nhr-12 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003611 T306136_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head ganglion and tail ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); hepatocellular carcinoma; lipid metabolism disorder; and type 2 diabetes mellitus. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha) and PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-86
M02415_2.00 		Caenorhabditis elegans
KTGTAGTC
GACTACAM		 PBM
Weirauch et al.(2014)
pTH8598 		0.895 0.686
nhr-70
M00695_2.00 		Caenorhabditis elegans
NYTGTAGYYD
HRRCTACARN		 PBM
Narasimhan et al.(2015)
pTH9174 		0.802 0.657
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
R04B5.4a Nuclear receptor 45 114
R04B5.4b Nuclear receptor 45 114
R04B5.4c Nuclear receptor 45 114

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

55 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action