ENSP00000370343 (Macaca fascicularis)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00605 (IRF) IPR001346 ENSP00000370343 T244543_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf4
M00175_2.00
Mus musculus
NNNYGAWASN

NSTWTCRNNN
PBM
Badis et al.(2009)
Irf4_3476
1.000 1.000
IRF4
M03334_2.00
Homo sapiens
HCGAAACCGAAACYW

WRGTTTCGGTTTCGD
SELEX
Jolma et al.(2013)
IRF4_1
1.000 1.000
IRF4
M05539_2.00
Homo sapiens
NYGAAACYGAAACYN

NRGTTTCRGTTTCRN
SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX
1.000 1.000
IRF4
M07978_2.00
Homo sapiens
DNDVNNGWWVTGAVWVWN

NWBWBTCABWWCNNBHNH
ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha
1.000 1.000
IRF4
M09235_2.00
Homo sapiens
NDWDRRGGAASTGARAVH

DBTYTCASTTCCYYHWHN
Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A
1.000 1.000
Irf4
M09243_2.00
Mus musculus
NDAWVVRGAASTGARAVH

DBTYTCASTTCYBBWTHN
Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A
1.000 1.000
IRF4
M09595_2.00
Homo sapiens
HNYGAAASYD

HRSTTTCRND
Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465
1.000 1.000
IRF4
M10885_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_07
1.000 1.000
IRF4
M10886_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_08
1.000 1.000
IRF4
M10887_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q5_01
1.000 1.000
IRF4
M10888_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q5
1.000 1.000
IRF4
M10889_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q6
1.000 1.000
IRF4
M05540_2.00
Homo sapiens
NYGAAASYGAWASHN

NDSTWTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX
1.000 1.000
IRF8
M03335_2.00
Homo sapiens
HCGAAACYGAAACY

RGTTTCRGTTTCGD
SELEX
Jolma et al.(2013)
IRF8_1
0.797 0.797
IRF8
M03336_2.00
Homo sapiens
HCGAAACCGAAACT

AGTTTCGGTTTCGD
SELEX
Jolma et al.(2013)
IRF8_2
0.797 0.797
IRF8
M05541_2.00
Homo sapiens
NYGAAASYGAAASHN

NDSTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX
0.797 0.797
IRF8
M05543_2.00
Homo sapiens
NCGAAACYGAAACYN

NRGTTTCRGTTTCGN
SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX
0.797 0.797
IRF8
M09236_2.00
Homo sapiens
NDDDRRGGAASTGAAASYNN

NNRSTTTCASTTCCYYHHHN
Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B
0.797 0.797
Irf8
M09246_2.00
Mus musculus
NDDDRRGGAASTGAAASYNN

NNRSTTTCASTTCCYYHHHN
Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A
0.797 0.797
IRF8
M10890_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ICSBP_Q6
0.797 0.797
IRF8
M10891_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF8_Q6
0.797 0.797
IRF8
M05542_2.00
Homo sapiens
NYGAAASYGAAASYN

NRSTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX
0.797 0.797
IRF8
M05544_2.00
Homo sapiens
NYGAAASYGAAACYD

HRGTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX
0.797 0.797
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000370343 IRF 1 59

