IRF5 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000128604 T244080_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF5
M03332_2.00
Homo sapiens
YCGAAACCGAAMCY

RGKTTCGGTTTCGR
SELEX
Jolma et al.(2013)
IRF5_1
(Direct) (Direct)
IRF5
M03333_2.00
Homo sapiens
HACCGAAACYV

BRGTTTCGGTD
SELEX
Jolma et al.(2013)
IRF5_2
(Direct) (Direct)
IRF5
M05535_2.00
Homo sapiens
NCGAAACCGAWACH

DGTWTCGGTTTCGN
SELEX
Yin et al.(2017)
IRF5_eDBD_HT-SELEX
(Direct) (Direct)
IRF5
M05536_2.00
Homo sapiens
NYGAWACYGAWACH

DGTWTCRGTWTCRN
SELEX
Yin et al.(2017)
IRF5_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
IRF5
M05537_2.00
Homo sapiens
NCGAAACCGAAACY

RGTTTCGGTTTCGN
SELEX
Yin et al.(2017)
IRF5_FL_HT-SELEX
(Direct) (Direct)
IRF5
M05538_2.00
Homo sapiens
NYGAAACCGAWACY

RGTWTCGGTTTCRN
SELEX
Yin et al.(2017)
IRF5_FL_Methyl-HT-SELEX
(Direct) (Direct)
IRF5
M10884_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF5_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf5
M00177_2.00
Mus musculus
NNNHGADASH

DSTHTCDNNN
PBM
Badis et al.(2009)
Irf5_3874
0.971 0.971
IRF5
M02256_2.00
Oryctolagus cuniculus
NHCGAAACYN

NRGTTTCGDN
PBM
Weirauch et al.(2014)
pTH9272
0.962 0.962
irf5.L
M02260_2.00
Xenopus laevis
VNCGADACHN

NDGTHTCGNB
PBM
Weirauch et al.(2014)
pTH9367
0.721 0.721
IRF6
M02253_2.00
Gallus gallus
NNMCNAAWNN

NNWTTNGKNN
PBM
Weirauch et al.(2014)
pTH9178
0.724 0.724
IRF6
M02254_2.00
Meleagris gallopavo
NRNCGAWACY

RGTWTCGNYN
PBM
Weirauch et al.(2014)
pTH9210
0.724 0.724
irf6.2
M02259_2.00
Xenopus tropicalis
NVNHGAWACH

DGTWTCDNBN
PBM
Weirauch et al.(2014)
pTH9302
0.733 0.733
Irf6
M00176_2.00
Mus musculus
NNNHGADASN

NSTHTCDNNN
PBM
Badis et al.(2009)
Irf6_3803
0.722 0.722
IRF6
M05527_2.00
Homo sapiens
RGTWTCGNNNNNNYGAWACY

RGTWTCRNNNNNNCGAWACY
SELEX
Yin et al.(2017)
IRF6_eDBD_HT-SELEX
0.722 0.722
IRF6
M05529_2.00
Homo sapiens
ACCGAAACT

AGTTTCGGT
SELEX
Yin et al.(2017)
IRF6_FL_HT-SELEX
0.722 0.722
IRF6
M05528_2.00
Homo sapiens
RGTWTCGNHNNDNYGAWACY

RGTWTCRNHNNDNCGAWACY
SELEX
Yin et al.(2017)
IRF6_eDBD_Methyl-HT-SELEX
0.722 0.722
IRF6
M05530_2.00
Homo sapiens
ACCGAWACY

RGTWTCGGT
SELEX
Yin et al.(2017)
IRF6_FL_Methyl-HT-SELEX
0.722 0.722
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000249375 IRF 16 121
ENSP00000349770 IRF 16 121
ENSP00000385352 IRF 16 121
ENSP00000417454 IRF 16 59
ENSP00000417770 IRF 16 121
ENSP00000418037 IRF 16 121
ENSP00000418534 IRF 16 120
ENSP00000419056 IRF 16 106
ENSP00000419149 IRF 16 121
ENSP00000419950 IRF 16 121
ENSP00000420274 IRF 16 79
ENSP00000480058 IRF 16 121
ENSP00000483292 IRF 16 120

