MEF2A (Homo sapiens)
MADS box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00319 (SRF-TF) IPR002100 ENSG00000068305 T253655_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MEF2A
M03340_2.00
Homo sapiens
KCTAWAAATAGM

KCTATTTWTAGM
SELEX
Jolma et al.(2013)
MEF2A_1
(Direct) (Direct)
MEF2A
M07979_2.00
Homo sapiens
NDDHYAAAAATARHH

DDYTATTTTTRDHHN
ChIP-seq
Gerstein et al.(2012)
GM12878_MEF2A_HudsonAlpha
(Direct) (Direct)
MEF2A
M08212_2.00
Homo sapiens
CTAWWWWTAG

CTAWWWWTAG
ChIP-seq
Contrino et al.(2012)
Mv88
(Direct) (Direct)
MEF2A
M08213_2.00
Homo sapiens
AAAATAGM

KCTATTTT
ChIP-seq
Contrino et al.(2012)
Mv90
(Direct) (Direct)
MEF2A
M09247_2.00
Homo sapiens
DYYAAAAATAGMH

DKCTATTTTTRRH
Misc
Kulakovskiy et al.(2013)
MEF2A_HUMAN.H11MO.0.A
(Direct) (Direct)
MEF2A
M10933_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AMEF2_Q6
(Direct) (Direct)
MEF2A
M10934_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HMEF2_Q6
(Direct) (Direct)
MEF2A
M10935_2.00
Homo sapiens
BTCTAAAAATAACYCY

RGRGTTATTTTTAGAV
Transfac
Matys et al.(2006)
V$MEF2_01
(Direct) (Direct)
MEF2A
M10936_2.00
Homo sapiens
BNNNDDDCTAWAAATAGMHNNN

NNNDKCTATTTWTAGHHHNNNV
Transfac
Matys et al.(2006)
V$MEF2_02
(Direct) (Direct)
MEF2A
M10937_2.00
Homo sapiens
NNNNDWKCTAWAAATAGMHHNN

NNDDKCTATTTWTAGMWHNNNN
Transfac
Matys et al.(2006)
V$MEF2_03
(Direct) (Direct)
MEF2A
M10938_2.00
Homo sapiens
NVTGTTRCTAWAAATAGAAHHN

NDDWTCTATTTWTAGYAACABN
Transfac
Matys et al.(2006)
V$MEF2_04
(Direct) (Direct)
MEF2A
M10939_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2A_05
(Direct) (Direct)
MEF2A
M10940_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2A_Q6
(Direct) (Direct)
MEF2A
M10941_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2_Q6_02
(Direct) (Direct)
MEF2A
M10942_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MMEF2_Q6
(Direct) (Direct)
MEF2A
M10943_2.00
Homo sapiens
NDKCTAWAAATAGMHH

DDKCTATTTWTAGMHN
Transfac
Matys et al.(2006)
V$RSRFC4_01
(Direct) (Direct)
MEF2A
M10944_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RSRFC4_Q2
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MEF2C
M02745_2.00
Homo sapiens
TWCTAWAAATAG

CTATTTWTAGWA
SELEX
Jolma et al.(2010)
MEF2C_dimer
1.000 1.000
MEF2C
M05551_2.00
Homo sapiens
CYWWATWWGG

CCWWATWWRG
SELEX
Yin et al.(2017)
MEF2C_FL_HT-SELEX
1.000 1.000
MEF2C
M08149_2.00
Homo sapiens
NDDMYAAAAATAGMH

DKCTATTTTTRKHHN
ChIP-seq
Mathelier et al.(2014)
MA0497.1
1.000 1.000
Mef2a
M09255_2.00
Mus musculus
DDCYAWAAATARMH

DKYTATTTWTRGHH
Misc
Kulakovskiy et al.(2013)
MEF2A_MOUSE.H11MO.0.A
1.000 1.000
MEF2C
M07980_2.00
Homo sapiens
NDDYYAAAAATAGHH

DDCTATTTTTRRHHN
ChIP-seq
Gerstein et al.(2012)
GM12878_MEF2C_HudsonAlpha
1.000 1.000
Mef2a
M09599_2.00
Mus musculus
CYNDAAATAG

CTATTTHNRG
Misc
Heinz et al.(2010)
HL1-Mef2a.biotin_GSE21529
1.000 1.000
MEF2C
M09248_2.00
Homo sapiens
DYYAAAAATARMH

DKYTATTTTTRRH
Misc
Kulakovskiy et al.(2013)
MEF2C_HUMAN.H11MO.0.A
1.000 1.000
Mef2c
M09253_2.00
Mus musculus
DDMYAAAAATAGMHN

NDKCTATTTTTRKHH
Misc
Kulakovskiy et al.(2013)
MEF2C_MOUSE.H11MO.0.A
1.000 1.000
MEF2C
M09597_2.00
Homo sapiens
DHYWDAAATARM

