L898_g5106 (Steinernema monticolum)
HSF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00447 (HSF_DNA-bind) IPR000232 L898_g5106 T243688_2.00 WormBase:ParaSite (2015-Oct-22)

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
hsf-1
M00682_2.00
Caenorhabditis elegans
TTCYAGAA

TTCTRGAA
PBM
Narasimhan et al.(2015)
pTH10796
0.376 0.635
HSF1
M03329_2.00
Homo sapiens
GAANVTTCBVGAA

TTCBVGAABNTTC
SELEX
Jolma et al.(2013)
HSF1_1
0.355 0.542
HSF1
M03330_2.00
Homo sapiens
GAANRTTCBAGAA

TTCTVGAAYNTTC
SELEX
Jolma et al.(2013)
HSF1_2
0.355 0.542
HSF1
M05523_2.00
Homo sapiens
VGAABVTTCBVGAWN

NWTCBVGAABVTTCB
SELEX
Yin et al.(2017)
HSF1_eDBD_HT-SELEX
0.355 0.542
HSF1
M05525_2.00
Homo sapiens
VGAANRTTCKVGAAN

NTTCBMGAAYNTTCB
SELEX
Yin et al.(2017)
HSF1_FL_HT-SELEX
0.355 0.542
HSF1
M07977_2.00
Homo sapiens
GDCSYGGGTTCRADYCCC

GGGRHTYGAACCCRSGHC
ChIP-seq
Gerstein et al.(2012)
HepG2_HSF1_Stanford
0.355 0.542
HSF1
M09230_2.00
Homo sapiens
NRGAANNTTCYRGAA

TTCYRGAANNTTCYN
Misc
Kulakovskiy et al.(2013)
HSF1_HUMAN.H11MO.0.A
0.355 0.542
Hsf1
M09232_2.00
Mus musculus
NRGAANNTTCYRGAA

TTCYRGAANNTTCYN
Misc
Kulakovskiy et al.(2013)
HSF1_MOUSE.H11MO.0.A
0.355 0.542
HSF1
M09592_2.00
Homo sapiens
NNBBCYRGAANNTTCYRGVV

BBCYRGAANNTTCYRGVVNN
Misc
Heinz et al.(2010)
HepG2-HSF1_GSE31477
0.355 0.542
Hsf1
M09593_2.00
Mus musculus
NRGAANNTTCYRGAA

TTCYRGAANNTTCYN
Misc
Heinz et al.(2010)
Striatum-HSF1_GSE38000
0.355 0.542
HSF1
M10863_2.00
Homo sapiens
NGAAHNTTCY

RGAANDTTCN
Transfac
Matys et al.(2006)
V$HSF1_01
0.355 0.542
HSF1
M10864_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q5_01
0.355 0.542
HSF1
M10865_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q5
0.355 0.542
HSF1
M10866_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q6_01
0.355 0.542
HSF1
M10867_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q6
0.355 0.542
HSF1
M10868_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF_Q6
0.355 0.542
HSF1
M05524_2.00
Homo sapiens
RGAANRTTCYRGAWN

NWTCYRGAAYNTTCY
SELEX
Yin et al.(2017)
HSF1_eDBD_Methyl-HT-SELEX
0.355 0.542
HSF1
M05526_2.00
Homo sapiens
RGAANVTTCYRGAWN

NWTCYRGAABNTTCY
SELEX
Yin et al.(2017)
HSF1_FL_Methyl-HT-SELEX
0.355 0.542
Hsf
M03908_2.00
Drosophila melanogaster
BVGAANRTTCTVGAANN

NNTTCBAGAAYNTTCBV
SELEX
Nitta et al.(2015)
Hsf_1
0.333 0.479
Hsf
M03909_2.00
Drosophila melanogaster
NVGAAYNTTCBAGAANN

NNTTCTVGAANRTTCBN
SELEX
Nitta et al.(2015)
Hsf_2
0.333 0.479
Hsf
M03910_2.00
Drosophila melanogaster
NVGAAYNTTCTVGAANN

