NCBI Gene Info:Enables ATP-dependent chromatin remodeler activity; DNA binding activity; and methylated histone binding activity. Involved in several processes, including negative regulation of histone acetylation; nucleosome organization; and transcription, DNA-templated. Located in nucleolar chromatin. Part of SAGA complex and SLIK (SAGA-like) complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma; developmental and epileptic encephalopathy; and prostate cancer. Orthologous to several human genes including CHD1 (chromodomain helicase DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022] |