KYTATTTHWRDH
Misc
Heinz et al.(2010)
GM12878-Mef2c_GSE32465
1.000 1.000
MEF2C
M10945_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2C_02
1.000 1.000
MEF2C
M10946_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2C_Q4
1.000 1.000
MEF2C
M05552_2.00
Homo sapiens
CYWWATWWGG

CCWWATWWRG
SELEX
Yin et al.(2017)
MEF2C_FL_Methyl-HT-SELEX
1.000 1.000
MEF2D
M03343_2.00
Homo sapiens
DCTAWAAATAGM

KCTATTTWTAGH
SELEX
Jolma et al.(2013)
MEF2D_1
0.958 0.958
MEF2D
M05555_2.00
Homo sapiens
CYWWATWWGG

CCWWATWWRG
SELEX
Yin et al.(2017)
MEF2D_eDBD_HT-SELEX
0.958 0.958
MEF2D
M09250_2.00
Homo sapiens
CTAWAAATAGMH

DKCTATTTWTAG
Misc
Kulakovskiy et al.(2013)
MEF2D_HUMAN.H11MO.0.A
0.958 0.958
Mef2d
M09252_2.00
Mus musculus
DDCTAWAAATAGMH

DKCTATTTWTAGHH
Misc
Kulakovskiy et al.(2013)
MEF2D_MOUSE.H11MO.0.A
0.958 0.958
MEF2D
M10957_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2D_Q4
0.958 0.958
MEF2D
M05556_2.00
Homo sapiens
CYWWATWWGG

CCWWATWWRG
SELEX
Yin et al.(2017)
MEF2D_eDBD_Methyl-HT-SELEX
0.958 0.958
MEF2B
M03344_2.00
Homo sapiens
RCTAWAAATAGM

KCTATTTWTAGY
SELEX
Jolma et al.(2013)
MEF2B_1
0.931 0.931
MEF2B
M05557_2.00
Homo sapiens
CYNDWWWHGG

CCDWWWHNRG
SELEX
Yin et al.(2017)
MEF2B_eDBD_HT-SELEX
0.931 0.931
MEF2B
M05559_2.00
Homo sapiens
CCVDWTATGGTAACA

TGTTACCATAWHBGG
SELEX
Yin et al.(2017)
MEF2B_FL_HT-SELEX
0.917 0.917
MEF2B
M09251_2.00
Homo sapiens
CYWAAAATAGHHHH

DDDDCTATTTTWRG
Misc
Kulakovskiy et al.(2013)
MEF2B_HUMAN.H11MO.0.A
0.917 0.917
MEF2B
M05558_2.00
Homo sapiens
CYWWWWWNGG

CCNWWWWWRG
SELEX
Yin et al.(2017)
MEF2B_eDBD_Methyl-HT-SELEX
0.917 0.917
Mef2b
M10958_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEF2B_02
0.931 0.931
MEF2B
M05560_2.00
Homo sapiens
CCVDATATGGTAACR

YGTTACCATATHBGG
SELEX
Yin et al.(2017)
MEF2B_FL_Methyl-HT-SELEX
0.917 0.917
Mef2
M08214_2.00
Drosophila melanogaster
YTAWWWWTAR

YTAWWWWTAR
ChIP-seq
Contrino et al.(2012)
Mf26
0.896 0.896
RLM1
M08590_2.00
Saccharomyces cerevisiae
NTAWWWWTAG

CTAWWWWTAN
Misc
DeBoer et al.(2011)
YPL089C_419
0.759 0.759
RLM1
M08459_2.00
Saccharomyces cerevisiae
NDWTCTAWWWATAGMYHN

NDRKCTATWWWTAGAWHN
COMPILED
Mathelier et al.(2014)
MA0369.1
0.759 0.759
SMP1
M01557_2.00
Saccharomyces cerevisiae
TTAATAAA

TTTATTAA
PBM
Zhu et al.(2009)
Smp1
0.724 0.724
AGL13
M06989_2.00
Arabidopsis thaliana
WTWCYHAAAAWRGWAADW

WHTTWCYWTTTTDRGWAW
Dap-seq
OMalley et al.(2016)
AGL13_col_b
0.724 0.724
AGL6
M06986_2.00
Arabidopsis thaliana
TTWCCHAAAAWRGWAANWW

WWNTTWCYWTTTTDGGWAA
Dap-seq
OMalley et al.(2016)
AGL6_col_a
0.724 0.724
AGL3
M02693_2.00
Arabidopsis thaliana
VDWNCCAWWWWWRGNWNN

NNWNCYWWWWWTGGNWHB
SELEX
Mathelier et al.(2014)
MA0001.2
0.724 0.724
AGL1
M02694_2.00
Arabidopsis thaliana
NDTDCCWWWWNDGGWAHN