Links

Other IRF family TFs
Other Homo sapiens TFs

121 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
28152.m000905 Ricinus communis 28152.m000905 N 0.000
29661.m000902 Ricinus communis 29661.m000902 N 0.000
30170.m013752 Ricinus communis 30170.m013752 N 0.000
AMTR_s00079p00088960 Amborella trichopoda AMTR_s00079p00088960 N 0.000
AMTR_s00137p00051070 Amborella trichopoda AMTR_s00137p00051070 N 0.000
AMTR_s00137p00087340 Amborella trichopoda AMTR_s00137p00087340 N 0.000
Aquca_026_00293 Aquilegia coerulea Aquca_026_00293 N 0.000
Aquca_042_00143 Aquilegia coerulea Aquca_042_00143 N 0.000
BGIOSGA002703 Oryza indica BGIOSGA002703 N 0.000
BGIOSGA010258 Oryza indica BGIOSGA010258 N 0.000
BGIOSGA010454 Oryza indica BGIOSGA010454 N 0.000
BGIOSGA026049 Oryza indica BGIOSGA026049 N 0.000
Bo1g003550 Brassica oleracea Bo1g003550 N 0.000
Bo2g168020 Brassica oleracea Bo2g168020 N 0.000
Bo5g132850 Brassica oleracea Bo5g132850 N 0.000
Bo7g063630 Brassica oleracea Bo7g063630 N 0.000
Bo7g099150 Brassica oleracea Bo7g099150 N 0.000
Bo7g118580 Brassica oleracea Bo7g118580 N 0.000
Bo8g079200 Brassica oleracea Bo8g079200 N 0.000
Bo9g018500 Brassica oleracea Bo9g018500 N 0.000
Bo9g019150 Brassica oleracea Bo9g019150 N 0.000
Bostr.0568s0168 Boechera stricta Bostr.0568s0168 N 0.000
Bostr.7867s1612 Boechera stricta Bostr.7867s1612 N 0.000
Bra011772 Brassica rapa Bra011772 N 0.000
Bra012164 Brassica rapa Bra012164 N 0.000
Bra012913 Brassica rapa Bra012913 N 0.000
Bra017831 Brassica rapa Bra017831 N 0.000
Bra031833 Brassica rapa Bra031833 N 0.000
Bra036040 Brassica rapa Bra036040 N 0.000
Bra037847 Brassica rapa Bra037847 N 0.000
BRADI1G22920 Brachypodium distachyon BRADI1G22920 N 0.000
Cagra.0342s0030 Capsella grandiflora Cagra.0342s0030 N 0.000
Cagra.10957s0002 Capsella grandiflora Cagra.10957s0002 N 0.000
Cagra.4491s0014 Capsella grandiflora Cagra.4491s0014 N 0.000
Carubv10005616m.g Capsella rubella Carubv10005616m.g N 0.000
Carubv10017944m.g Capsella rubella Carubv10017944m.g N 0.000
Carubv10027507m.g Capsella rubella Carubv10027507m.g N 0.000
cassava22449.valid.m1 Manihot esculenta cassava22449.valid.m1 N 0.000
cassava226.valid.m1 Manihot esculenta cassava226.valid.m1 N 0.000
cassava35733.valid.m1 Manihot esculenta cassava35733.valid.m1 N 0.000
cassava60.valid.m1 Manihot esculenta cassava60.valid.m1 N 0.000
cassava6185.valid.m1 Manihot esculenta cassava6185.valid.m1 N 0.000
cassava7497.valid.m1 Manihot esculenta cassava7497.valid.m1 N 0.000
cassava9459.m1 Manihot esculenta cassava9459.m1 N 0.000
Ca_02208 Cicer arietinum Ca_02208 N 0.000
Ca_09342 Cicer arietinum Ca_09342 N 0.000
