Mybl2 (Mus musculus)
Myb/SANT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00249 (Myb_DNA-binding) IPR014778 ENSMUSG00000017861 T269781_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mybl2
M00807_2.00		 Mus musculus
HAACSGHYN
NRDCSGTTD		 PBM
Weirauch et al.(2013)
pTH3712		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MYBL2
M03345_2.00 		Homo sapiens
RDMSGTTAACSGTT
AACSGTTAACSKHY		 SELEX
Jolma et al.(2013)
MYBL2_1 		0.909 1.000
MYBL2
M03346_2.00 		Homo sapiens
RCCGTTAVRACCGTTA
TAACGGTYBTAACGGY		 SELEX
Jolma et al.(2013)
MYBL2_2 		0.909 1.000
MYBL2
M03347_2.00 		Homo sapiens
NNRACCGTTWN
NWAACGGTYNN		 SELEX
Jolma et al.(2013)
MYBL2_3 		0.909 1.000
MYBL2
M03348_2.00 		Homo sapiens
RDCCGTTWAACBGHY
RDCVGTTWAACGGHY		 SELEX
Jolma et al.(2013)
MYBL2_4 		0.909 1.000
MYBL2
M05561_2.00 		Homo sapiens
NWAACSGTYDN
NHRACSGTTWN		 SELEX
Yin et al.(2017)
MYBL2_eDBD_HT-SELEX 		0.909 1.000
MYBL2
M09600_2.00 		Homo sapiens
NHAACNGHYN
NRDCNGTTDN		 Misc
Heinz et al.(2010)
Hela-BMYB_GSE27030 		0.909 1.000
MYBL2
M05562_2.00 		Homo sapiens
NHRACSGTYDN
NHRACSGTYDN		 SELEX
Yin et al.(2017)
MYBL2_eDBD_Methyl-HT-SELEX 		0.909 1.000
For this family, TFs with SR scores > 0.661 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00807_2.00 Myb 17 63
M00807_2.00 Myb 69 115
M00807_2.00 Myb 121 166

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000018005 Myb 31 77
ENSMUSP00000018005 Myb 83 129
ENSMUSP00000018005 Myb 135 180

Links

Other Myb/SANT family TFs
Other Mus musculus TFs

Invalid Input OrderBy

58 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action