IRF7 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000185507 T244084_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF7
M03337_2.00
Homo sapiens
HCGAAAVYGAAAVT

ABTTTCRBTTTCGD
SELEX
Jolma et al.(2013)
IRF7_1
(Direct) (Direct)
IRF7
M03338_2.00
Homo sapiens
RAANCGAAAWTCGNTTY

RAANCGAWTTTCGNTTY
SELEX
Jolma et al.(2013)
IRF7_2
(Direct) (Direct)
IRF7
M05547_2.00
Homo sapiens
NCGAAAVYGAAANYN

NRNTTTCRBTTTCGN
SELEX
Yin et al.(2017)
IRF7_eDBD_HT-SELEX
(Direct) (Direct)
IRF7
M05548_2.00
Homo sapiens
NNGAAARTGAAAVYR

YRBTTTCAYTTTCNN
SELEX
Yin et al.(2017)
IRF7_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
IRF7
M09238_2.00
Homo sapiens
RAAASYRAAW

WTTYRSTTTY
Misc
Kulakovskiy et al.(2013)
IRF7_HUMAN.H11MO.0.C
(Direct) (Direct)
IRF7
M10894_2.00
Homo sapiens
NNSGAAWNYGAAANYBDV

BHVRNTTTCRNWTTCSNN
Transfac
Matys et al.(2006)
V$IRF7_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf7
M02255_2.00
Mus musculus
DAHNNGAAAN

NTTTCNNDTH
PBM
Weirauch et al.(2014)
pTH3475
0.769 0.769
Irf7
M09244_2.00
Mus musculus
RAAASYRAAW

WTTYRSTTTY
Misc
Kulakovskiy et al.(2013)
IRF7_MOUSE.H11MO.0.C
0.769 0.769
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000329411 IRF 26 138
ENSP00000331803 IRF 13 125
ENSP00000380697 IRF 26 138
ENSP00000380700 IRF 26 138
ENSP00000380704 IRF 13 125
ENSP00000432403 IRF 26 138
ENSP00000433903 IRF 13 125
ENSP00000434524 IRF 13 118
ENSP00000434607 IRF 13 125
ENSP00000436696 IRF 13 125

Links

Other IRF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

29 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action