chr1.CM0088.550.nd Lotus japonicus chr1.CM0088.550.nd N 0.000
chr4.CM0128.270.nc Lotus japonicus chr4.CM0128.270.nc N 0.000
chr5.CM0200.600.nd Lotus japonicus chr5.CM0200.600.nd N 0.000
Ciclev10003746m.g Citrus clementina Ciclev10003746m.g N 0.000
Ciclev10013705m.g Citrus clementina Ciclev10013705m.g N 0.000
Ciclev10026374m.g Citrus clementina Ciclev10026374m.g N 0.000
Ciclev10029274m.g Citrus clementina Ciclev10029274m.g N 0.000
Cla007208 Citrullus lanatus Cla007208 N 0.000
Cla014228 Citrullus lanatus Cla014228 N 0.000
Cla020920 Citrullus lanatus Cla020920 N 0.000
Cucsa.031350 Cucumis sativus Cucsa.031350 N 0.000
Cucsa.103050 Cucumis sativus Cucsa.103050 N 0.000
Cucsa.352730 Cucumis sativus Cucsa.352730 N 0.000
estExt_gwp_gw1.C_2030014 Physcomitrella patens estExt_gwp_gw1.C_2030014 N 0.000
Eucgr.F00115 Eucalyptus grandis Eucgr.F00115 N 0.000
Eucgr.G01261 Eucalyptus grandis Eucgr.G01261 N 0.000
Eucgr.H02293 Eucalyptus grandis Eucgr.H02293 N 0.000
evm.TU.supercontig_106.63 Carica papaya evm.TU.supercontig_106.63 N 0.000
evm.TU.supercontig_21.100 Carica papaya evm.TU.supercontig_21.100 N 0.000
evm.TU.supercontig_6.40 Carica papaya evm.TU.supercontig_6.40 N 0.000
e_gw1.19.226.1 Physcomitrella patens e_gw1.19.226.1 N 0.000
gene02557-v1.0-hybrid Fragaria vesca gene02557-v1.0-hybrid N 0.000
gene05722-v1.0-hybrid Fragaria vesca gene05722-v1.0-hybrid N 0.000
gene25541-v1.0-hybrid Fragaria vesca gene25541-v1.0-hybrid N 0.000
GLYMA01G40010 Glycine max GLYMA01G40010 N 0.000
GLYMA05G22120 Glycine max GLYMA05G22120 N 0.000
GLYMA08G48040 Glycine max GLYMA08G48040 N 0.000
GLYMA10G40421 Glycine max GLYMA10G40421 N 0.000
GLYMA11G05280 Glycine max GLYMA11G05280 N 0.000
GLYMA13G07590 Glycine max GLYMA13G07590 N 0.000
GLYMA14G09750 Glycine max GLYMA14G09750 N 0.000
GLYMA17G17540 Glycine max GLYMA17G17540 N 0.000
GLYMA17G35440 Glycine max GLYMA17G35440 N 0.000
GLYMA20G26910 Glycine max GLYMA20G26910 N 0.000
Gorai.005G232500 Gossypium raimondii Gorai.005G232500 N 0.000
Gorai.007G056300 Gossypium raimondii Gorai.007G056300 N 0.000
Gorai.007G222000 Gossypium raimondii Gorai.007G222000 N 0.000
Gorai.008G081100 Gossypium raimondii Gorai.008G081100 N 0.000
Gorai.009G218800 Gossypium raimondii Gorai.009G218800 N 0.000
Gorai.010G025100 Gossypium raimondii Gorai.010G025100 N 0.000
GRMZM2G017319 Zea mays GRMZM2G017319 N 0.000
GRMZM2G044902 Zea mays GRMZM2G044902 N 0.000
GRMZM2G132693 Zea mays GRMZM2G132693 N 0.000
GRMZM2G177110 Zea mays GRMZM2G177110 N 0.000
GSMUA_Achr2G13440_001 Musa acuminata GSMUA_Achr2G13440_001 N 0.000
GSMUA_Achr3G18860_001 Musa acuminata GSMUA_Achr3G18860_001 N 0.000
