CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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nhr-35
(
Caenorhabditis elegans
)
Nuclear receptor
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00105 (zf-C4)
IPR001628
WBGene00003628
T306153_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in anatomical structure development; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
nhr-49
M02413_2.00
Caenorhabditis elegans
NNNNWNHAN
NTDNWNNNN
PBM
Weirauch et al.(2014)
pTH5891
0.931
0.571
nhr-1
M00686_2.00
Caenorhabditis elegans
ARTGATCA
TGATCAYT
PBM
Narasimhan et al.(2015)
pTH9322
0.882
0.471
Hnf4
M03935_2.00
Drosophila melanogaster
RGGKCAAAGGTCA
TGACCTTTGMCCY
SELEX
Nitta et al.(2015)
Hnf4_1
0.746
0.571
Hnf4
M03936_2.00
Drosophila melanogaster
RGGKCAAAGTYCA
TGRACTTTGMCCY
SELEX
Nitta et al.(2015)
Hnf4_2
0.746
0.571
Hnf4
M03937_2.00
Drosophila melanogaster
RGTVCAAAGKTCR
YGAMCTTTGBACY
SELEX
Nitta et al.(2015)
Hnf4_3
0.746
0.571
Hnf4
M03938_2.00
Drosophila melanogaster
RTGRACTTTGGACY
RGTCCAAAGTYCAY
SELEX
Nitta et al.(2015)
Hnf4_4
0.746
0.571
Hnf4
M06428_2.00
Drosophila melanogaster
DKNKWSSNGGGGTCA
TGACCCCNSSWMNMH
B1H
Zhu et al.(2011)
Hnf4_SANGER_10_FBgn0004914
0.746
0.571
Hnf4
M06429_2.00
Drosophila melanogaster
GGGGTCAH
DTGACCCC
B1H
Zhu et al.(2011)
Hnf4_SANGER_5_FBgn0004914
0.746
0.571
For this family, TFs with SR scores >
0.745
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
C07A12.3a
Nuclear receptor
75
144
SICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFESKCEIDKHNRAVCRYCRFMKCISSGMRD
C07A12.3b
Nuclear receptor
19
88
SICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFESKCEIDKHNRAVCRYCRFMKCISSGMRD
Links
Other
Nuclear receptor
family TFs
Other
Caenorhabditis elegans
TFs
246 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy