fgenesh_masked-pve_contig_141-abinit-gene-0.66 (Pythium vexans)
MADF,Storekeeper

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF10545 (MADF_DNA_bdg)
PF04504 (DUF573)
IPR006578
IPR007592
fgenesh_masked-pve_contig_141-abinit-gene-0.66 T252676_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
EPrPV00000016449 MADF 54 123
EPrPV00000016449 Storekeeper 206 280
EPrPV00000016449 Storekeeper 354 428

Links

Other MADF,Storekeeper family TFs
Other Pythium vexans TFs

0 Related TFs

">No related TF found