ENSP00000217026-D1 (Bos grunniens)
Myb/SANT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00249 (Myb_DNA-binding) IPR014778 ENSP00000217026-D1 T283367_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mybl2
M00807_2.00 		Mus musculus
HAACSGHYN
NRDCSGTTD		 PBM
Weirauch et al.(2013)
pTH3712 		0.898 0.986
MYBL2
M03345_2.00 		Homo sapiens
RDMSGTTAACSGTT
AACSGTTAACSKHY		 SELEX
Jolma et al.(2013)
MYBL2_1 		0.898 0.986
MYBL2
M03346_2.00 		Homo sapiens
RCCGTTAVRACCGTTA
TAACGGTYBTAACGGY		 SELEX
Jolma et al.(2013)
MYBL2_2 		0.898 0.986
MYBL2
M03347_2.00 		Homo sapiens
NNRACCGTTWN
NWAACGGTYNN		 SELEX
Jolma et al.(2013)
MYBL2_3 		0.898 0.986
MYBL2
M03348_2.00 		Homo sapiens
RDCCGTTWAACBGHY
RDCVGTTWAACGGHY		 SELEX
Jolma et al.(2013)
MYBL2_4 		0.898 0.986
MYBL2
M05561_2.00 		Homo sapiens
NWAACSGTYDN
NHRACSGTTWN		 SELEX
Yin et al.(2017)
MYBL2_eDBD_HT-SELEX 		0.898 0.986
MYBL2
M09600_2.00 		Homo sapiens
NHAACNGHYN
NRDCNGTTDN		 Misc
Heinz et al.(2010)
Hela-BMYB_GSE27030 		0.898 0.986
MYBL2
M05562_2.00 		Homo sapiens
NHRACSGTYDN
NHRACSGTYDN		 SELEX
Yin et al.(2017)
MYBL2_eDBD_Methyl-HT-SELEX 		0.898 0.986
For this family, TFs with SR scores > 0.661 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000217026-D1 Myb 35 81
ENSP00000217026-D1 Myb 87 133
ENSP00000217026-D1 Myb 139 184

Links

Other Myb/SANT family TFs
Other Bos grunniens TFs

Invalid Input OrderBy

59 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action