MBD2 (Homo sapiens)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01429 (MBD) IPR001739 ENSG00000134046 T260164_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MBD2
M09256_2.00
Homo sapiens
VSGKCCGGMKR

YMKCCGGMCSB
Misc
Kulakovskiy et al.(2013)
MBD2_HUMAN.H11MO.0.B
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mbd2
M09258_2.00
Mus musculus
VSGKCCGGMKR

YMKCCGGMCSB
Misc
Kulakovskiy et al.(2013)
MBD2_MOUSE.H11MO.0.B
0.982 0.982
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000256429 MBD 146 216
ENSP00000256429 MBD 226 290
ENSP00000381435 MBD 146 216
ENSP00000464554 MBD 146 216

Links

Other MBD family TFs
Other Homo sapiens TFs

66 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSMMUG00000003136 Macaca mulatta ENSMMUG00000003136 I 1.000
MBD2 Loxodonta africana ENSLAFG00000014135 I 1.000
MBD2 Gorilla gorilla ENSGGOG00000013402 I 1.000
MBD2 Monodelphis domestica ENSMODG00000011041 I 1.000
ENSPANG00000021858 Papio anubis ENSPANG00000021858 I 1.000
ENSSTOG00000011253 Ictidomys tridecemlineatus ENSSTOG00000011253 I 1.000
MBD2 Sus scrofa ENSSSCG00000004528 I 1.000
MBD2 Pan troglodytes ENSPTRG00000010033 I 1.000
MBD2 Dasypus novemcinctus ENSDNOG00000033421 I 1.000
MBD2 Oryctolagus cuniculus ENSOCUG00000021080 I 1.000
ENSAMEG00000017208 Ailuropoda melanoleuca ENSAMEG00000017208 I 1.000
MBD2 Cavia porcellus ENSCPOG00000006832 I 0.991
ENSECAG00000022368 Equus caballus ENSECAG00000022368 I 0.991
Mbd2 Mus musculus ENSMUSG00000024513 D 0.986
MBD2 Tursiops truncatus ENSTTRG00000009635 N 0.986
MBD2 Tupaia belangeri ENSTBEG00000015292 I 0.982
MBD2 Callithrix jacchus ENSCJAG00000001862 I 0.982
Mbd2 Rattus norvegicus ENSRNOG00000011853 I 0.982
MBD2 Otolemur garnettii ENSOGAG00000008028 I 0.982
ENSCSAG00000018106 Chlorocebus sabaeus ENSCSAG00000018106 I 0.955
Ogr03458 Ophisaurus gracilis Ogr03458 I 0.955
ENSLACG00000016038 Latimeria chalumnae ENSLACG00000016038 I 0.946
ENSACAG00000008739 Anolis carolinensis ENSACAG00000008739 I 0.946
MBD2 Pteropus vampyrus ENSPVAG00000008555 N 0.944
ENSCHOG00000012250 Choloepus hoffmanni ENSCHOG00000012250 N 0.943
ENSLOCG00000003370 Lepisosteus oculatus ENSLOCG00000003370 I 0.892
ENSP00000256429-D1 Bos grunniens ENSP00000256429-D1 I 0.892
mbd2.S Xenopus laevis XB-GENE-493780 I 0.865
ENSONIG00000012635 Oreochromis niloticus ENSONIG00000012635 I 0.865
ENSXMAG00000003932 Xiphophorus maculatus ENSXMAG00000003932 I 0.856
MBD3 Oryzias latipes ENSORLG00000004850 N 0.845
ENSGACG00000018294 Gasterosteus aculeatus ENSGACG00000018294 I 0.838
ENSTNIG00000003709 Tetraodon nigroviridis ENSTNIG00000003709 I 0.838
MBD3 Tetraodon nigroviridis ENSTNIG00000010627 N 0.829
ENSTRUG00000006522 Takifugu rubripes ENSTRUG00000006522 I 0.829
ENSAMXG00000017952 Astyanax mexicanus ENSAMXG00000017952 I 0.817
Ogr00377 Ophisaurus gracilis Ogr00377 N 0.803
ENSLACG00000016498 Latimeria chalumnae ENSLACG00000016498 N 0.802
mbd3a Danio rerio ENSDARG00000061774 I 0.802
ENSAMEG00000003491 Ailuropoda melanoleuca ENSAMEG00000003491 I 0.795
Pvit_09821 Pogona vitticeps Pvit_09821 N 0.793
mbd3 Xenopus tropicalis XB-GENE-491553 I 0.793
mbd3.S Xenopus laevis XB-GENE-491557 I 0.793
ENSPFOG00000003939 Poecilia formosa ENSPFOG00000003939 I 0.793
mbd2 Danio rerio ENSDARG00000075952 I 0.784
MBD2 Myotis lucifugus ENSMLUG00000009980 I 0.775
estExt_fgenesh2_pg.C_2010088 Branchiostoma floridae estExt_fgenesh2_pg.C_2010088 N 0.757
ENSXMAG00000012716 Xiphophorus maculatus ENSXMAG00000012716 I 0.750
MBD3 Tursiops truncatus ENSTTRG00000004412 N 0.748
MBD3 Pteropus vampyrus ENSPVAG00000017085 I 0.748
Mbd3 Mus musculus ENSMUSG00000035478 N 0.739
MBD3 Macaca mulatta ENSMMUG00000009014 N 0.732
MBD3 Homo sapiens ENSG00000071655 N 0.732
ENSNLEG00000001734 Nomascus leucogenys ENSNLEG00000001734 N 0.732
MBD3 Pan troglodytes ENSPTRG00000010209 N 0.732
ENSPANG00000015324 Papio anubis ENSPANG00000015324 N 0.732
MBD3 Cavia porcellus ENSCPOG00000026210 N 0.732
ENSCSAG00000011976 Chlorocebus sabaeus ENSCSAG00000011976 N 0.732
SMAR015035 Strigamia maritima SMAR015035 N 0.730
MBD3 Otolemur garnettii ENSOGAG00000024563 N 0.718
Mbd3 Dipodomys ordii ENSDORG00000004743 N 0.718
Cmyd_10012649 Chelonia mydas Cmyd_10012649 I 0.705
ENSSTOG00000015870 Ictidomys tridecemlineatus ENSSTOG00000015870 N 0.704
ENSAMXG00000006553 Astyanax mexicanus ENSAMXG00000006553 N 0.703
ENSOARG00000004770 Ovis aries ENSOARG00000004770 I 0.703