Links

Other IRF family TFs
Other Macaca fascicularis TFs

153 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSNLEG00000010631 Nomascus leucogenys ENSNLEG00000010631 I 1.000
Irf4 Mus musculus ENSMUSG00000021356 D 1.000
ENSOARG00000003822 Ovis aries ENSOARG00000003822 I 1.000
IRF4 Oryctolagus cuniculus ENSOCUG00000009374 I 1.000
ENSPPYG00000016161 Pongo abelii ENSPPYG00000016161 I 1.000
IRF4 Ochotona princeps ENSOPRG00000012683 I 1.000
ENSMPUG00000007848 Mustela putorius furo ENSMPUG00000007848 I 1.000
IRF4 Macaca mulatta ENSMMUG00000018513 I 1.000
IRF4 Homo sapiens ENSG00000137265 D 1.000
IRF4 Felis catus ENSFCAG00000022941 I 1.000
ENSGALG00000012830 Gallus gallus ENSGALG00000012830 I 1.000
IRF4 Gorilla gorilla ENSGGOG00000012342 I 1.000
IRF4 Myotis lucifugus ENSMLUG00000010058 I 1.000
IRF4 Loxodonta africana ENSLAFG00000017235 I 1.000
ENSPSIG00000011619 Pelodiscus sinensis ENSPSIG00000011619 I 1.000
IRF4 Pan troglodytes ENSPTRG00000017656 I 1.000
Brh_R000433 Buceros rhinoceros Brh_R000433 I 1.000
Alligator_sinensis_CCG015622.1 Alligator sinensis Alligator_sinensis_CCG015622.1 I 1.000
Cmyd_10011521 Chelonia mydas Cmyd_10011521 I 1.000
ENSP00000370343-D1 Bos grunniens ENSP00000370343-D1 I 1.000
Ogr05775 Ophisaurus gracilis Ogr05775 I 1.000
Gfo_R003357 Geospiza fortis Gfo_R003357 I 1.000
Afo_R014746 Aptenodytes forsteri Afo_R014746 I 1.000
Aan_R012662 Calypte anna Aan_R012662 I 1.000
Irf4 Rattus norvegicus ENSRNOG00000061070 I 1.000
IRF4 Pteropus vampyrus ENSPVAG00000005078 I 1.000
ENSSTOG00000011470 Ictidomys tridecemlineatus ENSSTOG00000011470 I 1.000
IRF4 Tupaia belangeri ENSTBEG00000012240 I 1.000
irf4b Takifugu rubripes ENSTRUG00000002946 I 1.000
IRF4 Taeniopygia guttata ENSTGUG00000002144 I 1.000
ENSFALG00000013071 Ficedula albicollis ENSFALG00000013071 I 1.000
IRF4 Otolemur garnettii ENSOGAG00000014574 I 1.000
ENSAPLG00000014646 Anas platyrhynchos ENSAPLG00000014646 I 1.000
ENSCSAG00000007164 Chlorocebus sabaeus ENSCSAG00000007164 I 1.000
IRF4 Cavia porcellus ENSCPOG00000003562 I 1.000
IRF4 Callithrix jacchus ENSCJAG00000019524 I 1.000
IRF4 Equus caballus ENSECAG00000016808 I 1.000
IRF4 Bos taurus ENSBTAG00000002929 I 1.000
ENSAMEG00000005976 Ailuropoda melanoleuca ENSAMEG00000005976 I 1.000
IRF4 Anolis carolinensis ENSACAG00000017711 I 1.000
IRF4 Echinops telfairi ENSETEG00000018472 I 1.000
Irf4 Dipodomys ordii ENSDORG00000014895 I 1.000
IRF4 Monodelphis domestica ENSMODG00000008383 I 0.983
irf4b Tetraodon nigroviridis ENSTNIG00000008222 I 0.983
IRF4 Tursiops truncatus ENSTTRG00000001849 I 0.983
ENSXMAG00000006246 Xiphophorus maculatus ENSXMAG00000006246 I 0.983
ENSMEUG00000002440 Macropus eugenii ENSMEUG00000002440 I 0.983
ENSLOCG00000013008 Lepisosteus oculatus ENSLOCG00000013008 I 0.983
ENSSHAG00000015592 Sarcophilus harrisii ENSSHAG00000015592 I 0.983
ENSPFOG00000000657 Poecilia formosa ENSPFOG00000000657 I 0.983
Tal_R010571 Tyto alba Tal_R010571 I 0.983
