DMTF1 (Homo sapiens)
Myb/SANT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00249 (Myb_DNA-binding) IPR014778 ENSG00000135164 T269580_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000332171 Myb 224 268
ENSP00000332171 Myb 273 329
ENSP00000378193 Myb 224 268
ENSP00000378193 Myb 273 329
ENSP00000402627 Myb 224 268
ENSP00000402627 Myb 273 329
ENSP00000412532 Myb 136 180
ENSP00000412532 Myb 185 241
ENSP00000448775 Myb 153 173
ENSP00000448775 Myb 224 268
ENSP00000448775 Myb 273 329
ENSP00000463638 Myb 112 132
ENSP00000463638 Myb 183 227
ENSP00000463638 Myb 232 288

Links

Other Myb/SANT family TFs
Other Homo sapiens TFs

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70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action