ENSP00000256429 (Macaca fascicularis)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF01429 (MBD) IPR001739 ENSP00000256429 T261268_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MBD2
M09256_2.00
Homo sapiens
VSGKCCGGMKR

YMKCCGGMCSB
Misc
Kulakovskiy et al.(2013)
MBD2_HUMAN.H11MO.0.B
0.817 0.817
Mbd2
M09258_2.00
Mus musculus
VSGKCCGGMKR

YMKCCGGMCSB
Misc
Kulakovskiy et al.(2013)
MBD2_MOUSE.H11MO.0.B
0.796 0.796
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000256429 MBD 1 37
ENSP00000256429 MBD 44 111

Links

Other MBD family TFs
Other Macaca fascicularis TFs

35 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSTSYG00000013361 Tarsius syrichta ENSTSYG00000013361 I 1.000
ENSP00000256429-D1 Bos grunniens ENSP00000256429-D1 I 1.000
ENSOARG00000004770 Ovis aries ENSOARG00000004770 I 1.000
MBD2 Microcebus murinus ENSMICG00000008970 I 1.000
ENSFCAG00000022047 Felis catus ENSFCAG00000022047 I 0.989
ENSLACG00000016038 Latimeria chalumnae ENSLACG00000016038 I 0.989
ENSMEUG00000016480 Macropus eugenii ENSMEUG00000016480 I 0.978
Pvit_04402 Pogona vitticeps Pvit_04402 I 0.957
Afo_R000663 Aptenodytes forsteri Afo_R000663 I 0.957
ENSAPLG00000010058 Anas platyrhynchos ENSAPLG00000010058 I 0.938
ENSVPAG00000012298 Vicugna pacos ENSVPAG00000012298 N 0.900
ENSLOCG00000003370 Lepisosteus oculatus ENSLOCG00000003370 I 0.882
Cmyd_10012649 Chelonia mydas Cmyd_10012649 I 0.874
MBD3 Gasterosteus aculeatus ENSGACG00000012755 I 0.827
MBD2 Callithrix jacchus ENSCJAG00000001862 I 0.817
MBD2 Tupaia belangeri ENSTBEG00000015292 I 0.806
ENSAMXG00000017952 Astyanax mexicanus ENSAMXG00000017952 I 0.805
mbd3a Danio rerio ENSDARG00000061774 I 0.805
MBD3 Tetraodon nigroviridis ENSTNIG00000010627 N 0.796
ENSAMEG00000003491 Ailuropoda melanoleuca ENSAMEG00000003491 I 0.795
ENSONIG00000012635 Oreochromis niloticus ENSONIG00000012635 I 0.785
Mbd3 Mus musculus ENSMUSG00000035478 N 0.764
ENSCSAG00000018106 Chlorocebus sabaeus ENSCSAG00000018106 I 0.756
ENSMGAG00000009222 Meleagris gallopavo ENSMGAG00000009222 N 0.753
ENSXMAG00000012716 Xiphophorus maculatus ENSXMAG00000012716 I 0.750
ENSGMOG00000008953 Gadus morhua ENSGMOG00000008953 I 0.741
MBD3 Equus caballus ENSECAG00000015485 I 0.738
ENSECAG00000022368 Equus caballus ENSECAG00000022368 I 0.732
MBD3 Ochotona princeps ENSOPRG00000008719 I 0.729
MBD2 Cavia porcellus ENSCPOG00000006832 I 0.724
ENSOANG00000030623 Ornithorhynchus anatinus ENSOANG00000030623 I 0.710
ENSXMAG00000003932 Xiphophorus maculatus ENSXMAG00000003932 I 0.710
ENSPMAG00000000415 Petromyzon marinus ENSPMAG00000000415 N 0.710
ENSPPYG00000009325 Pongo abelii ENSPPYG00000009325 I 0.709
MBD3 Canis familiaris ENSCAFG00000019503 N 0.708