IRF3 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000126456 T244079_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF3
M03331_2.00
Homo sapiens
NNRRAANGGAAACCGAAACYR

YRGTTTCGGTTTCCNTTYYNN
SELEX
Jolma et al.(2013)
IRF3_1
(Direct) (Direct)
IRF3
M05531_2.00
Homo sapiens
DCVGTTTCSNSGAAACCGMAASN

NSTTKCGGTTTCSNSGAAACBGH
SELEX
Yin et al.(2017)
IRF3_eDBD_HT-SELEX
(Direct) (Direct)
IRF3
M05532_2.00
Homo sapiens
KCDSTTTCCHGGAAAMNRAWAV

BTWTYNKTTTCCDGGAAASHGM
SELEX
Yin et al.(2017)
IRF3_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
IRF3
M05533_2.00
Homo sapiens
HSGAAAVBGAAACYGAAACN

NGTTTCRGTTTCVBTTTCSD
SELEX
Yin et al.(2017)
IRF3_FL_HT-SELEX
(Direct) (Direct)
IRF3
M05534_2.00
Homo sapiens
HGGAAABBGAAASBGAAASN

NSTTTCVSTTTCVVTTTCCD
SELEX
Yin et al.(2017)
IRF3_FL_Methyl-HT-SELEX
(Direct) (Direct)
IRF3
M09234_2.00
Homo sapiens
RRRARDGAAAVDGRAASNRA

TYNSTTYCHBTTTCHYTYYY
Misc
Kulakovskiy et al.(2013)
IRF3_HUMAN.H11MO.0.B
(Direct) (Direct)
IRF3
M10883_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF3_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf3
M00174_2.00
Mus musculus
RDWNBGMAAS

STTKCVNWHY
PBM
Badis et al.(2009)
Irf3_3985
0.856 0.856
Irf3
M09241_2.00
Mus musculus
RRRARDGAAAVDGRAASNRA

TYNSTTYCHBTTTCHYTYYY
Misc
Kulakovskiy et al.(2013)
IRF3_MOUSE.H11MO.0.A
0.856 0.856
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000310127 IRF 7 110
ENSP00000366344 IRF 7 110
ENSP00000400378 IRF 7 103
ENSP00000469113 IRF 7 110
ENSP00000470140 IRF 7 110
ENSP00000470431 IRF 7 110
ENSP00000470436 IRF 7 110
ENSP00000470905 IRF 7 102
ENSP00000471358 IRF 7 110
ENSP00000471896 IRF 7 110
ENSP00000472223 IRF 7 110
ENSP00000473128 IRF 7 110
ENSP00000473176 IRF 7 110

Links

Other IRF family TFs
Other Homo sapiens TFs

38 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
IRF3 Gorilla gorilla ENSGGOG00000000499 I 1.000
ENSNLEG00000005277 Nomascus leucogenys ENSNLEG00000005277 I 1.000
ENSPTRG00000011309 Pan troglodytes ENSPTRG00000011309 I 1.000
ENSPPYG00000010260 Pongo abelii ENSPPYG00000010260 I 1.000
ENSPANG00000014697 Papio anubis ENSPANG00000014697 I 0.952
IRF3 Macaca mulatta ENSMMUG00000022735 I 0.952
ENSCSAG00000002477 Chlorocebus sabaeus ENSCSAG00000002477 I 0.952
ENSMMUP00000031524 Macaca fascicularis ENSMMUP00000031524 I 0.952
ENSAMEG00000013892 Ailuropoda melanoleuca ENSAMEG00000013892 I 0.941
ENSMPUG00000002477 Mustela putorius furo ENSMPUG00000002477 I 0.941
IRF3 Callithrix jacchus ENSCJAG00000003637 I 0.923
ENSSTOG00000022900 Ictidomys tridecemlineatus ENSSTOG00000022900 I 0.923
IRF3 Myotis lucifugus ENSMLUG00000023427 I 0.913
Myotis_brandtii_IRF3_10017659 Myotis brandtii Myotis_brandtii_IRF3_10017659 I 0.913
IRF3 Microcebus murinus ENSMICG00000001752 I 0.909
IRF3 Pteropus vampyrus ENSPVAG00000010968 I 0.902
Irf3 Mus musculus ENSMUSG00000003184 D 0.902
IRF3 Felis catus ENSFCAG00000006074 I 0.894
IRF3 Tursiops truncatus ENSTTRG00000005531 I 0.894
ENSBTAP00000031815-D1 Bos grunniens ENSBTAP00000031815-D1 I 0.882
ENSOARG00000013335 Ovis aries ENSOARG00000013335 I 0.882
IRF3 Bos taurus ENSBTAG00000006633 I 0.882
IRF3 Sus scrofa ENSSSCG00000003178 I 0.875
IRF3 Canis familiaris ENSCAFG00000003594 I 0.875
IRF3 Equus caballus ENSECAG00000018265 I 0.865
Irf3 Rattus norvegicus ENSRNOG00000043388 I 0.856
IRF3 Cavia porcellus ENSCPOG00000026146 I 0.846
IRF3 Oryctolagus cuniculus ENSOCUG00000027558 I 0.846
IRF3 Dasypus novemcinctus ENSDNOG00000040858 I 0.837
IRF3 Procavia capensis ENSPCAG00000008633 I 0.817
IRF3 Ochotona princeps ENSOPRG00000001971 I 0.817
IRF3 Otolemur garnettii ENSOGAG00000011935 I 0.810
IRF3 Sorex araneus ENSSARG00000006248 I 0.779
IRF3 Monodelphis domestica ENSMODG00000013603 N 0.745
IRF3 Loxodonta africana ENSLAFG00000028074 I 0.737
ENSMEUG00000004666 Macropus eugenii ENSMEUG00000004666 I 0.729
ENSTBEG00000003466 Tupaia belangeri ENSTBEG00000003466 I 0.727