irf4b Oryzias latipes ENSORLG00000012712 I 0.983
ENSONIG00000006398 Oreochromis niloticus ENSONIG00000006398 I 0.983
ENSAMXG00000006093 Astyanax mexicanus ENSAMXG00000006093 I 0.966
IRF4 Ornithorhynchus anatinus ENSOANG00000006326 I 0.966
irf4b Gasterosteus aculeatus ENSGACG00000004966 I 0.966
ENSPANG00000023389 Papio anubis ENSPANG00000023389 I 0.949
irf4a Danio rerio ENSDARG00000006560 I 0.949
IRF4 Choloepus hoffmanni ENSCHOG00000012417 I 0.949
ENSMICG00000011721 Microcebus murinus ENSMICG00000011721 I 0.949
irf4 Xenopus tropicalis XB-GENE-988321 I 0.949
ENSGMOG00000016994 Gadus morhua ENSGMOG00000016994 I 0.949
ENSTSYG00000006495 Tarsius syrichta ENSTSYG00000006495 I 0.949
Myotis_brandtii_Irf4_10020370 Myotis brandtii Myotis_brandtii_Irf4_10020370 I 0.932
ENSAMXG00000016370 Astyanax mexicanus ENSAMXG00000016370 I 0.932
ENSAMXG00000012775 Astyanax mexicanus ENSAMXG00000012775 I 0.932
irf4a Oryzias latipes ENSORLG00000017242 I 0.898
irf4a Gasterosteus aculeatus ENSGACG00000016461 I 0.881
irf4a Tetraodon nigroviridis ENSTNIG00000005370 I 0.881
IRF4 Erinaceus europaeus ENSEEUG00000007703 I 0.881
ENSXMAG00000017015 Xiphophorus maculatus ENSXMAG00000017015 I 0.881
ENSPFOG00000015506 Poecilia formosa ENSPFOG00000015506 I 0.881
ENSONIG00000009637 Oreochromis niloticus ENSONIG00000009637 I 0.864
ENSLACG00000005859 Latimeria chalumnae ENSLACG00000005859 I 0.831
ENSXMAG00000003082 Xiphophorus maculatus ENSXMAG00000003082 I 0.814
IRF8 Procavia capensis ENSPCAG00000004460 I 0.814
irf8 Oryzias latipes ENSORLG00000018216 I 0.814
ENSAMXG00000003452 Astyanax mexicanus ENSAMXG00000003452 I 0.814
irf8 Takifugu rubripes ENSTRUG00000018213 I 0.814
ENSPFOG00000017639 Poecilia formosa ENSPFOG00000017639 I 0.814
IRF8 Loxodonta africana ENSLAFG00000010973 I 0.814
ENSFCAG00000029870 Felis catus ENSFCAG00000029870 I 0.814
Gfo_R000501 Geospiza fortis Gfo_R000501 I 0.797
ENSMPUG00000008641 Mustela putorius furo ENSMPUG00000008641 I 0.797
IRF8 Dasypus novemcinctus ENSDNOG00000038898 I 0.797
IRF8 Bos taurus ENSBTAG00000017824 I 0.797
ENSSTOG00000028363 Ictidomys tridecemlineatus ENSSTOG00000028363 I 0.797
IRF8 Homo sapiens ENSG00000140968 D 0.797
ENSSSCG00000023184 Sus scrofa ENSSSCG00000023184 I 0.797
Pvit_16863 Pogona vitticeps Pvit_16863 I 0.797
IRF8 Ochotona princeps ENSOPRG00000002139 I 0.797
IRF8 Monodelphis domestica ENSMODG00000004572 I 0.797
IRF8 Gorilla gorilla ENSGGOG00000028251 I 0.797
IRF8 Gallus gallus ENSGALG00000005757 I 0.797
Brh_R009589 Buceros rhinoceros Brh_R009589 I 0.797
Aan_R009222 Calypte anna Aan_R009222 I 0.797
ENSP00000268638 Macaca fascicularis ENSP00000268638 I 0.797
ENSSHAG00000006901 Sarcophilus harrisii ENSSHAG00000006901 I 0.797
IRF8 Macaca mulatta ENSMMUG00000008125 I 0.797
ENSLOCG00000001013 Lepisosteus oculatus ENSLOCG00000001013 I 0.797
ENSP00000268638-D1 Bos grunniens ENSP00000268638-D1 I 0.797
IRF8 Tupaia belangeri ENSTBEG00000013828 I 0.797
IRF8 Anolis carolinensis ENSACAG00000005409 I 0.797
