG00000024907 Myotis lucifugus ENSMLUG00000024907 I 0.340
ENSBTAG00000046306 Bos taurus ENSBTAG00000046306 I 0.338
ENSGALG00000028720 Gallus gallus ENSGALG00000028720 I 0.338
ENSOANG00000028803 Ornithorhynchus anatinus ENSOANG00000028803 I 0.338
ENSP00000306472-D2 Bos grunniens ENSP00000306472-D2 N 0.334
Pvit_14501 Pogona vitticeps Pvit_14501 I 0.331
ENSMICG00000013064 Microcebus murinus ENSMICG00000013064 N 0.330
ENSACAG00000008631 Anolis carolinensis ENSACAG00000008631 I 0.330
ENSVPAG00000004400 Vicugna pacos ENSVPAG00000004400 I 0.329
ENSMGAG00000005814 Meleagris gallopavo ENSMGAG00000005814 I 0.327
ENSMGAG00000014467 Meleagris gallopavo ENSMGAG00000014467 I 0.327
Aan_R010039 Calypte anna Aan_R010039 I 0.326
Ogr08578 Ophisaurus gracilis Ogr08578 I 0.325
ENSOANG00000012192 Ornithorhynchus anatinus ENSOANG00000012192 I 0.323
ENSMODG00000028107 Monodelphis domestica ENSMODG00000028107 I 0.321
Tal_R003042 Tyto alba Tal_R003042 I 0.320
ENSLOCG00000014483 Lepisosteus oculatus ENSLOCG00000014483 I 0.320
ENSGALG00000027212 Gallus gallus ENSGALG00000027212 I 0.319