NDTWCCHNWWWWGGHAHN
SELEX
Mathelier et al.(2014)
MA0585.1
0.724 0.724
AG
M02695_2.00
Arabidopsis thaliana
HTTWCCWWAWNDGGHADN

NHTDCCHNWTWWGGWAAD
SELEX
Mathelier et al.(2014)
MA0005.2
0.724 0.724
SEP1
M02696_2.00
Arabidopsis thaliana
NDWNCCAWWWWTRGHAWB

VWTDCYAWWWWTGGNWHN
SELEX
Mathelier et al.(2014)
MA0584.1
0.724 0.724
SEP3
M08143_2.00
Arabidopsis thaliana
CCAAAAAWRGN

NCYWTTTTTGG
ChIP-seq
Mathelier et al.(2014)
MA0563.1
0.724 0.724
SMP1
M08587_2.00
Saccharomyces cerevisiae
BNDBMYWYAATTRWRNNWVNN

NNBWNNYWYAATTRWRKVHNV
Misc
DeBoer et al.(2011)
YBR182C_864
0.724 0.724
AG
M10923_2.00
Arabidopsis thaliana
HTTWCCWWAWNDGGHWDN

NHTDCCHNWTWWGGWAAD
Transfac
Matys et al.(2006)
P$AG_01
0.724 0.724
AG
M10924_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AG_02
0.724 0.724
AG
M10925_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AG_03
0.724 0.724
AG_TOBAC
M10995_2.00
Nicotiana tabacum Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AG1_02
0.724 0.724
AGL1
M10920_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL1_01
0.724 0.724
AGL1
M10921_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL1_02
0.724 0.724
SEP1
M10929_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL2_01
0.724 0.724
SEP1
M10930_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL2_02
0.724 0.724
AGL3
M10908_2.00
Arabidopsis thaliana
VDWNCCAWWWWWRGNWNN

NNWNCYWWWWWTGGNWHB
Transfac
Matys et al.(2006)
P$AGL3_01
0.724 0.724
AGL3
M10909_2.00
Arabidopsis thaliana
NDTNCCAWWWWTRGHWNN

NNWDCYAWWWWTGGNAHN
Transfac
Matys et al.(2006)
P$AGL3_02
0.724 0.724
AGL3
M10910_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL3_03
0.724 0.724
SEP2
M10916_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL4_01
0.724 0.724
SEP3
M10902_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AGL9_01
0.724 0.724
AG
M10926_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$AG_Q2
0.724 0.724
Q9LEH9_HORVU
M10983_2.00
Hordeum vulgare Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$BM9_01
0.724 0.724
Q40882_PETHY
M11003_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP11_01
0.724 0.724
AGL9_PETHY
M10993_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP2_01
0.724 0.724
Q9ATE7_PETHY
M11010_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP22_01
0.724 0.724
Q9ATE6_PETHY
M11009_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP23_01
0.724 0.724
Q9ATF3_PETHY
M11015_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP4_01
0.724 0.724
Q08711_PETHY
M10999_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP6_01
0.724 0.724
Q43616_PETHY
M11004_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP7_01
0.724 0.724
Q9ATF1_PETHY
M11013_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$FBP9_01
0.724 0.724
O82084_MALDO
M11018_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS1_01
0.724 0.724
O82699_MALDO
M11022_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS11_01
0.724 0.724
Q6UGQ8_PETHY
M11005_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS12_01
0.724 0.724
Q8VWZ3_MALDO
M11025_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS14_02
0.724 0.724
Q8VWZ2_MALDO
M11024_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS15_02
0.724 0.724
MAD17_ORYSJ
M10961_2.00
Oryza sativa Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS17_01
0.724 0.724
MADS3_ORYSJ
M10963_2.00
Oryza sativa Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS3_01
0.724 0.724
AG_PETHY
M10994_2.00
Petunia x hybrida Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS3_02
0.724 0.724
Q9ST54_MALDO
M11029_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS3_04
0.724 0.724
Q9LM09_TOBAC
M11016_2.00
Nicotiana tabacum Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS4_01
0.724 0.724
MADS6
M10967_2.00
Oryza sativa Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS6_01
0.724 0.724
O82697_MALDO
M11020_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS7_01
0.724 0.724
MADS7
M10975_2.00
Oryza sativa Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS7_02
0.724 0.724
MADS8
M10976_2.00
Oryza sativa Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS8_01
0.724 0.724
Q9SBA6_MALDO
M11028_2.00
Malus domestica Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$MADS8_02
0.724 0.724
SHP2
M10914_2.00
Arabidopsis thaliana Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$SHP2_01
0.724 0.724
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000337202 MADS box 10 57
ENSP00000346389 MADS box 10 57
ENSP00000452989 MADS box 10 57
ENSP00000453095 MADS box 10 57
ENSP00000453441 MADS box 10 57
ENSP00000453478 MADS box 10 57
ENSP00000454023 MADS box 10 38

Links

Other MADS box family TFs
Other Homo sapiens TFs

770 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action