ENSP00000395535 (Macaca fascicularis)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF01429 (MBD) IPR001739 ENSP00000395535 T261274_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mecp2
M00806_2.00
Mus musculus
NNNNNHAHNN

NNDTDNNNNN
PBM
Weirauch et al.(2013)
pTH3054
1.000 1.000
MECP2
M09257_2.00
Homo sapiens
SCCGGRR

YYCCGGS
Misc
Kulakovskiy et al.(2013)
MECP2_HUMAN.H11MO.0.C
1.000 1.000
Mecp2
M09259_2.00
Mus musculus
SCCGGRR

YYCCGGS
Misc
Kulakovskiy et al.(2013)
MECP2_MOUSE.H11MO.0.C
1.000 1.000
MECP2
M11032_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MECP2_01
1.000 1.000
MECP2
M11033_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MECP2_02
1.000 1.000
MECP2
M11034_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MECP2_Q4_01
1.000 1.000
MECP2
M11035_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MECP2_Q4
1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000395535 MBD 82 153

Links

Other MBD family TFs
Other Macaca fascicularis TFs

57 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
MECP2 Otolemur garnettii ENSOGAG00000015115 I 1.000
ENSPANG00000011691 Papio anubis ENSPANG00000011691 I 1.000
ENSPSIG00000002254 Pelodiscus sinensis ENSPSIG00000002254 I 1.000
MECP2 Pan troglodytes ENSPTRG00000022424 I 1.000
MECP2 Oryctolagus cuniculus ENSOCUG00000013147 I 1.000
ENSOARG00000005806 Ovis aries ENSOARG00000005806 I 1.000
MECP2 Macaca mulatta ENSMMUG00000018704 I 1.000
MECP2 Monodelphis domestica ENSMODG00000011643 I 1.000
ENSMPUG00000009072 Mustela putorius furo ENSMPUG00000009072 I 1.000
Mecp2 Mus musculus ENSMUSG00000031393 D 1.000
Mecp2 Rattus norvegicus ENSRNOG00000056659 I 1.000
MECP2 Sorex araneus ENSSARG00000012925 I 1.000
ENSP00000395535-D1 Bos grunniens ENSP00000395535-D1 I 1.000
Myotis_brandtii_IRAK1_10010673 Myotis brandtii Myotis_brandtii_IRAK1_10010673 I 1.000
Ogr09995 Ophisaurus gracilis Ogr09995 I 1.000
Pvit_16673 Pogona vitticeps Pvit_16673 I 1.000
MECP2 Tursiops truncatus ENSTTRG00000004653 I 1.000
ENSTSYG00000007420 Tarsius syrichta ENSTSYG00000007420 I 1.000
ENSSHAG00000007851 Sarcophilus harrisii ENSSHAG00000007851 I 1.000
ENSSSCG00000012796 Sus scrofa ENSSSCG00000012796 I 1.000
ENSSTOG00000006094 Ictidomys tridecemlineatus ENSSTOG00000006094 I 1.000
MECP2 Myotis lucifugus ENSMLUG00000014297 I 1.000
MECP2 Ornithorhynchus anatinus ENSOANG00000011024 I 1.000
MECP2 Dasypus novemcinctus ENSDNOG00000013419 I 1.000
Mecp2 Dipodomys ordii ENSDORG00000014978 I 1.000
MECP2 Equus caballus ENSECAG00000018208 I 1.000
MECP2 Microcebus murinus ENSMICG00000005149 I 1.000
ENSCSAG00000006798 Chlorocebus sabaeus ENSCSAG00000006798 I 1.000
MECP2 Cavia porcellus ENSCPOG00000012579 I 1.000
ENSAMEG00000018448 Ailuropoda melanoleuca ENSAMEG00000018448 I 1.000
MECP2 Bos taurus ENSBTAG00000047855 I 1.000
MECP2 Canis familiaris ENSCAFG00000019440 I 1.000
MECP2 Callithrix jacchus ENSCJAG00000016796 I 1.000
MECP2 Felis catus ENSFCAG00000011389 I 1.000
ENSEEUG00000015025 Erinaceus europaeus ENSEEUG00000015025 I 1.000
ENSMEUG00000002761 Macropus eugenii ENSMEUG00000002761 I 1.000
MECP2 Gorilla gorilla ENSGGOG00000000222 I 1.000
MECP2 Homo sapiens ENSG00000169057 D 1.000
MECP2 Anolis carolinensis ENSACAG00000012519 I 0.986
ENSLACG00000011281 Latimeria chalumnae ENSLACG00000011281 I 0.958
MECP2 Loxodonta africana ENSLAFG00000016292 I 0.942
MECP2 Procavia capensis ENSPCAG00000011826 I 0.931
mecp2 Xenopus tropicalis XB-GENE-494740 I 0.917
mecp2.S Xenopus laevis XB-GENE-494744 I 0.917
ENSXMAG00000003522 Xiphophorus maculatus ENSXMAG00000003522 I 0.889
ENSPFOG00000002307 Poecilia formosa ENSPFOG00000002307 I 0.889
Cmyd_10000498 Chelonia mydas Cmyd_10000498 I 0.889
ENSLOCG00000014725 Lepisosteus oculatus ENSLOCG00000014725 I 0.889
ENSAMXG00000017019 Astyanax mexicanus ENSAMXG00000017019 I 0.887
mecp2 Tetraodon nigroviridis ENSTNIG00000005114 I 0.875
mecp2 Takifugu rubripes ENSTRUG00000006419 I 0.875
ENSONIG00000000809 Oreochromis niloticus ENSONIG00000000809 I 0.875
mecp2 Gasterosteus aculeatus ENSGACG00000000798 I 0.873
mecp2 Danio rerio ENSDARG00000014218 I 0.871
ENSNLEG00000013783 Nomascus leucogenys ENSNLEG00000013783 I 0.861
ENSPPYG00000020866 Pongo abelii ENSPPYG00000020866 I 0.861
mecp2 Oryzias latipes ENSORLG00000020117 I 0.847