fax-1 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00001400 T306124_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including neuron differentiation; regulation of backward locomotion; and regulation of forward locomotion. Located in nucleus. Is expressed in several structures, including anal region; hermaphrodite distal tip cell; neurons; rect_D; and vulva. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Orthologous to human NR2E3 (nuclear receptor subfamily 2 group E member 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hr51
M06432_2.00 		Drosophila melanogaster
AMRDATCARARGW
WCYTYTGATHYKT		 B1H
Zhu et al.(2011)
Hr51_SANGER_5_FBgn0034012 		0.980 0.900
GA30480
M02409_2.00 		Drosophila pseudoobscura
RAGATCAM
KTGATCTY		 PBM
Weirauch et al.(2014)
pTH5877 		0.980 0.886
NR2E3
M00373_2.00 		Homo sapiens
NRAGATCAMN
NKTGATCTYN		 PBM
Barrera et al.(2016)
NR2E3_REF 		0.968 0.843
Nr2e3
M02708_2.00 		Mus musculus
AAGCTTD
HAAGCTT		 SELEX
Mathelier et al.(2014)
MA0164.1 		0.968 0.843
Nr2e3
M09328_2.00 		Mus musculus
NAAGTCAAAARKCA
TGMYTTTTGACTTN		 Misc
Kulakovskiy et al.(2013)
NR2E3_MOUSE.H11MO.0.C 		0.968 0.843
NR2E3
M00372_2.00 		Homo sapiens
AAAGATCA
TGATCTTT		 PBM
Barrera et al.(2016)
NR2E3_R77Q 		0.968 0.829
NR2E3
M00370_2.00 		Homo sapiens
NNNWRABATCANN
NNTGATVTYWNNN		 PBM
Barrera et al.(2016)
NR2E3_R76Q 		0.963 0.829
NR2E3
M00371_2.00 		Homo sapiens
NNNHAATWTRTNN
NNAYAWATTDNNN		 PBM
Barrera et al.(2016)
NR2E3_R76W 		0.957 0.829
NR2E3
M00369_2.00 		Homo sapiens
NGGGRTCAHN
NDTGAYCCCN		 PBM
Barrera et al.(2016)
NR2E3_G56R 		0.950 0.829
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F56E3.4a Nuclear receptor 100 170
F56E3.4b Nuclear receptor 100 170

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

171 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action