NNTTCBAGAANRTTCBN
SELEX
Nitta et al.(2015)
Hsf_3
0.333 0.479
Hsf
M03911_2.00
Drosophila melanogaster
NVGAANRTTCBAGAANN

NNTTCTVGAAYNTTCBN
SELEX
Nitta et al.(2015)
Hsf_4
0.333 0.479
Hsf
M06388_2.00
Drosophila melanogaster
KMGAADNTTCKMGA

TCKMGAANHTTCKM
B1H
Zhu et al.(2011)
Hsf_FlyReg_FBgn0001222
0.333 0.479
Hsf
M10869_2.00
Drosophila melanogaster
HTTCK

MGAAD
Transfac
Matys et al.(2006)
I$HSF_01
0.333 0.479
Hsf
M10870_2.00
Drosophila melanogaster
MGAADMGAADMGAAD

HTTCKHTTCKHTTCK
Transfac
Matys et al.(2006)
I$HSF_02
0.333 0.479
Hsf
M10871_2.00
Drosophila melanogaster
MGAADHTTCKHTTCK

MGAADMGAADHTTCK
Transfac
Matys et al.(2006)
I$HSF_03
0.333 0.479
Hsf
M10872_2.00
Drosophila melanogaster
MGAADHTTCKMGAAD

HTTCKMGAADHTTCK
Transfac
Matys et al.(2006)
I$HSF_04
0.333 0.479
Hsf
M10873_2.00
Drosophila melanogaster
HTTCKHTTCKMGAAD

HTTCKMGAADMGAAD
Transfac
Matys et al.(2006)
I$HSF_05
0.333 0.479
Hsf2
M09231_2.00
Mus musculus
VGAABVTTCKVGAN

NTCBMGAABVTTCB
Misc
Kulakovskiy et al.(2013)
HSF2_MOUSE.H11MO.0.A
0.326 0.510
hsf2
M02248_2.00
Danio rerio
NNNWGTTCTATNN

NNATAGAACWNNN
PBM
Weirauch et al.(2014)
pTH9010
0.325 0.490
HSF2
M03324_2.00
Homo sapiens
GAANVTTCTAGAA

TTCTAGAABNTTC
SELEX
Jolma et al.(2013)
HSF2_1
0.319 0.500
HSF2
M02744_2.00
Homo sapiens
GAABGTTCTRGA

TCYAGAACVTTC
SELEX
Jolma et al.(2010)
HSF2_dimertrimer
0.319 0.500
HSF2
M05505_2.00
Homo sapiens
VGAABVTTCBVGAWN

NWTCBVGAABVTTCB
SELEX
Yin et al.(2017)
HSF2_eDBD_HT-SELEX
0.319 0.500
HSF2
M05507_2.00
Homo sapiens
VGAANNTTCBVGAAN

NTTCBVGAANNTTCB
SELEX
Yin et al.(2017)
HSF2_FL_HT-SELEX
0.319 0.500
HSF2
M09229_2.00
Homo sapiens
VGAABVTTCKVGAN

NTCBMGAABVTTCB
Misc
Kulakovskiy et al.(2013)
HSF2_HUMAN.H11MO.0.A
0.319 0.500
HSF2
M10859_2.00
Homo sapiens
VGAANNWTCB

VGAWNNTTCB
Transfac
Matys et al.(2006)
V$HSF2_01
0.319 0.500
HSF2
M10860_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF2_02
0.319 0.500
HSF2
M10861_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF2_Q6
0.319 0.500
HSF2
M05506_2.00
Homo sapiens
RGAABVTTCYRGAWN

NWTCYRGAABVTTCY
SELEX
Yin et al.(2017)
HSF2_eDBD_Methyl-HT-SELEX
0.319 0.500
HSF2
M05508_2.00
Homo sapiens
RGAABVTTCYRGAWN

NWTCYRGAABVTTCY
SELEX
Yin et al.(2017)
HSF2_FL_Methyl-HT-SELEX
0.319 0.500
For this family, TFs with SR scores > 0.318 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
L898_g5106.t1 HSF 26 128

