IRF5 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000128604 T244080_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF5
M03332_2.00		 Homo sapiens
YCGAAACCGAAMCY
RGKTTCGGTTTCGR		 SELEX
Jolma et al.(2013)
IRF5_1		 (Direct) (Direct)
IRF5
M03333_2.00		 Homo sapiens
HACCGAAACYV
BRGTTTCGGTD		 SELEX
Jolma et al.(2013)
IRF5_2		 (Direct) (Direct)
IRF5
M05535_2.00		 Homo sapiens
NCGAAACCGAWACH
DGTWTCGGTTTCGN		 SELEX
Yin et al.(2017)
IRF5_eDBD_HT-SELEX		 (Direct) (Direct)
IRF5
M05536_2.00		 Homo sapiens
NYGAWACYGAWACH
DGTWTCRGTWTCRN		 SELEX
Yin et al.(2017)
IRF5_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
IRF5
M05537_2.00		 Homo sapiens
NCGAAACCGAAACY
RGTTTCGGTTTCGN		 SELEX
Yin et al.(2017)
IRF5_FL_HT-SELEX		 (Direct) (Direct)
IRF5
M05538_2.00		 Homo sapiens
NYGAAACCGAWACY
RGTWTCGGTTTCRN		 SELEX
Yin et al.(2017)
IRF5_FL_Methyl-HT-SELEX		 (Direct) (Direct)
IRF5
M10884_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF5_Q3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf5
M00177_2.00 		Mus musculus
NNNHGADASH
DSTHTCDNNN		 PBM
Badis et al.(2009)
Irf5_3874 		0.909 0.909
IRF5
M02256_2.00 		Oryctolagus cuniculus
NHCGAAACYN
NRGTTTCGDN		 PBM
Weirauch et al.(2014)
pTH9272 		0.841 0.841
irf5.L
M02260_2.00 		Xenopus laevis
VNCGADACHN
NDGTHTCGNB		 PBM
Weirauch et al.(2014)
pTH9367 		0.767 0.767
IRF6
M02253_2.00 		Gallus gallus
NNMCNAAWNN
NNWTTNGKNN		 PBM
Weirauch et al.(2014)
pTH9178 		0.724 0.724
IRF6
M02254_2.00 		Meleagris gallopavo
NRNCGAWACY
RGTWTCGNYN		 PBM
Weirauch et al.(2014)
pTH9210 		0.724 0.724
irf6.2
M02259_2.00 		Xenopus tropicalis
NVNHGAWACH
DGTWTCDNBN		 PBM
Weirauch et al.(2014)
pTH9302 		0.705 0.705
Irf6
M00176_2.00 		Mus musculus
NNNHGADASN
NSTHTCDNNN		 PBM
Badis et al.(2009)
Irf6_3803 		0.722 0.722
IRF6
M05527_2.00 		Homo sapiens
RGTWTCGNNNNNNYGAWACY
RGTWTCRNNNNNNCGAWACY		 SELEX
Yin et al.(2017)
IRF6_eDBD_HT-SELEX 		0.722 0.722
IRF6
M05529_2.00 		Homo sapiens
ACCGAAACT
AGTTTCGGT		 SELEX
Yin et al.(2017)
IRF6_FL_HT-SELEX 		0.722 0.722
IRF6
M05528_2.00 		Homo sapiens
RGTWTCGNHNNDNYGAWACY
RGTWTCRNHNNDNCGAWACY		 SELEX
Yin et al.(2017)
IRF6_eDBD_Methyl-HT-SELEX 		0.722 0.722
IRF6
M05530_2.00 		Homo sapiens
ACCGAWACY
RGTWTCGGT		 SELEX
Yin et al.(2017)
IRF6_FL_Methyl-HT-SELEX 		0.722 0.722
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000249375 IRF 16 121
ENSP00000349770 IRF 16 121
ENSP00000385352 IRF 16 121
ENSP00000417454 IRF 16 59
ENSP00000417770 IRF 16 121
ENSP00000418037 IRF 16 121
ENSP00000418534 IRF 16 120
ENSP00000419056 IRF 16 106
ENSP00000419149 IRF 16 121
ENSP00000419950 IRF 16 121
ENSP00000420274 IRF 16 79
ENSP00000480058 IRF 16 121
ENSP00000483292 IRF 16 120

Links

Other IRF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

121 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action