ENSONIG00000005631 Oreochromis niloticus ENSONIG00000005631 I 0.797
ENSPPYG00000007620 Pongo abelii ENSPPYG00000007620 I 0.797
IRF8 Otolemur garnettii ENSOGAG00000009262 I 0.797
ENSNLEG00000011429 Nomascus leucogenys ENSNLEG00000011429 I 0.797
ENSOARG00000011513 Ovis aries ENSOARG00000011513 I 0.797
IRF8 Ornithorhynchus anatinus ENSOANG00000003741 I 0.797
ENSPANG00000024770 Papio anubis ENSPANG00000024770 I 0.797
ENSCSAG00000003142 Chlorocebus sabaeus ENSCSAG00000003142 I 0.797
irf8.L Xenopus laevis XB-GENE-985949 I 0.797
Irf8 Rattus norvegicus ENSRNOG00000017869 I 0.797
ENSCAFG00000007099 Canis familiaris ENSCAFG00000007099 I 0.797
irf8 Danio rerio ENSDARG00000056407 I 0.797
IRF8 Callithrix jacchus ENSCJAG00000017331 I 0.797
Irf8 Mus musculus ENSMUSG00000041515 D 0.797
IRF8 Pan troglodytes ENSPTRG00000008435 I 0.797
ENSAMEG00000013647 Ailuropoda melanoleuca ENSAMEG00000013647 I 0.780
irf8 Gasterosteus aculeatus ENSGACG00000015958 I 0.780
IRF8 Erinaceus europaeus ENSEEUG00000002644 I 0.780
ENSLOCG00000003532 Lepisosteus oculatus ENSLOCG00000003532 I 0.780
ENSTGUG00000006609 Taeniopygia guttata ENSTGUG00000006609 I 0.780
irf8 Tetraodon nigroviridis ENSTNIG00000009283 I 0.780
ENSFALG00000005506 Ficedula albicollis ENSFALG00000005506 I 0.780
ENSBTAP00000012124-D1 Bos grunniens ENSBTAP00000012124-D1 N 0.763
ENSAMXG00000002697 Astyanax mexicanus ENSAMXG00000002697 I 0.763
XP_002934991 Xenopus tropicalis XP_002934991 I 0.763
IRF8 Tursiops truncatus ENSTTRG00000016024 I 0.763
ENSBTAG00000031214 Bos taurus ENSBTAG00000031214 N 0.763
ENSGALG00000006448 Gallus gallus ENSGALG00000006448 I 0.763
ENSLACG00000007228 Latimeria chalumnae ENSLACG00000007228 I 0.763
ENSLACG00000004633 Latimeria chalumnae ENSLACG00000004633 I 0.763
ENSMPUG00000017895 Mustela putorius furo ENSMPUG00000017895 N 0.763
IRF8 Equus caballus ENSECAG00000015449 I 0.763
ENSOARG00000001815 Ovis aries ENSOARG00000001815 N 0.763
irf10 Tetraodon nigroviridis ENSTNIG00000012613 I 0.763
Afo_R010468 Aptenodytes forsteri Afo_R010468 I 0.754
Myotis_brandtii_IRF4_10023767 Myotis brandtii Myotis_brandtii_IRF4_10023767 N 0.746
irf10 Gasterosteus aculeatus ENSGACG00000015123 I 0.746
irf10 Takifugu rubripes ENSTRUG00000002917 I 0.746
ENSSTOG00000027141 Ictidomys tridecemlineatus ENSSTOG00000027141 N 0.746
ENSSSCG00000022547 Sus scrofa ENSSSCG00000022547 I 0.746
Alligator_sinensis_CCG000346.1 Alligator sinensis Alligator_sinensis_CCG000346.1 N 0.746
ENSDNOG00000030863 Dasypus novemcinctus ENSDNOG00000030863 N 0.729
irf10 Oryzias latipes ENSORLG00000011745 N 0.729
Gfo_R005312 Geospiza fortis Gfo_R005312 I 0.729
ENSPFOG00000009490 Poecilia formosa ENSPFOG00000009490 N 0.712
ENSMODG00000019483 Monodelphis domestica ENSMODG00000019483 I 0.712
Aan_R015695 Calypte anna Aan_R015695 I 0.712
ENSXMAG00000017848 Xiphophorus maculatus ENSXMAG00000017848 N 0.712
Ogr04948 Ophisaurus gracilis Ogr04948 N 0.712
Ogr08841 Ophisaurus gracilis Ogr08841 I 0.712