SETDB1 (Homo sapiens)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01429 (MBD) IPR001739 ENSG00000143379 T260166_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SETDB1
M11031_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SETDB1_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000271640 MBD 594 668
ENSP00000357965 MBD 594 668
ENSP00000432348 MBD 594 668
ENSP00000436148 MBD 595 636

Links

Other MBD family TFs
Other Homo sapiens TFs

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67 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action