Hr96 (Drosophila melanogaster)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 FBgn0015240 T305282_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including lipid homeostasis; regulation of glycogen metabolic process; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic/larval Malpighian tubule; embryonic/larval digestive system; and embryonic/larval fat body. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to several human genes including NR1I2 (nuclear receptor subfamily 1 group I member 2) and VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hr96
M03940_2.00		 Drosophila melanogaster
YVRGTRCANVTGYACYBR
YVRGTRCABNTGYACYBR		 SELEX
Nitta et al.(2015)
Hr96_1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
daf-12
M00685_2.00 		Caenorhabditis elegans
NDAGTRCANN
NNTGYACTHN		 PBM
Narasimhan et al.(2015)
pTH9108 		0.929 0.686
daf-12
M08159_2.00 		Caenorhabditis elegans
GWGYGYGYKTGYDKB
VMHRCAMRCRCRCWC		 ChIP-seq
Mathelier et al.(2014)
MA0538.1 		0.929 0.686
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0084131 Nuclear receptor 5 74

Links

Other Nuclear receptor family TFs
Other Drosophila melanogaster TFs

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161 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action