GSMUA_Achr3G29520_001 Musa acuminata GSMUA_Achr3G29520_001 N 0.000
GSMUA_Achr3G30130_001 Musa acuminata GSMUA_Achr3G30130_001 N 0.000
GSMUA_Achr4G13790_001 Musa acuminata GSMUA_Achr4G13790_001 N 0.000
GSMUA_Achr4G14150_001 Musa acuminata GSMUA_Achr4G14150_001 N 0.000
GSMUA_Achr4G32550_001 Musa acuminata GSMUA_Achr4G32550_001 N 0.000
GSMUA_Achr6G07770_001 Musa acuminata GSMUA_Achr6G07770_001 N 0.000
GSMUA_Achr7G26260_001 Musa acuminata GSMUA_Achr7G26260_001 N 0.000
GSMUA_Achr9G00580_001 Musa acuminata GSMUA_Achr9G00580_001 N 0.000
GSMUA_Achr9G21360_001 Musa acuminata GSMUA_Achr9G21360_001 N 0.000
gw1.167.132.1 Physcomitrella patens gw1.167.132.1 N 0.000
gw1.41.215.1 Physcomitrella patens gw1.41.215.1 N 0.000
LBD37 Arabidopsis thaliana AT5G67420 N 0.000
LBD37 Arabidopsis lyrata fgenesh2_kg.8__2670__AT5G67420.1 N 0.000
LBD38 Arabidopsis thaliana AT3G49940 N 0.000
LBD38 Arabidopsis lyrata scaffold_502015.1 N 0.000
LBD39 Arabidopsis lyrata fgenesh2_kg.7__297__AT4G37540.1 N 0.000
LBD39 Arabidopsis thaliana AT4G37540 N 0.000
LjSGA_036652.1 Lotus japonicus LjSGA_036652.1 N 0.000
LPERR01G01830 Leersia perrieri LPERR01G01830 N 0.000
LPERR03G19360 Leersia perrieri LPERR03G19360 N 0.000
LPERR07G17890 Leersia perrieri LPERR07G17890 N 0.000
Lus10007758.g Linum usitatissimum Lus10007758.g N 0.000
Lus10011530.g Linum usitatissimum Lus10011530.g N 0.000
Lus10018697.g Linum usitatissimum Lus10018697.g N 0.000
Lus10019292.g Linum usitatissimum Lus10019292.g N 0.000
MDP0000139025 Malus domestica MDP0000139025 N 0.000
MDP0000151330 Malus domestica MDP0000151330 N 0.000
MDP0000239820 Malus domestica MDP0000239820 N 0.000
MDP0000247079 Malus domestica MDP0000247079 N 0.000
MDP0000261146 Malus domestica MDP0000261146 N 0.000
MDP0000487015 Malus domestica MDP0000487015 N 0.000
MDP0000747679 Malus domestica MDP0000747679 N 0.000
MDP0000794101 Malus domestica MDP0000794101 N 0.000
mgf007319m Mimulus guttatus mgf007319m N 0.000
mgf016023m Mimulus guttatus mgf016023m N 0.000
mgf016064m Mimulus guttatus mgf016064m N 0.000
MLOC_11838 Hordeum vulgare MLOC_11838 N 0.000
MTR_1g106420 Medicago truncatula MTR_1g106420 N 0.000
MTR_4g095600 Medicago truncatula MTR_4g095600 N 0.000
MTR_5g015880 Medicago truncatula MTR_5g015880 N 0.000
MTR_7g007010 Medicago truncatula MTR_7g007010 N 0.000
OB01G11830 Oryza brachyantha OB01G11830 N 0.000
OB03G31560 Oryza brachyantha OB03G31560 N 0.000
OB03G33950 Oryza brachyantha OB03G33950 N 0.000
OBART01G01940 Oryza barthii OBART01G01940 N 0.000
OBART03G22820 Oryza barthii OBART03G22820 N 0.000
OBART03G25820 Oryza barthii OBART03G25820 N 0.000
