IRF9 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000213928 T244085_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF9
M03339_2.00		 Homo sapiens
AWCGAAACCGAAACY
RGTTTCGGTTTCGWT		 SELEX
Jolma et al.(2013)
IRF9_1		 (Direct) (Direct)
IRF9
M05549_2.00		 Homo sapiens
NCGAAASYGAAASYN
NRSTTTCRSTTTCGN		 SELEX
Yin et al.(2017)
IRF9_FL_HT-SELEX		 (Direct) (Direct)
IRF9
M05550_2.00		 Homo sapiens
NBGAAASYGAAASYN
NRSTTTCRSTTTCVN		 SELEX
Yin et al.(2017)
IRF9_FL_Methyl-HT-SELEX		 (Direct) (Direct)
IRF9
M09239_2.00		 Homo sapiens
GAAABHGAAAYT
ARTTTCDVTTTC		 Misc
Kulakovskiy et al.(2013)
IRF9_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF9
M02258_2.00 		Sus scrofa
WNYGAAASY
RSTTTCRNW		 PBM
Weirauch et al.(2014)
pTH9287 		0.894 0.894
IRF9
M02257_2.00 		Ochotona princeps
DNYRAAAVND
HNBTTTYRNH		 PBM
Weirauch et al.(2014)
pTH9337 		0.885 0.885
Irf9
M00173_2.00 		Mus musculus
NNNRAAANN
NNTTTYNNN		 PBM
Badis et al.(2009)
Isgf3g_2853 		0.800 0.800
Irf9
M09240_2.00 		Mus musculus
GAAABHGAAAYT
ARTTTCDVTTTC		 Misc
Kulakovskiy et al.(2013)
IRF9_MOUSE.H11MO.0.C 		0.800 0.800
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000313529 IRF 1 45
ENSP00000380073 IRF 11 115
ENSP00000453540 IRF 11 115
ENSP00000453974 IRF 11 50
ENSP00000454078 IRF 11 50
ENSP00000454095 IRF 11 115

Links

Other IRF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

45 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action