Links

Other HSF family TFs
Other Steinernema monticolum TFs

188 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
L892_g820 Steinernema scapterisci L892_g820 I 0.640
L596_g17815 Steinernema carpocapsae L596_g17815 I 0.640
L889_g598 Steinernema feltiae L889_g598 I 0.634
L893_g7030 Steinernema glaseri L893_g7030 I 0.612
L898_g35624 Steinernema monticolum L898_g35624 I 0.541
DICVIV_08378 Dictyocaulus viviparus DICVIV_08378 I 0.427
NBR_0001979501 Nippostrongylus brasiliensis NBR_0001979501 I 0.426
HCOI00424600 Haemonchus contortus HCOI00424600 I 0.422
HCOI00423400 Haemonchus contortus HCOI00423400 I 0.422
ANCCEY_01944 Ancylostoma ceylanicum ANCCEY_01944 I 0.421
ANCCAN_00795 Ancylostoma caninum ANCCAN_00795 I 0.421
SVUK_0000175201 Strongylus vulgaris SVUK_0000175201 I 0.421
ACOC_0000071501 Angiostrongylus costaricensis ACOC_0000071501 I 0.419
SMUV_0000043201 Syphacia muris SMUV_0000043201 I 0.417
Minc16435 Meloidogyne incognita Minc16435 I 0.417
ASIM_0001223701 Anisakis simplex ASIM_0001223701 I 0.415
EVEC_0000124901 Enterobius vermicularis EVEC_0000124901 I 0.415
ALUE_0000801801 Ascaris lumbricoides ALUE_0000801801 I 0.413
TCNE_0000949901 Toxocara canis TCNE_0000949901 I 0.413
ASU_10106 Ascaris suum ASU_10106 I 0.413
MhA1_Contig1076.frz3.gene4 Meloidogyne hapla MhA1_Contig1076.frz3.gene4 I 0.407
LOAG_08901 Loa loa LOAG_08901 I 0.394
PTRK_0001079800 Parastrongyloides trichosuri PTRK_0001079800 I 0.394
BXY_0882000 Bursaphelenchus xylophilus BXY_0882000 I 0.387
CBN21581 Caenorhabditis brenneri CBN21581 I 0.384
SSTP_0000175600 Strongyloides stercoralis SSTP_0000175600 I 0.383
SVE_1155700 Strongyloides venezuelensis SVE_1155700 I 0.382
CRE28338 Caenorhabditis remanei CRE28338 I 0.382
hsf1 Danio rerio ENSDARG00000008818 I 0.380
SPAL_0001635100 Strongyloides papillosus SPAL_0001635100 I 0.380
LotgiG214431 Lottia gigantea LotgiG214431 I 0.379
SVE_0431600 Strongyloides venezuelensis SVE_0431600 I 0.378
SPAL_0000387400 Strongyloides papillosus SPAL_0000387400 I 0.377
BTMF_0001609701 Brugia timori BTMF_0001609701 I 0.376
nAv.1.0.1.g08619 Acanthocheilonema viteae nAv.1.0.1.g08619 I 0.376
Bm6746 Brugia malayi Bm6746 I 0.376
hsf-1 Caenorhabditis elegans WBGene00002004 D 0.376
nDi.2.2.2.g05157 Dirofilaria immitis nDi.2.2.2.g05157 I 0.375
ENSLOCG00000007411 Lepisosteus oculatus ENSLOCG00000007411 I 0.375
WBGene00238233 Onchocerca volvulus WBGene00238233 I 0.375
nOo.2.0.1.g06259 Onchocerca ochengi nOo.2.0.1.g06259 I 0.375
XP_002942927 Xenopus tropicalis XP_002942927 I 0.374
hsf1 Xenopus laevis XB-GENE-997145 I 0.374
hsf1.S Xenopus laevis XB-GENE-997146 I 0.374
HSF1 Anolis carolinensis ENSACAG00000012604 I 0.373
EEL_0000787901 Elaeophora elaphi EEL_0000787901 I 0.372