OBART07G20600 Oryza barthii OBART07G20600 N 0.000
OGLUM01G02100 Oryza glumaepatula OGLUM01G02100 N 0.000
OGLUM03G23580 Oryza glumaepatula OGLUM03G23580 N 0.000
OGLUM03G26640 Oryza glumaepatula OGLUM03G26640 N 0.000
OGLUM07G20380 Oryza glumaepatula OGLUM07G20380 N 0.000
OLONG_015384 Oryza longistaminata OLONG_015384 N 0.000
OMERI03G20600 Oryza meridionalis OMERI03G20600 N 0.000
OMERI07G17270 Oryza meridionalis OMERI07G17270 N 0.000
ONIVA01G02110 Oryza nivara ONIVA01G02110 N 0.000
ONIVA03G24370 Oryza nivara ONIVA03G24370 N 0.000
ONIVA03G26970 Oryza nivara ONIVA03G26970 N 0.000
ONIVA07G19050 Oryza nivara ONIVA07G19050 N 0.000
OPUNC01G01670 Oryza punctata OPUNC01G01670 N 0.000
OPUNC03G21330 Oryza punctata OPUNC03G21330 N 0.000
OPUNC03G23160 Oryza punctata OPUNC03G23160 N 0.000
OPUNC07G19440 Oryza punctata OPUNC07G19440 N 0.000
OPUNC07G19460 Oryza punctata OPUNC07G19460 N 0.000
orange1.1g022591m.g Citrus sinensis orange1.1g022591m.g N 0.000
orange1.1g026365m.g Citrus sinensis orange1.1g026365m.g N 0.000
orange1.1g029809m.g Citrus sinensis orange1.1g029809m.g N 0.000
orange1.1g029970m.g Citrus sinensis orange1.1g029970m.g N 0.000
ORGLA01G0016600 Oryza glaberrima ORGLA01G0016600 N 0.000
ORGLA03G0213800 Oryza glaberrima ORGLA03G0213800 N 0.000
ORGLA03G0239300 Oryza glaberrima ORGLA03G0239300 N 0.000
ORGLA07G0157700 Oryza glaberrima ORGLA07G0157700 N 0.000
ORUFI01G02010 Oryza rufipogon ORUFI01G02010 N 0.000
ORUFI03G23490 Oryza rufipogon ORUFI03G23490 N 0.000
ORUFI03G26700 Oryza rufipogon ORUFI03G26700 N 0.000
ORUFI07G21460 Oryza rufipogon ORUFI07G21460 N 0.000
OS03G0445700 Oryza sativa OS03G0445700 N 0.000
OS03G0609500 Oryza sativa OS03G0609500 N 0.000
OS07G0589000 Oryza sativa OS07G0589000 N 0.000
Pavir.Ba01055 Panicum virgatum Pavir.Ba01055 N 0.000
Pavir.Bb01170 Panicum virgatum Pavir.Bb01170 N 0.000
Pavir.Ea00650 Panicum virgatum Pavir.Ea00650 N 0.000
Pavir.Ia03080 Panicum virgatum Pavir.Ia03080 N 0.000
Pavir.J11724 Panicum virgatum Pavir.J11724 N 0.000
Pavir.J16587 Panicum virgatum Pavir.J16587 N 0.000
Pavir.J18418 Panicum virgatum Pavir.J18418 N 0.000
PGSC0003DMG400021509 Solanum tuberosum PGSC0003DMG400021509 N 0.000
PGSC0003DMG400024936 Solanum tuberosum PGSC0003DMG400024936 N 0.000
PGSC0003DMG400025752 Solanum tuberosum PGSC0003DMG400025752 N 0.000
PK03075.1 Cannabis sativa PK03075.1 N 0.000
PK03169.1 Cannabis sativa PK03169.1 N 0.000
PK03977.1 Cannabis sativa PK03977.1 N 0.000
PK15647.1 Cannabis sativa PK15647.1 N 0.000
PK25954.1 Cannabis sativa PK25954.1 N 0.000
Pm005389 Prunus mume Pm005389 N 0.000
Pm021281 Prunus mume Pm021281 N 0.000
