CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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AR
(
Homo sapiens
)
Nuclear receptor
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00105 (zf-C4)
IPR001628
ENSG00000169083
T303239_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
AR
M03389_2.00
Homo sapiens
DRGWACRHVDYGTWCCY
RGGWACRHBDYGTWCYH
SELEX
Jolma et al.(2013)
AR_1
(Direct)
(Direct)
AR
M03390_2.00
Homo sapiens
DRGWACAYNRTGTWCYY
RRGWACAYNRTGTWCYH
SELEX
Jolma et al.(2013)
AR_2
(Direct)
(Direct)
AR
M09288_2.00
Homo sapiens
DRYAAAYADNNNRGNACA
TGTNCYNNNHTRTTTRYH
Misc
Kulakovskiy et al.(2013)
ANDR_HUMAN.H11MO.0.A
(Direct)
(Direct)
AR
M09609_2.00
Homo sapiens
SHDRGVACAS
STGTBCYHDS
Misc
Heinz et al.(2010)
LNCaP-AR_GSE27824
(Direct)
(Direct)
AR
M09610_2.00
Homo sapiens
NRGNACABNVTGTNCY
RGNACABNVTGTNCYN
Misc
Heinz et al.(2010)
LNCAP-AR_GSE27824
(Direct)
(Direct)
AR
M11157_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_01
(Direct)
(Direct)
AR
M11158_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_02
(Direct)
(Direct)
AR
M11159_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_03
(Direct)
(Direct)
AR
M11160_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_04
(Direct)
(Direct)
AR
M11161_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_11
(Direct)
(Direct)
AR
M11162_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_13
(Direct)
(Direct)
AR
M11163_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_14_H
(Direct)
(Direct)
AR
M11164_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_Q2
(Direct)
(Direct)
AR
M11165_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_Q6_01
(Direct)
(Direct)
AR
M11166_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AR_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Ar
M00821_2.00
Mus musculus
NRRGAACAYN
NRTGTTCYYN
PBM
Weirauch et al.(2013)
pTH1739
0.992
1.000
Ar
M03436_2.00
Mus musculus
NRGHACAYNVYGTWCYN
NRGWACRBNRTGTDCYN
SELEX
Jolma et al.(2013)
Ar_1
0.992
1.000
Ar
M09331_2.00
Mus musculus
NRGNACABRVTGTNCY
RGNACABYVTGTNCYN
Misc
Kulakovskiy et al.(2013)
ANDR_MOUSE.H11MO.0.A
0.992
1.000
NR3C1
M03366_2.00
Homo sapiens
NRGWACAYNRTGTWCYH
DRGWACAYNRTGTWCYN
SELEX
Jolma et al.(2013)
NR3C1_1
0.978
0.786
NR3C1
M05587_2.00
Homo sapiens
RGDACAYWDTGTHCY
RGDACAHWRTGTHCY
SELEX
Yin et al.(2017)
NR3C1_eDBD_HT-SELEX
0.978
0.786
NR3C1
M07986_2.00
Homo sapiens
DGNACABYBTGTNC
GNACAVRVTGTNCH
ChIP-seq
Gerstein et al.(2012)
A549_GR_HudsonAlpha
0.978
0.786
NR3C1
M07987_2.00
Homo sapiens
NNNNRGNACAYBBTGTHCYNN
NNRGDACAVVRTGTNCYNNNN
ChIP-seq
Gerstein et al.(2012)
ECC-1_GR_HudsonAlpha
0.978
0.786
NR3C1
M09270_2.00
Homo sapiens
DGNACABKNTGTNCY
RGNACANMVTGTNCH
Misc
Kulakovskiy et al.(2013)
GCR_HUMAN.H11MO.0.A
0.978
0.786
NR3C1
M09607_2.00
Homo sapiens
NRGNACABNVTGTNCY
RGNACABNVTGTNCYN
Misc
Heinz et al.(2010)
A549-GR_GSE32465
0.978
0.786
NR3C1
M11119_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GR_01
0.978
0.786
NR3C1
M11120_2.00
Homo sapiens
KKYACMRDVTGTYCTK
MAGRACABHYKGTRMM
Transfac
Matys et al.(2006)
V$GRE_C
0.978
