IRF5 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000128604 T244080_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF5
M03332_2.00
Homo sapiens
YCGAAACCGAAMCY

RGKTTCGGTTTCGR
SELEX
Jolma et al.(2013)
IRF5_1
(Direct) (Direct)
IRF5
M03333_2.00
Homo sapiens
HACCGAAACYV

BRGTTTCGGTD
SELEX
Jolma et al.(2013)
IRF5_2
(Direct) (Direct)
IRF5
M05535_2.00
Homo sapiens
NCGAAACCGAWACH

DGTWTCGGTTTCGN
SELEX
Yin et al.(2017)
IRF5_eDBD_HT-SELEX
(Direct) (Direct)
IRF5
M05536_2.00
Homo sapiens
NYGAWACYGAWACH

DGTWTCRGTWTCRN
SELEX
Yin et al.(2017)
IRF5_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
IRF5
M05537_2.00
Homo sapiens
NCGAAACCGAAACY

RGTTTCGGTTTCGN
SELEX
Yin et al.(2017)
IRF5_FL_HT-SELEX
(Direct) (Direct)
IRF5
M05538_2.00
Homo sapiens
NYGAAACCGAWACY

RGTWTCGGTTTCRN
SELEX
Yin et al.(2017)
IRF5_FL_Methyl-HT-SELEX
(Direct) (Direct)
IRF5
M10884_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF5_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf5
M00177_2.00
Mus musculus
NNNHGADASH

DSTHTCDNNN
PBM
Badis et al.(2009)
Irf5_3874
0.971 0.971
IRF5
M02256_2.00
Oryctolagus cuniculus
NHCGAAACYN

NRGTTTCGDN
PBM
Weirauch et al.(2014)
pTH9272
0.962 0.962
irf5.L
M02260_2.00
Xenopus laevis
VNCGADACHN

NDGTHTCGNB
PBM
Weirauch et al.(2014)
pTH9367
0.721 0.721
IRF6
M02253_2.00
Gallus gallus
NNMCNAAWNN

NNWTTNGKNN
PBM
Weirauch et al.(2014)
pTH9178
0.724 0.724
IRF6
M02254_2.00
Meleagris gallopavo
NRNCGAWACY

RGTWTCGNYN
PBM
Weirauch et al.(2014)
pTH9210
0.724 0.724
irf6.2
M02259_2.00
Xenopus tropicalis
NVNHGAWACH

DGTWTCDNBN
PBM
Weirauch et al.(2014)
pTH9302
0.733 0.733
Irf6
M00176_2.00
Mus musculus
NNNHGADASN

NSTHTCDNNN
PBM
Badis et al.(2009)
Irf6_3803
0.722 0.722
IRF6
M05527_2.00
Homo sapiens
RGTWTCGNNNNNNYGAWACY

RGTWTCRNNNNNNCGAWACY
SELEX
Yin et al.(2017)
IRF6_eDBD_HT-SELEX
0.722 0.722
IRF6
M05529_2.00
Homo sapiens
ACCGAAACT

AGTTTCGGT
SELEX
Yin et al.(2017)
IRF6_FL_HT-SELEX
0.722 0.722
IRF6
M05528_2.00
Homo sapiens
RGTWTCGNHNNDNYGAWACY

RGTWTCRNHNNDNCGAWACY
SELEX
Yin et al.(2017)
IRF6_eDBD_Methyl-HT-SELEX
0.722 0.722
IRF6
M05530_2.00
Homo sapiens
ACCGAWACY

RGTWTCGGT
SELEX
Yin et al.(2017)
IRF6_FL_Methyl-HT-SELEX
0.722 0.722
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000249375 IRF 16 121
ENSP00000349770 IRF 16 121
ENSP00000385352 IRF 16 121
ENSP00000417454 IRF 16 59
ENSP00000417770 IRF 16 121
ENSP00000418037 IRF 16 121
ENSP00000418534 IRF 16 120
ENSP00000419056 IRF 16 106
ENSP00000419149 IRF 16 121
ENSP00000419950 IRF 16 121
ENSP00000420274 IRF 16 79
ENSP00000480058 IRF 16 121
ENSP00000483292 IRF 16 120

Links

Other IRF family TFs
Other Homo sapiens TFs

121 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Irf6 Mus musculus ENSMUSG00000026638 D 0.722
Irf5 Mus musculus ENSMUSG00000029771 D 0.984
irf6.2 Xenopus tropicalis XB-GENE-5910331 D 0.733
IRF6 Gallus gallus ENSGALG00000001405 D 0.756
irf5.L Xenopus laevis XB-GENE-998629 D 0.767
IRF5 Oryctolagus cuniculus ENSOCUG00000010101 D 0.962
IRF6 Meleagris gallopavo ENSMGAG00000004431 D 0.756
IRF6 Homo sapiens ENSG00000117595 D 0.722
ENSPPYG00000017989 Pongo abelii ENSPPYG00000017989 I 1.000
ENSPSIG00000003597 Pelodiscus sinensis ENSPSIG00000003597 I 0.744
IRF6 Pan troglodytes ENSPTRG00000001941 I 0.722
IRF5 Pan troglodytes ENSPTRG00000019675 I 1.000
IRF6 Pteropus vampyrus ENSPVAG00000004865 I 0.722
IRF5 Pteropus vampyrus ENSPVAG00000015756 I 0.920
Irf6 Rattus norvegicus ENSRNOG00000005082 I 0.722
Irf5 Rattus norvegicus ENSRNOG00000007437 I 0.971
ENSSHAG00000006683 Sarcophilus harrisii ENSSHAG00000006683 I 0.895
ENSPPYG00000000253 Pongo abelii ENSPPYG00000000253 I 0.722
ENSPFOG00000014077 Poecilia formosa ENSPFOG00000014077 I 0.711
IRF6 Oryctolagus cuniculus ENSOCUG00000004035 I 0.722
IRF5 Otolemur garnettii ENSOGAG00000009608 I 0.920
IRF6 Otolemur garnettii ENSOGAG00000010708 I 0.722
ENSONIG00000007600 Oreochromis niloticus ENSONIG00000007600 I 0.752
ENSONIG00000018961 Oreochromis niloticus ENSONIG00000018961 I 0.700
IRF5 Ochotona princeps ENSOPRG00000006148 I 0.971
irf6 Oryzias latipes ENSORLG00000000511 I 0.722
ENSPANG00000011328 Papio anubis ENSPANG00000011328 I 0.722
ENSPANG00000018384 Papio anubis ENSPANG00000018384 I 0.981
IRF6 Procavia capensis ENSPCAG00000006456 I 0.722
ENSPFOG00000005876 Poecilia formosa ENSPFOG00000005876 I 0.711
ENSPFOG00000013528 Poecilia formosa ENSPFOG00000013528 I 0.743
ENSOARG00000020948 Ovis aries ENSOARG00000020948 I 0.700
IRF6 Sus scrofa ENSSSCG00000015612 I 0.723
irf5 Takifugu rubripes ENSTRUG00000000641 I 0.756
ENSP00000349770-D1 Bos grunniens ENSP00000349770-D1 I 0.990
ENSP00000349770-D2 Bos grunniens ENSP00000349770-D2 I 0.722
ENSP00000349770 Macaca fascicularis ENSP00000349770 I 0.981
ENSP00000355988 Macaca fascicularis ENSP00000355988 I 0.722
Myotis_brandtii_IRF5_10012830 Myotis brandtii Myotis_brandtii_IRF5_10012830 I 0.962
Myotis_brandtii_IRF6_10012270 Myotis brandtii Myotis_brandtii_IRF6_10012270 I 0.722
Pvit_14327 Pogona vitticeps Pvit_14327 I 0.856
Pvit_15428 Pogona vitticeps Pvit_15428 I 0.756
irf6.2.L Xenopus laevis XB-GENE-5910427 I 0.744
irf6 Xenopus tropicalis XB-GENE-876410 I 0.733
irf6.S Xenopus laevis XB-GENE-876421 I 0.744
irf5 Xenopus tropicalis XB-GENE-998624 I 0.767
Cmyd_10010684 Chelonia mydas Cmyd_10010684 I 0.733
Cmyd_10002838 Chelonia mydas Cmyd_10002838 I 0.856
Alligator_sinensis_CCG015719.1 Alligator sinensis Alligator_sinensis_CCG015719.1 I 0.756
ENSSTOG00000004858 Ictidomys tridecemlineatus ENSSTOG00000004858 I 0.971
ENSSTOG00000028204 Ictidomys tridecemlineatus ENSSTOG00000028204 I 0.711
IRF6 Taeniopygia guttata ENSTGUG00000001485 I 0.756
irf5 Tetraodon nigroviridis ENSTNIG00000003346 I 0.733
irf6 Tetraodon nigroviridis ENSTNIG00000014635 I 0.700
ENSTSYG00000010982 Tarsius syrichta ENSTSYG00000010982 I 0.722
IRF6 Tursiops truncatus ENSTTRG00000001121 I 0.722
IRF6 Vicugna pacos ENSVPAG00000010247 I 0.722
ENSXMAG00000013056 Xiphophorus maculatus ENSXMAG00000013056 I 0.743
Afo_R001981 Aptenodytes forsteri Afo_R001981 I 0.756
Alligator_sinensis_CCG003696.1 Alligator sinensis Alligator_sinensis_CCG003696.1 I 0.756
Alligator_sinensis_CCG004564.1 Alligator sinensis Alligator_sinensis_CCG004564.1 I 0.878
IRF5 Sus scrofa ENSSSCG00000016573 I 0.971
ENSOARG00000012720 Ovis aries ENSOARG00000012720 I 0.722
IRF6 Anolis carolinensis ENSACAG00000005931 I 0.733
ENSCSAG00000009970 Chlorocebus sabaeus ENSCSAG00000009970 I 0.981
ENSCSAG00000015263 Chlorocebus sabaeus ENSCSAG00000015263 I 0.722
irf5 Danio rerio ENSDARG00000045681 I 0.767
irf6 Danio rerio ENSDARG00000101986 I 0.711
IRF6 Dasypus novemcinctus ENSDNOG00000001694 I 0.722
IRF5 Dasypus novemcinctus ENSDNOG00000013370 I 0.905
Irf6 Dipodomys ordii ENSDORG00000008891 I 0.722
Irf5 Dipodomys ordii ENSDORG00000010627 I 0.962
IRF6 Equus caballus ENSECAG00000007482 I 0.722
IRF5 Equus caballus ENSECAG00000009902 I 0.981
IRF5 Erinaceus europaeus ENSEEUG00000014653 I 0.911
IRF5 Echinops telfairi ENSETEG00000002100 I 0.939
IRF6 Cavia porcellus ENSCPOG00000023829 I 0.722
IRF5 Cavia porcellus ENSCPOG00000000246 I 0.962
ENSAMEG00000005109 Ailuropoda melanoleuca ENSAMEG00000005109 I 0.981
ENSAMEG00000017984 Ailuropoda melanoleuca ENSAMEG00000017984 I 0.722
ENSAMXG00000004616 Astyanax mexicanus ENSAMXG00000004616 I 0.711
ENSAPLG00000006203 Anas platyrhynchos ENSAPLG00000006203 I 0.778
ENSAPLG00000009319 Anas platyrhynchos ENSAPLG00000009319 I 0.756
IRF6 Bos taurus ENSBTAG00000002849 I 0.722
IRF5 Bos taurus ENSBTAG00000004989 I 0.989
IRF5 Canis familiaris ENSCAFG00000001611 I 0.971
IRF6 Canis familiaris ENSCAFG00000011971 I 0.722
IRF6 Choloepus hoffmanni ENSCHOG00000010399 I 0.722
IRF6 Callithrix jacchus ENSCJAG00000015032 I 0.722
IRF5 Callithrix jacchus ENSCJAG00000018061 I 0.981
IRF6 Echinops telfairi ENSETEG00000008368 I 0.722
ENSFALG00000000504 Ficedula albicollis ENSFALG00000000504 I 0.702
IRF5 Felis catus ENSFCAG00000000956 I 0.971
IRF5 Myotis lucifugus ENSMLUG00000001406 I 0.962
IRF6 Myotis lucifugus ENSMLUG00000004509 I 0.722
IRF5 Macaca mulatta ENSMMUG00000018478 I 0.981
IRF6 Macaca mulatta ENSMMUG00000022065 I 0.722
IRF6 Monodelphis domestica ENSMODG00000002539 I 0.733
IRF5 Monodelphis domestica ENSMODG00000014710 I 0.895
ENSMPUG00000003106 Mustela putorius furo ENSMPUG00000003106 I 0.722
ENSMPUG00000006034 Mustela putorius furo ENSMPUG00000006034 I 0.981
ENSNLEG00000001962 Nomascus leucogenys ENSNLEG00000001962 I 0.722
ENSNLEG00000012454 Nomascus leucogenys ENSNLEG00000012454 I 1.000
IRF5 Ornithorhynchus anatinus ENSOANG00000011449 I 0.905
IRF6 Ornithorhynchus anatinus ENSOANG00000013718 I 0.733
IRF5 Microcebus murinus ENSMICG00000000138 I 0.971
ENSMEUG00000014941 Macropus eugenii ENSMEUG00000014941 I 0.733
IRF6 Felis catus ENSFCAG00000015138 I 0.722
irf5 Gasterosteus aculeatus ENSGACG00000000695 I 0.744
irf6 Gasterosteus aculeatus ENSGACG00000000990 I 0.700
IRF6 Gorilla gorilla ENSGGOG00000006214 I 0.722
IRF5 Gorilla gorilla ENSGGOG00000012013 I 1.000
ENSGMOG00000007264 Gadus morhua ENSGMOG00000007264 I 0.756
ENSLACG00000005750 Latimeria chalumnae ENSLACG00000005750 I 0.778
ENSLACG00000018600 Latimeria chalumnae ENSLACG00000018600 I 0.744
IRF5 Loxodonta africana ENSLAFG00000021568 I 0.962
ENSLOCG00000011297 Lepisosteus oculatus ENSLOCG00000011297 I 0.733
ENSLOCG00000015563 Lepisosteus oculatus ENSLOCG00000015563 I 0.756
ENSMEUG00000002435 Macropus eugenii ENSMEUG00000002435 I 0.924
ENSOARG00000003908 Ovis aries ENSOARG00000003908 I 0.990