hsf1 Tetraodon nigroviridis ENSTNIG00000018157 I 0.371
ENSLACG00000013265 Latimeria chalumnae ENSLACG00000013265 I 0.369
ENSXMAG00000001905 Xiphophorus maculatus ENSXMAG00000001905 I 0.369
hsf1 Oryzias latipes ENSORLG00000001699 I 0.368
TCLT_0000441901 Thelazia callipaeda TCLT_0000441901 I 0.367
ENSONIG00000015330 Oreochromis niloticus ENSONIG00000015330 I 0.366
hsf1 Takifugu rubripes ENSTRUG00000000233 I 0.366
HSF1 Monodelphis domestica ENSMODG00000010663 I 0.365
Pvit_18730 Pogona vitticeps Pvit_18730 I 0.363
SSTP_0000347800 Strongyloides stercoralis SSTP_0000347800 I 0.362
ENSPFOG00000003038 Poecilia formosa ENSPFOG00000003038 I 0.362
GPLIN_000673800 Globodera pallida GPLIN_000673800 I 0.362
GPLIN_000109700 Globodera pallida GPLIN_000109700 I 0.362
ENSAMXG00000012942 Astyanax mexicanus ENSAMXG00000012942 I 0.359
nRc.2.0.1.g38503 Romanomermis culicivorax nRc.2.0.1.g38503 I 0.359
nLs.2.1.2.g08921 Litomosoides sigmodontis nLs.2.1.2.g08921 I 0.359
hsf1 Gasterosteus aculeatus ENSGACG00000010434 I 0.356
ENSTSYG00000006467 Tarsius syrichta ENSTSYG00000006467 I 0.355
ENSONIG00000010204 Oreochromis niloticus ENSONIG00000010204 I 0.355
hsf4 Oryzias latipes ENSORLG00000013768 I 0.355
ENSPPYG00000018969 Pongo abelii ENSPPYG00000018969 I 0.355
ENSPFOG00000004675 Poecilia formosa ENSPFOG00000004675 I 0.355
Pvit_07213 Pogona vitticeps Pvit_07213 I 0.355
Ogr12192 Ophisaurus gracilis Ogr12192 I 0.355
Hsf1 Rattus norvegicus ENSRNOG00000021732 I 0.355
ENSSTOG00000007173 Ictidomys tridecemlineatus ENSSTOG00000007173 I 0.355
ENSPANG00000005938 Papio anubis ENSPANG00000005938 I 0.355
XP_002937220 Xenopus tropicalis XP_002937220 I 0.355
HSF1 Loxodonta africana ENSLAFG00000021374 I 0.355
ENSCSAG00000008638 Chlorocebus sabaeus ENSCSAG00000008638 I 0.355
HSF1 Cavia porcellus ENSCPOG00000019305 I 0.355
hsf4 Danio rerio ENSDARG00000013251 I 0.355
HSF1 Dasypus novemcinctus ENSDNOG00000047071 I 0.355
Hsf1 Dipodomys ordii ENSDORG00000002333 I 0.355
HSF1 Canis familiaris ENSCAFG00000001563 I 0.355
ENSAMXG00000020456 Astyanax mexicanus ENSAMXG00000020456 I 0.355
CapteG130381 Capitella teleta CapteG130381 I 0.355
CGI_10007406 Crassostrea gigas CGI_10007406 I 0.355
ENSACAG00000013094 Anolis carolinensis ENSACAG00000013094 I 0.355
ENSAMEG00000005847 Ailuropoda melanoleuca ENSAMEG00000005847 I 0.355
HSF1 Homo sapiens ENSG00000185122 D 0.355
HSF1 Felis catus ENSFCAG00000007722 I 0.355
ENSXMAG00000005948 Xiphophorus maculatus ENSXMAG00000005948 I 0.355
hsf4 Gasterosteus aculeatus ENSGACG00000013994 I 0.355
ENSLOCG00000007976 Lepisosteus oculatus ENSLOCG00000007976 I 0.355
HSF1 Macaca mulatta ENSMMUG00000014728 I 0.355
