IRF7 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000185507 T244084_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF7
M03337_2.00
Homo sapiens
HCGAAAVYGAAAVT

ABTTTCRBTTTCGD
SELEX
Jolma et al.(2013)
IRF7_1
(Direct) (Direct)
IRF7
M03338_2.00
Homo sapiens
RAANCGAAAWTCGNTTY

RAANCGAWTTTCGNTTY
SELEX
Jolma et al.(2013)
IRF7_2
(Direct) (Direct)
IRF7
M05547_2.00
Homo sapiens
NCGAAAVYGAAANYN

NRNTTTCRBTTTCGN
SELEX
Yin et al.(2017)
IRF7_eDBD_HT-SELEX
(Direct) (Direct)
IRF7
M05548_2.00
Homo sapiens
NNGAAARTGAAAVYR

YRBTTTCAYTTTCNN
SELEX
Yin et al.(2017)
IRF7_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
IRF7
M09238_2.00
Homo sapiens
RAAASYRAAW

WTTYRSTTTY
Misc
Kulakovskiy et al.(2013)
IRF7_HUMAN.H11MO.0.C
(Direct) (Direct)
IRF7
M10894_2.00
Homo sapiens
NNSGAAWNYGAAANYBDV

BHVRNTTTCRNWTTCSNN
Transfac
Matys et al.(2006)
V$IRF7_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf7
M02255_2.00
Mus musculus
DAHNNGAAAN

NTTTCNNDTH
PBM
Weirauch et al.(2014)
pTH3475
0.769 0.769
Irf7
M09244_2.00
Mus musculus
RAAASYRAAW

WTTYRSTTTY
Misc
Kulakovskiy et al.(2013)
IRF7_MOUSE.H11MO.0.C
0.769 0.769
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000329411 IRF 26 138
ENSP00000331803 IRF 13 125
ENSP00000380697 IRF 26 138
ENSP00000380700 IRF 26 138
ENSP00000380704 IRF 13 125
ENSP00000432403 IRF 26 138
ENSP00000433903 IRF 13 125
ENSP00000434524 IRF 13 118
ENSP00000434607 IRF 13 125
ENSP00000436696 IRF 13 125

Links

Other IRF family TFs
Other Homo sapiens TFs

29 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
IRF7 Pan troglodytes ENSPTRG00000003126 I 1.000
IRF7 Gorilla gorilla ENSGGOG00000008341 I 1.000
ENSPANG00000007390 Papio anubis ENSPANG00000007390 I 0.990
ENSNLEG00000008419 Nomascus leucogenys ENSNLEG00000008419 I 0.990
IRF7 Macaca mulatta ENSMMUG00000004014 I 0.990
ENSCSAG00000010883 Chlorocebus sabaeus ENSCSAG00000010883 I 0.981
IRF7 Callithrix jacchus ENSCJAG00000012124 I 0.894
ENSSTOG00000005711 Ictidomys tridecemlineatus ENSSTOG00000005711 I 0.875
Irf7 Dipodomys ordii ENSDORG00000014096 I 0.865
IRF7 Loxodonta africana ENSLAFG00000032120 I 0.846
IRF7 Dasypus novemcinctus ENSDNOG00000006293 I 0.846
IRF7 Oryctolagus cuniculus ENSOCUG00000002339 I 0.837
IRF7 Bos taurus ENSBTAG00000047680 I 0.827
Irf7 Rattus norvegicus ENSRNOG00000017414 I 0.827
ENSP00000329411-D1 Bos grunniens ENSP00000329411-D1 I 0.827
IRF7 Procavia capensis ENSPCAG00000010286 I 0.817
ENSMPUG00000008845 Mustela putorius furo ENSMPUG00000008845 I 0.817
IRF7 Tursiops truncatus ENSTTRG00000011148 I 0.808
ENSOARG00000006626 Ovis aries ENSOARG00000006626 I 0.808
ENSAMEG00000010613 Ailuropoda melanoleuca ENSAMEG00000010613 I 0.808
IRF7 Sus scrofa ENSSSCG00000012853 I 0.798
IRF7 Pteropus vampyrus ENSPVAG00000006873 I 0.798
IRF7 Echinops telfairi ENSETEG00000004078 I 0.793
IRF7 Otolemur garnettii ENSOGAG00000004986 I 0.788
IRF7 Equus caballus ENSECAG00000009744 I 0.788
Irf7 Mus musculus ENSMUSG00000025498 D 0.769
IRF7 Felis catus ENSFCAG00000031821 I 0.721
ENSSHAG00000004173 Sarcophilus harrisii ENSSHAG00000004173 I 0.712