CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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DMTF1
(
Homo sapiens
)
Myb/SANT
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00249 (Myb_DNA-binding)
IPR014778
ENSG00000135164
T269580_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No TFs with similar DNA binding domains
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000332171
Myb
224
268
VGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMK
ENSP00000332171
Myb
273
329
TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL
ENSP00000378193
Myb
224
268
VGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMK
ENSP00000378193
Myb
273
329
TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL
ENSP00000402627
Myb
224
268
VGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMK
ENSP00000402627
Myb
273
329
TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL
ENSP00000412532
Myb
136
180
VGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMK
ENSP00000412532
Myb
185
241
TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL
ENSP00000448775
Myb
153
173
QGMWSKEEIDILMNNIERYLK
ENSP00000448775
Myb
224
268
VGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMK
ENSP00000448775
Myb
273
329
TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL
ENSP00000463638
Myb
112
132
QGMWSKEEIDILMNNIERYLK
ENSP00000463638
Myb
183
227
VGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMK
ENSP00000463638
Myb
232
288
TGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL
Links
Other
Myb/SANT
family TFs
Other
Homo sapiens
TFs
70 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy