Mecp2 (Rattus norvegicus)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01429 (MBD) IPR001739 ENSRNOG00000056659 T260412_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA binding activity; histone deacetylase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including nervous system development; positive regulation of dense core granule transport; and regulation of dendrite extension. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study Rett syndrome. Biomarker of hepatocellular carcinoma; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability Lubs type. Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mecp2
M00806_2.00 		Mus musculus
NNNNNHAHNN
NNDTDNNNNN		 PBM
Weirauch et al.(2013)
pTH3054 		1.000 1.000
MECP2
M09257_2.00 		Homo sapiens
SCCGGRR
YYCCGGS		 Misc
Kulakovskiy et al.(2013)
MECP2_HUMAN.H11MO.0.C 		1.000 1.000
Mecp2
M09259_2.00 		Mus musculus
SCCGGRR
YYCCGGS		 Misc
Kulakovskiy et al.(2013)
MECP2_MOUSE.H11MO.0.C 		1.000 1.000
MECP2
M11032_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MECP2_01 		1.000 1.000
MECP2
M11033_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MECP2_02 		1.000 1.000
MECP2
M11034_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MECP2_Q4_01 		1.000 1.000
MECP2
M11035_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MECP2_Q4 		1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000069913 MBD 91 162

Links

Other MBD family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

57 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action