POPTR_0001s30280 Populus trichocarpa POPTR_0001s30280 N 0.000
POPTR_0002s12020 Populus trichocarpa POPTR_0002s12020 N 0.000
POPTR_0004s09920 Populus trichocarpa POPTR_0004s09920 N 0.000
POPTR_0005s18900 Populus trichocarpa POPTR_0005s18900 N 0.000
POPTR_0007s10010 Populus trichocarpa POPTR_0007s10010 N 0.000
POPTR_0009s09270 Populus trichocarpa POPTR_0009s09270 N 0.000
POPTR_0014s01770 Populus trichocarpa POPTR_0014s01770 N 0.000
PRUPE_ppa014964mg Prunus persica PRUPE_ppa014964mg N 0.000
PRUPE_ppa022806mg Prunus persica PRUPE_ppa022806mg N 0.000
SapurV1A.0019s0260 Salix purpurea SapurV1A.0019s0260 N 0.000
SapurV1A.0116s0210 Salix purpurea SapurV1A.0116s0210 N 0.000
SapurV1A.0336s0110 Salix purpurea SapurV1A.0336s0110 N 0.000
SapurV1A.0476s0230 Salix purpurea SapurV1A.0476s0230 N 0.000
SapurV1A.0845s0090 Salix purpurea SapurV1A.0845s0090 N 0.000
SapurV1A.2860s0030 Salix purpurea SapurV1A.2860s0030 N 0.000
Sb01g031790 Sorghum bicolor Sb01g031790 N 0.000
Sb02g038030 Sorghum bicolor Sb02g038030 N 0.000
Sb03g007270 Sorghum bicolor Sb03g007270 N 0.000
SELMODRAFT_105005 Selaginella moellendorffii SELMODRAFT_105005 N 0.000
SELMODRAFT_27399 Selaginella moellendorffii SELMODRAFT_27399 N 0.000
SELMODRAFT_37532 Selaginella moellendorffii SELMODRAFT_37532 N 0.000
SELMODRAFT_37566 Selaginella moellendorffii SELMODRAFT_37566 N 0.000
SELMODRAFT_37570 Selaginella moellendorffii SELMODRAFT_37570 N 0.000
SELMODRAFT_61520 Selaginella moellendorffii SELMODRAFT_61520 N 0.000
Si002412m.g Setaria italica Si002412m.g N 0.000
Si031011m.g Setaria italica Si031011m.g N 0.000
Si037275m.g Setaria italica Si037275m.g N 0.000
Solyc01g107190.2 Solanum lycopersicum Solyc01g107190.2 N 0.000
Solyc02g092550.2 Solanum lycopersicum Solyc02g092550.2 N 0.000
Solyc04g077990.2 Solanum lycopersicum Solyc04g077990.2 N 0.000
TCM_000766 Theobroma cacao TCM_000766 N 0.000
TCM_007211 Theobroma cacao TCM_007211 N 0.000
TCM_019459 Theobroma cacao TCM_019459 N 0.000
TCM_034722 Theobroma cacao TCM_034722 N 0.000
Thhalv10004811m.g Eutrema salsugineum Thhalv10004811m.g N 0.000
Thhalv10010666m.g Eutrema salsugineum Thhalv10010666m.g N 0.000
Thhalv10026086m.g Eutrema salsugineum Thhalv10026086m.g N 0.000
Traes_2AS_942884399 Triticum aestivum Traes_2AS_942884399 N 0.000
Traes_2BS_5DF7F4FEE Triticum aestivum Traes_2BS_5DF7F4FEE N 0.000
Traes_4AL_7241716B6 Triticum aestivum Traes_4AL_7241716B6 N 0.000
TRIUR3_28321 Triticum urartu TRIUR3_28321 N 0.000
VIT_03s0091g00670 Vitis vinifera VIT_03s0091g00670 N 0.000
VIT_07s0129g00330 Vitis vinifera VIT_07s0129g00330 N 0.000
VIT_18s0001g09250 Vitis vinifera VIT_18s0001g09250 N 0.000