0.786
NR3C1
M11121_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GR_Q4
0.978
0.786
NR3C1
M11122_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GR_Q6_01
0.978
0.786
NR3C1
M11123_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GR_Q6_02
0.978
0.786
NR3C1
M11124_2.00
Homo sapiens
NNWGVACANWDNNDNBHNN
NNDVNHNNHWNTGTBCWNN
Transfac
Matys et al.(2006)
V$GR_Q6
0.978
0.786
NR3C1
M11125_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NR3C1_04
0.978
0.786
NR3C1
M05588_2.00
Homo sapiens
RGDACANDRYGTHCY
RGDACRYHNTGTHCY
SELEX
Yin et al.(2017)
NR3C1_eDBD_Methyl-HT-SELEX
0.978
0.786
PGR
M03923_2.00
Homo sapiens
DGNACANNNYGTNCY
RGNACRNNNTGTNCH
SELEX
Nitta et al.(2015)
PGR_1
0.977
0.800
PGR
M09266_2.00
Homo sapiens
RGNACWBYBTGTNCYN
NRGNACAVRVWGTNCY
Misc
Kulakovskiy et al.(2013)
PRGR_HUMAN.H11MO.0.A
0.977
0.800
Pgr
M09326_2.00
Mus musculus
RGNACWBYNTGTNCY
RGNACANRVWGTNCY
Misc
Kulakovskiy et al.(2013)
PRGR_MOUSE.H11MO.0.A
0.977
0.800
PGR
M09603_2.00
Homo sapiens
RNACWNNNWGTNCHN
NDGNACWNNNWGTNY
Misc
Heinz et al.(2010)
T47D-PR_GSE31130
0.977
0.800
PGR
M11095_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PR_01
0.977
0.800
PGR
M11096_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PR_02
0.977
0.800
PGR
M11097_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PR_Q6
0.977
0.800
NR3C2
M02395_2.00
Homo sapiens
NNRGDACAN
NTGTHCYNN
PBM
Weirauch et al.(2014)
pTH5924
0.974
0.771
NR3C2
M03382_2.00
Homo sapiens
NRGDACAHDRTGTHCYN
NRGDACAYHDTGTHCYN
SELEX
Jolma et al.(2013)
NR3C2_1
0.974
0.771
NR3C2
M05637_2.00
Homo sapiens
NGNACRNNNYGTNCN
NGNACRNNNYGTNCN
SELEX
Yin et al.(2017)
NR3C2_eDBD_HT-SELEX
0.974
0.771
NR3C2
M05638_2.00
Homo sapiens
NGNACRNNVYGTNCN
NGNACRBNNYGTNCN
SELEX
Yin et al.(2017)
NR3C2_eDBD_Methyl-HT-SELEX
0.974
0.771
Nr3c1
M05886_2.00
Mus musculus
DGDACDBYNTGTNCY
RGNACANRVHGTHCH
SMiLE-seq
Isakova et al.(2017)
GR
0.974
0.771
Nr3c1
M09318_2.00
Mus musculus
RGNACABYNTGTNCY
RGNACANRVTGTNCY
Misc
Kulakovskiy et al.(2013)
GCR_MOUSE.H11MO.0.A
0.974
0.771
Nr3c1
M09614_2.00
Mus musculus
NRGDACABNNTGTNC
GNACANNVTGTHCYN
Misc
Heinz et al.(2010)
RAW264.7-GRE_Unpublished
0.974
0.771
For this family, TFs with SR scores >
0.745
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000363822
Nuclear receptor
558
627
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTL
ENSP00000379358
Nuclear receptor
26
95
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTL
ENSP00000379359
Nuclear receptor
558
627
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTL
ENSP00000421155
Nuclear receptor
558
627
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTL
ENSP00000425199
Nuclear receptor
558
597
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGFFRMNKL
ENSP00000482407
Nuclear receptor
558
604
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGFFRMNKLKESSDTN
ENSP00000484033
Nuclear receptor
368
437
KTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTL
Links
Other
Nuclear receptor
family TFs
Other
Homo sapiens
TFs
272 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy