nhr-8 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003607 T306132_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cholesterol homeostasis. Located in nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2); NR1I3 (nuclear receptor subfamily 1 group I member 3); and VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
daf-12
M00685_2.00 		Caenorhabditis elegans
NDAGTRCANN
NNTGYACTHN		 PBM
Narasimhan et al.(2015)
pTH9108 		0.759 0.657
daf-12
M08159_2.00 		Caenorhabditis elegans
GWGYGYGYKTGYDKB
VMHRCAMRCRCRCWC		 ChIP-seq
Mathelier et al.(2014)
MA0538.1 		0.759 0.657
Hr96
M03940_2.00 		Drosophila melanogaster
YVRGTRCANVTGYACYBR
YVRGTRCABNTGYACYBR		 SELEX
Nitta et al.(2015)
Hr96_1 		0.751 0.586
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F33D4.1a Nuclear receptor 24 93
F33D4.1b Nuclear receptor 24 93

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

82 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action