ENSGMOG00000019339 Gadus morhua ENSGMOG00000019339 I 0.355
ENSMPUG00000006704 Mustela putorius furo ENSMPUG00000006704 I 0.355
Hsf1 Mus musculus ENSMUSG00000022556 D 0.355
HSF1 Gorilla gorilla ENSGGOG00000013602 I 0.355
ENSMLUG00000002310 Myotis lucifugus ENSMLUG00000002310 I 0.354
PTRK_0000997100 Parastrongyloides trichosuri PTRK_0000997100 I 0.354
ENSMLUG00000029200 Myotis lucifugus ENSMLUG00000029200 I 0.354
HSF1 Otolemur garnettii ENSOGAG00000028708 I 0.351
HSF1 Sus scrofa ENSSSCG00000005917 I 0.351
ENSOARG00000014186 Ovis aries ENSOARG00000014186 I 0.351
HSF1 Procavia capensis ENSPCAG00000006962 I 0.351
ENSP00000332698-D1 Bos grunniens ENSP00000332698-D1 I 0.351
HSF1 Bos taurus ENSBTAG00000020751 I 0.351
HSF1 Pteropus vampyrus ENSPVAG00000009267 I 0.350
snap_masked-nMf.1.1.scaf11979-processed-gene-0.4 Meloidogyne floridensis snap_masked-nMf.1.1.scaf11979-processed-gene-0.4 I 0.349
HSF1 Equus caballus ENSECAG00000000621 I 0.348
nRc.2.0.1.g30983 Romanomermis culicivorax nRc.2.0.1.g30983 I 0.348
HSF1 Ochotona princeps ENSOPRG00000004863 I 0.348
HSF1 Echinops telfairi ENSETEG00000002048 I 0.348
ENSMLUG00000015849 Myotis lucifugus ENSMLUG00000015849 I 0.347
ENSTNIG00000002981 Tetraodon nigroviridis ENSTNIG00000002981 I 0.344
Sakowv30012471m.g Saccoglossus kowalevskii Sakowv30012471m.g I 0.343
RO3G_12112 Rhizopus oryzae RO3G_12112 I 0.342
SMU15027452 Schmidtea mediterranea SMU15027452 I 0.339
ENSSHAG00000010769 Sarcophilus harrisii ENSSHAG00000010769 I 0.338
Gfo_R015956 Geospiza fortis Gfo_R015956 I 0.337
ENSFALG00000007632 Ficedula albicollis ENSFALG00000007632 I 0.337
ENSAPLG00000005338 Anas platyrhynchos ENSAPLG00000005338 I 0.337
e_gw.6.354.1 Branchiostoma floridae e_gw.6.354.1 I 0.337
HSF4 Gallus gallus ENSGALG00000003224 I 0.337
HSF4 Monodelphis domestica ENSMODG00000006228 I 0.337
Brh_R001747 Buceros rhinoceros Brh_R001747 I 0.337
HSF4 Meleagris gallopavo ENSMGAG00000000886 I 0.337
hsf3 Xenopus tropicalis XB-GENE-1021762 I 0.337
HSF4 Taeniopygia guttata ENSTGUG00000006716 I 0.337
Aan_R011648 Calypte anna Aan_R011648 I 0.337
Afo_R009212 Aptenodytes forsteri Afo_R009212 I 0.337
SPAL_0000387600 Strongyloides papillosus SPAL_0000387600 I 0.334
ENSDNOG00000048985 Dasypus novemcinctus ENSDNOG00000048985 I 0.334
Hsf Drosophila yakuba FBgn0066133 I 0.333
GM19926 Drosophila sechellia FBgn0174812 I 0.333
GG20992 Drosophila erecta FBgn0113176 I 0.333
Hsf Drosophila melanogaster FBgn0001222 D 0.333
ENSAPLG00000007598 Anas platyrhynchos ENSAPLG00000007598 I 0.333
ML078939a Mnemiopsis leidyi ML078939a I 0.330
ENSLOCG00000014654 Lepisosteus oculatus ENSLOCG00000014654 I 0.330
GF12282 Drosophila ananassae FBgn0089319 I 0.330
ENSLACG00000010304 Latimeria chalumnae ENSLACG00000010304 I 0.330
GH20850 Drosophila grimshawi FBgn0128312 I 0.330
ENSAMXG00000008481 Astyanax mexicanus ENSAMXG00000008481 I 0.330
GI20955 Drosophila mojavensis FBgn0143689 I 0.329
GJ20676 Drosophila virilis FBgn0207814 I 0.329
SVE_1156000 Strongyloides venezuelensis SVE_1156000 I 0.329
GK19495 Drosophila willistoni FBgn0221493 I 0.327
ENSONIG00000001677 Oreochromis niloticus ENSONIG00000001677 I 0.327
O9G_004185 Rozella allomycis O9G_004185 I 0.327
BXY_0893300 Bursaphelenchus xylophilus BXY_0893300 I 0.326
Hsf2 Mus musculus ENSMUSG00000019878 D 0.326
KGM_01871 Danaus plexippus KGM_01871 I 0.326
HSF1 Callithrix jacchus ENSCJAG00000021431 I 0.326
hsf2 Danio rerio ENSDARG00000053097 D 0.325
ENSGMOG00000000596 Gadus morhua ENSGMOG00000000596 I 0.325
hsf2 Oryzias latipes ENSORLG00000015498 I 0.325
ENSAMXG00000017965 Astyanax mexicanus ENSAMXG00000017965 I 0.325
Hsf2 Dipodomys ordii ENSDORG00000012571 I 0.324
DME_0000290701 Dracunculus medinensis DME_0000290701 I 0.323
ENSOCUG00000022713 Oryctolagus cuniculus ENSOCUG00000022713 I 0.320
Alligator_sinensis_CCG021829.1 Alligator sinensis Alligator_sinensis_CCG021829.1 I 0.320
HSF2 Cavia porcellus ENSCPOG00000007509 I 0.319
HSF2 Bos taurus ENSBTAG00000012946 I 0.319
ENSAMEG00000007373 Ailuropoda melanoleuca ENSAMEG00000007373 I 0.319
ENSCHOG00000010951 Choloepus hoffmanni ENSCHOG00000010951 I 0.319
HSF2 Callithrix jacchus ENSCJAG00000003956 I 0.319
ENSCSAG00000016240 Chlorocebus sabaeus ENSCSAG00000016240 I 0.319
HSF2 Dasypus novemcinctus ENSDNOG00000031260 I 0.319
ENSNLEG00000013721 Nomascus leucogenys ENSNLEG00000013721 I 0.319
HSF2 Procavia capensis ENSPCAG00000016109 I 0.319
hsf2.L Xenopus laevis XB-GENE-954983 I 0.319
ENSPANG00000022516 Papio anubis ENSPANG00000022516 I 0.319
HSF2 Otolemur garnettii ENSOGAG00000015721 I 0.319
ENSPPYG00000016976 Pongo abelii ENSPPYG00000016976 I 0.319
HSF2 Pan troglodytes ENSPTRG00000018561 I 0.319
L804_06549 Cryptococcus gattii L804_06549 I 0.319
ENSTBEG00000013569 Tupaia belangeri ENSTBEG00000013569 I 0.319
ENSP00000357440-D1 Bos grunniens ENSP00000357440-D1 I 0.319
HSF2 Oryctolagus cuniculus ENSOCUG00000025991 I 0.319
ENSOARG00000008274 Ovis aries ENSOARG00000008274 I 0.319
HSF2 Gorilla gorilla ENSGGOG00000023192 I 0.319
HSF2 Homo sapiens ENSG00000025156 D 0.319
HSF2 Echinops telfairi ENSETEG00000006154 I 0.319
HSF2 Loxodonta africana ENSLAFG00000006440 I 0.319
ENSMICG00000006415 Microcebus murinus ENSMICG00000006415 I 0.319
ENSMPUG00000014453 Mustela putorius furo ENSMPUG00000014453 I 0.319
HSF2 Macaca mulatta ENSMMUG00000007910 I 0.319
HSF2 Myotis lucifugus ENSMLUG00000002355 I 0.319
HSF2 Erinaceus europaeus ENSEEUG00000000435 I 0.319